Family‐based association of HLA‐DRB1 and DQB1 alleles and haplotypes in a group of Iranian Type 1 diabetes children
Ata Shirizadeh,
Zahra Razavi,
Vahid Saeedi
et al.
Abstract:This family‐based study was conducted in a group of Iranians with Type 1 diabetes (T1D) to investigate the transmission from parents of risk and non‐risk HLA alleles and haplotypes, and to estimate the genetic risk score for this disease within this population. A total of 240 T1D subjects including 111 parent–child trios (111 children with T1D, 133 siblings, and 222 parents) and 330 ethnically matched healthy individuals were recruited. High‐resolution HLA typing for DRB1/DQB1 loci was performed for all study … Show more
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