Family aggregation of mental disorders in the nationwide Danish three generation study

Steinhausen, Hans-Christoph; Foldager, Leslie; Perto, Gurli; Munk‐Jørgensen, Povl

doi:10.1007/s00406-008-0865-0

Cited by 39 publications

(42 citation statements)

References 29 publications

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“…A large scale population study of familial risk for anxiety concluded that the children of parents with anxiety disorders were significantly more likely to experience anxiety disorders, than children of parents without anxiety disorders, and this risk was elevated when both parents suffered from anxiety (Li et al 2008). These results are supported by another large scale investigation of data from the Danish population registry (Steinhausen et al 2009). …”

Section: Introductionsupporting

confidence: 74%

Cross-generational influences on childhood anxiety disorders: pathways and mechanisms

Lebowitz¹,

Leckman²,

Silverman³

et al. 2016

J Neural Transm

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Anxiety disorders are common across the lifespan, cause severe distress and impairment, and usually have their onset in childhood. Substantial clinical and epidemiological research has demonstrated the existence of links between anxiety and its disorders in children and parents. Research on the pathways and mechanisms underlying these links has pointed to both behavioral and biological systems. This review synthesizes and summarizes several major aspects of this research. Behavioral systems include vicarious learning, social referencing, and modeling of parental anxiety; overly protective or critical parenting styles; and aspects of parental responses to child anxiety including family accommodation of the child’s symptoms. Biological systems include aspects of the prenatal environment affected by maternal anxiety, development and functioning of the oxytocinergic system, and genetic and epigenetic transmission. Implications for the prevention and treatment of child anxiety disorders are discussed, including the potential to enhance child anxiety treatment outcomes through biologically informed parent-based interventions.

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Section: Introductionsupporting

confidence: 74%

Cross-generational influences on childhood anxiety disorders: pathways and mechanisms

Lebowitz¹,

Leckman²,

Silverman³

et al. 2016

J Neural Transm

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“…Family members were identified through the DCR and DPCCR as previously described [31]. Lifetime data were obtained from the first registration of any mental disorder and the maximum period of observation for the diagnostic ascertainment of relatives via the DPCRR was 40 years.…”

Section: Methodsmentioning

confidence: 99%

Family aggregation and risk factors in substance use disorders over three generations in a nation-wide study

2017

Self Cite

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ObjectiveThis nation-wide register-based study investigated how often substance use disorders (SUD) and co-morbid disorders occurred in affected families compared to control families.MethodA total of N = 2504 child and adolescent psychiatric participants who were born between 1969 and 1986 and were registered in the Danish Psychiatric Central Research Register (DPCRR) had a mental disorder before the age of 18 and developed SUD at some point during their life-time. In addition, N = 7472 controls without any psychiatric diagnosis before age 18 and matched for age, sex, and residential region were included. Psychiatric diagnoses of the first-degree relatives were also obtained. A family load component was assessed.ResultsSUD occurred significantly more often in case families than in control families. SUD risk factors included SUD, depression, anxiety disorders, personality disorders, or conduct disorders in the family. Furthermore, male sex, more recent year of birth, and living in the capital city of Copenhagen were also significantly associated with having SUD. The family load explained 30% of the SUD manifestation in the case-probands. The findings in the total SUD group were mostly replicated in the two major subgroups of pure alcohol or multiple substance use disorders.DiscussionThese findings based on a very large and representative dataset provide additional evidence for the strong family aggregation and further risk factors in SUD. The pattern of risk factors is largely the same for the total group of SUD and the major subgroups of pure alcohol and multiple substance use disorders.

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“…For example, a data linkage study of over 20,000 people in the Danish population with a psychiatric record indicated an individual with an anxiety disorder was 6.8 times more likely to have a first-degree relative with another disorder (Steinhausen et al 2009). Similar probabilities were demonstrated regardless of whether the relative was a parent, sibling, or child of the proband.…”

Section: Family Transmissionmentioning

confidence: 98%

Family Factors in the Development and Management of Anxiety Disorders

Rapee

2011

Clin Child Fam Psychol Rev

151

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Family variables are thought to play a key role in a wide variety of psychopathology according to many theories. Yet, specific models of the development of anxiety disorders place little emphasis on general family factors despite clear evidence that anxiety runs in families. The current review examines evidence for the involvement of a number of family-related variables in the development of anxiety disorders as well as the importance of families in their management. Evidence across most areas is shown to be weak and inconsistent, with the one exception being an extensive literature on the role of parenting in the development of anxiety. There is also currently little evidence that family factors have a strong role to play in the treatment of anxiety, aside from research demonstrating the value of parents and partners as non-critical supports in therapy. The promises and hints in the literature, combined with the currently inconsistent methods, suggest that considerably more research is needed to determine whether specific family factors may yet be shown to play a key role in the development and management of anxiety disorders.

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Family aggregation of mental disorders in the nationwide Danish three generation study

Cited by 39 publications

References 29 publications

Cross-generational influences on childhood anxiety disorders: pathways and mechanisms

Cross-generational influences on childhood anxiety disorders: pathways and mechanisms

Family aggregation and risk factors in substance use disorders over three generations in a nation-wide study

Family Factors in the Development and Management of Anxiety Disorders

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