Familial Sweet's syndrome in 2 brothers, both seen in the first 2 weeks of life

Parsapour, Kourosh; Reep, Michael D.; Gohar, Kathy; Shah, Veena; Church, Annamaria; Shwayder, Tor

doi:10.1067/mjd.2003.328

Cited by 54 publications

(34 citation statements)

References 49 publications

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“…Sweet's syndrome has also been reported in children [4]. The youngest reported patients with Sweet's syndrome were two brothers, 10 and 15 days of age [5]. Our case of a 5-day-old would make her the youngest patient to be reported.…”

Section: Discussionmentioning

confidence: 59%

Nonbullous neutrophilic dermatosis: Sweet’s syndrome, neonatal lupus erythematosus, or both?

et al. 2009

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We describe a 5-day-old infant who fulfilled the diagnostic criteria for Sweet's syndrome, and the concurrent histologic and autoantibody features supporting the diagnosis of neonatal lupus. To our knowledge, this is the youngest case of Sweet's syndrome reported in the literature. Importantly, our findings further support the hypothesis that lupus erythematosus should be considered in the differential diagnosis of a nonbullous neutrophilic dermatosis, as it may represent the initial manifestation of the disease.

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Section: Discussionmentioning

confidence: 59%

Nonbullous neutrophilic dermatosis: Sweet’s syndrome, neonatal lupus erythematosus, or both?

et al. 2009

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“…6 Finally, 5 children had presumed genetic causes, 2 of whom were brothers with limited reported extracutaneous symptoms, although 1 of these children died at age 4 years from pulmonary hypertension. 27 Three other possible genetic cases came from an initial report of 4 children with what was presented as a new, probably monogenic condition of chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome 28 , which is caused by mutations in the PSMB8 gene. 29 The sibling of one of these children, who had a similar disease, was not included, as she was not reported as presenting in the first 6 months; however, importantly, she died at age 14 and therefore this association must be considered as carrying a potentially poorer prognosis.…”

Section: Results Of the Literature Reviewmentioning

confidence: 98%

Neonatal Sweet Syndrome: A Potential Marker of Serious Systemic Illness

Gray

Bock²,

Ziegler

et al. 2012

Pediatrics

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Sweet syndrome is an inflammatory disease characterized by fever and painful erythematous plaques with a dermal neutrophilic infiltrate. It is most common in adults, where it is often parainflammatory or paraneoplastic, but is rare in children. We describe 3 cases of neonatal Sweet syndrome, including 1 patient who had myelodysplastic syndrome and immunodeficiency, the first report of a premalignancy underlying infantile Sweet syndrome. We reviewed the literature on patients presenting with neutrophilic dermatosis in the first 6 months of life. Of 20 cases, 6 had a probable viral etiology, 4 primary immunodeficiencies, 3 neonatal lupus syndrome, 1 gastrointestinal involvement, 1 HIV, and 5 probable genetic cases. Three of these had chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature syndrome, caused by mutations in the PSMB8 gene. Most children who presented within the first 6 weeks of life had either a serious underlying condition, such as primary immunodeficiency, or a genetic Sweet syndrome, with 2 fatalities among this latter group. The outcome of postinfective cases was good. Extracutaneous involvement was unusual, whereas postinflammatory scarring and cutis laxa occurred in a minority of patients. In conclusion, Sweet syndrome in the neonatal period often heralds a serious underlying disorder and requires thorough investigation.

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“…Twentyseven (42%) patients were categorized in the group "classic/idiopathic Sweet's syndrome". Thirteen (21%) of these presented without associated diseases (detailed data not shown [3,6,19,20,24,25,32,34,51,53,59]) and 14 patients (22%) were reported with transient diseases, mostly respiratory tract infections or otitis media [12,13,15,26,27,29,36,39,41,44,47,55]. These patients were not included in the detailed analysis and are not shown in Tables 2 and 3.…”

Section: Resultsmentioning

confidence: 69%

“…The most recent review from 2003 reports fewer than 50 pediatric cases, 27 of them suffering from associated diseases [53].…”

Section: Introductionmentioning

confidence: 99%

Acute febrile neutrophilic dermatosis (Sweet’s syndrome) in childhood and adolescence: two new patients and review of the literature on associated diseases

2008

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Familial Sweet's syndrome in 2 brothers, both seen in the first 2 weeks of life

Cited by 54 publications

References 49 publications

Nonbullous neutrophilic dermatosis: Sweet’s syndrome, neonatal lupus erythematosus, or both?

Nonbullous neutrophilic dermatosis: Sweet’s syndrome, neonatal lupus erythematosus, or both?

Neonatal Sweet Syndrome: A Potential Marker of Serious Systemic Illness

Acute febrile neutrophilic dermatosis (Sweet’s syndrome) in childhood and adolescence: two new patients and review of the literature on associated diseases

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