Familiäre Tumorsyndrome

Osborn, Anne G.; Hedlund, Gary L.; Kliesch, Stefan

doi:10.1016/b978-3-437-21041-9.00039-x

Cited by 35 publications

(118 citation statements)

References 28 publications

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“…Radiologically, the differential diagnoses for CPP of the fourth ventricle in adults include hemangioblastoma, solitary fibrous tumor/hemangiopericytoma (SFT/HPC), and metastatic tumor. In hemangioblastoma, variably sized cysts are present in 50% to 60% of cases whereas approximately 40% of them are solid tumors [15] . Typically, the solid part shows intense enhancement.…”

Section: Discussionmentioning

confidence: 99%

Posterior fossa choroid plexus papilloma with focal ependymal differentiation in an adult patient: A case report and literature review

Matsushita

Shimono

Goto

et al. 2019

Radiology Case Reports

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Choroid plexus papillomas (CPPs) are rare neoplasms classified as World Health Organization grade I tumors. CPPs containing other tissues have occasionally been documented in the literature. However, few of these previous reports have provided clinical and radiological information. We herein report a case of a posterior fossa CPP with focal ependymal differentiation in a 42-year-old woman who presented with a 6-month history of progressive headache. Preoperative radiological images showed a hypervascular tumor protruding into the left foramen of Luschka with perilesional edema. Gross total resection of the tumor was performed. Histopathological examination revealed that the tumor was composed of papillary structures. Immunohistochemical staining of glial fibrillary acidic protein was focally positive around the capillaries, which was suggestive of “perivascular pseudorosette” formation. Our case showed similar imaging appearances as those of CPP; thus, it seems difficult to distinguish CPP with versus without ependymal differentiation by clinical and radiological features alone. The clinical significance and pathogenesis of ependymal differentiation in CPP remain unclear, and further case reports are required.

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Section: Discussionmentioning

confidence: 99%

Posterior fossa choroid plexus papilloma with focal ependymal differentiation in an adult patient: A case report and literature review

Matsushita

Shimono

Goto

et al. 2019

Radiology Case Reports

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“…Stroke lesions were diagnosed with the usual parameters for a chronic ischemic lesion seen as a cavitated cystic encephalomalacia in the area of the old ischemia. As NCC is a prevalent infectious disease on our medium, we decided to include the brain MRI studies displaying the nodular calcified state seen as hypointensities in T1-and T2-weighted image 20 .…”

Section: Methodsmentioning

confidence: 99%

A relationship between drug-resistant epilepsy and structural abnormalities in neuroimaging

Flores-Sobrecueva¹,

Paláu-Hernández²,

Cruz-Rosales³

et al. 2020

RMN

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Background and objectives:The purpose of the study was to seek a relationship between drug-resistant epilepsy and structural alterations in neuroimaging to strengthen the link between the clinical and surgical management. A second objective was to determine an association between drug-resistant epilepsy and subject gender, the age of first seizure, and the type of seizure. Materials and methods: Over 632 medical records were scrutinized in search of those satisfying the inclusion criteria to end up with a sample of 108 subjects. Neuroimaging specialists reviewed each of the magnetic resonance imaging (MRI) studies looking for abnormalities to make the structural diagnosis and define it. Results: Of the 108 patients included in the study, 51 patients (Group A) were refractory to medical treatment and 57 patients (Group B) showed an improvement with medical treatment. We quantified the frequency of structural lesions confirmed by neuroimaging in both groups. The results showed a statistically significant difference of 84.31% of patients in Group A with a confirmed structural lesion in an MRI study versus 52.63% of patients in Group B (p = 0.004 [odds ratio = 4.85,). Conclusion: Our results support the association between structural lesions diagnosed with MRI and drug-resistant epilepsy. Thus, this finding gives a chance of an opportune and precise approach for the surgical treatment of these patients.

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“…Nevertheless, there is a group of young adults in whom both types of tumours may occur. Haemangioblastomas account for 1-2.5% of intracranial tumours and 7-12% of posterior fossa neoplasms in adult patients [3,4]. Pilocytic astrocytomas are the most common paediatric central nervous system (CNS) gliomas and one of the most common paediatric cerebellar tumours representing 60% of all astrocytomas in children [2].…”

Section: Introductionmentioning

confidence: 99%

“…Morphologically, both HABLs and PAs may show heterogeneous appearance; mainly cystic but also solidcystic or solid lesions are observed [3,4].…”

Section: Introductionmentioning

confidence: 99%

The role of diffusion and perfusion magnetic resonance imaging in differentiation of haemangioblastomas and pilocytic astrocytomas

et al. 2018

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PurposeHaemangioblastomas (HABLs) and pilocytic astrocytomas (PAs) are brain tumours presenting similar appearance and location in conventional magnetic resonance (MR) imaging. The purpose of our study was to determine whether a detailed analysis of diffusion (DWI) and perfusion (PWI) characteristics can be useful in preoperative differentiation of these tumours.Material and methodsThe study group consisted of biopsy proven six HABLs and six PAs, which underwent preoperative standard MR examinations including PWI and DWI. In PWI relative cerebral blood volume (rCBV) and the shape of perfusion curves (parameters of peak height – rPH and percentage of signal recovery – rPSR) were analysed. All perfusion parameters were measured for the entire tumour core (mean rCBV, mean rPH, mean rPSR) and in regions with maximal values (max rCBV, max rPH, max rPSR). In DWI parameters of apparent diffusion coefficient (ADC) from the entire tumour core (mean ADC) and in regions with minimal values (min ADC) were evaluated.ResultsCompared to PAs, HABLs presented significantly higher rCBV and rPH values and lower mean rPSR value. PAs showed significantly lower rCBV and rPH values and higher mean rPSR value. Mean rCBV showed no overlap in the values between HABLs and PAs, and thus it provided the highest accuracy in differentiating between them. Max rPSR, mean ADC, and min ADC did not show any significant differences.ConclusionsHigh rCBV values and deep perfusion curves with only partial return to the baseline are characteristic features of HABLs differentiating them from PAs, which show lower rCBV values and perfusion curves overshooting the baseline. Diffusion parameters are not useful in differentiation of these tumours.

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Familiäre Tumorsyndrome

Cited by 35 publications

References 28 publications

Posterior fossa choroid plexus papilloma with focal ependymal differentiation in an adult patient: A case report and literature review

Posterior fossa choroid plexus papilloma with focal ependymal differentiation in an adult patient: A case report and literature review

A relationship between drug-resistant epilepsy and structural abnormalities in neuroimaging

The role of diffusion and perfusion magnetic resonance imaging in differentiation of haemangioblastomas and pilocytic astrocytomas

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