Family cluster of asymptomatic infections with COVID-19: a case series of 4 patients

Deng, Lingbo; Ji, Lele; Meng, Zuowei; Gan, Yong; Cheng, Guangming

doi:10.21037/qims.2020.04.15

Cited by 3 publications

(4 citation statements)

References 3 publications

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“…Forty‐six articles met the inclusion and exclusion criteria and were analyzed for the systemic review (Figure 1). 13‐58 The study characteristics and results of the systematic review are demonstrated in Table 1. All the included articles were published from 1 February 2020 to 20 June 2020.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty studies were conducted in China, [13][14][15][16][17][18]22,23,[25][26][27][28][29]35,37,[49][50][51]56,57 thirteen in the United States, 32,33,[39][40][41][42]44,[46][47][48][53][54][55] two each in Italy 21,58 and Iran, 20,24 and one each in Korea, 19 Vietnam, 30 Malaysia, 31 Spain, 34 Lebanon, 36 Belgium, 38 the UK, 43 Turkey, 45 and France. 52 We identified a total of 114 pediatric patients with COVID-19.…”

Section: Resultsmentioning

confidence: 99%

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Clinical characteristics of COVID‐19 in children: A systematic review

Yasuhara

Kuno

Takagi

et al. 2020

Pediatric Pulmonology

251

250

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Background Limited pediatric cases with coronavirus disease 2019 (COVID‐19) have been reported and the clinical profiles regarding COVID‐19 in children remain obscure. Our aim was to investigate the clinical characteristics of COVID‐19 in children. Methods PUBMED and EMBASE were searched through 20 June 2020, for case reports and case series reporting pediatric COVID‐19 cases. Epidemiological, clinical, laboratory, and radiological data were collected and analyzed to compare by age. Results Our search identified 46 eligible case reports and case series. A total of 114 pediatric cases with COVID‐19 were included. The main clinical features were mild symptoms including fever (64%), cough (35%), and rhinorrhea (16%), or no symptoms (15%). Ground‐like opacities were common radiological findings (54%). The main laboratory findings were lymphopenia (33%) and elevated D‐dimer (52%) and C‐reactive protein (40%) levels. We identified 17 patients (15%) with multisystem inflammatory syndrome in children (MIS‐C) manifesting with symptoms overlapping with, but distinct from, Kawasaki disease, including gastrointestinal symptoms, left ventricular systolic dysfunction, shock, and marked elevated inflammatory biomarkers. Twelve percent of the patients including 65% of the MIS‐C cases required intensive care because of hypotension. No deaths were reported. Conclusion This systematic review found that children with COVID‐19 are generally less severe or asymptomatic. However, infants might be seriously ill and older children might develop MIS‐C with severe illness. Early detection of children with mild symptoms or an asymptomatic state and early diagnosis of MIS‐C are mandatory for the management of COVID‐19 and the prevention of transmission and a severe inflammatory state.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Clinical characteristics of COVID‐19 in children: A systematic review

Yasuhara

Kuno

Takagi

et al. 2020

Pediatric Pulmonology

251

250

View full text Add to dashboard Cite

show abstract

“…This was the first study that confirmed human-to-human transmission of SARS-CoV-2. Since then, many family clusters of COVID-19 have been reported worldwide ( Qian et al, 2020 , Zhang et al, 2020a , Chan et al, 2020 , Xu et al, 2020 , Wolf et al, 2020 , Chiu et al, 2020 , To and Fok, 2020 , Qiu et al, 2020a , Liu et al, 2020b , Wei et al, 2020a , Zhang et al, 2020b , Ye et al, 2020 , Tang et al, 2020 , Ji et al, 2020 , Phan et al, 2020 , Deng et al, 2020 , Du et al, 2020 , Huang et al, 2020a , Jiang et al, 2020a , Liu et al, 2020c , Xiong et al, 2020 , Gao et al, 2020a , Chen et al, 2020a , Yu et al, 2020 , Yang et al, 2020 , Tong et al, 2020 , Qiu et al, 2020b , Pan et al, 2020 , Luo et al, 2020 , Lu et al, 2020a , Li et al, 2020a , Li et al, 2020b , Huang et al, 2020b , Huang et al, 2020c , Gao et al, 2020b , Chen et al, 2020b , Chen et al, 2020c , Bai et al, 2020a , Liu et al, 2020d , Bai et al, 2020b , Jiang et al, 2020b , Ghinai et al, 2020 , Zhang et al, 2020c , Lu et al, 2020b , Cao et al, 2020 ). Family clusters usually have a higher risk of infection due to their close and frequent contact ( Bi et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Cluster infections play important roles in the rapid evolution of COVID-19 transmission: A systematic review

Liu

Gong

Xiao

et al. 2020

International Journal of Infectious Diseases

101

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“…The 2019 novel coronavirus disease (COVID-19) has become a global health crisis since its initial outbreak. Besides the typical manifestations of fever, respiratory symptoms, myalgia, lymphopaenia and radiological evidence of pneumonia, asymptomatic infections have also been reported [1]. With presumed asymptomatic transmission of COVID-19 during the incubation period [2], prevention of widespread transmission is challenging.…”

Section: Introductionmentioning

confidence: 99%

Retrospective Diagnosis of COVID-19 in an Asymptomatic Patient Undergoing Emergency Surgery

Chong¹,

Moo²

2020

OJAnes

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Background: With reports of higher mortality and complications occurring in patients with perioperative 2019 novel coronarvirus disease (COVID-19), most elective surgeries have been postponed. However, evidence regarding emergency surgeries in patients with COVID-19 remains scarce. We report the case of a patient with asymptomatic perioperative COVID-19, presenting with an acute abdomen requiring surgery. Case: A 25-year-old male, with a prior nasopharyngeal swab that was negative for SARS-CoV-2, presented with classical signs and symptoms of acute appendicitis. Clinical examination and investigations were not suggestive of COVID-19 infection. He underwent laparoscopic appendicectomy with infection control precautions. Postoperatively, he was found to be positive for SARS-CoV-2 but remained asymptomatic and had an uneventful recovery. Conclusion: In asymptomatic individuals with higher risks, negative test results should be viewed cautiously. The benefits of urgent surgical interventions must be weighed against the risks of complications due to perioperative COVID-19 in these patients.

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Family cluster of asymptomatic infections with COVID-19: a case series of 4 patients

Cited by 3 publications

References 3 publications

Clinical characteristics of COVID‐19 in children: A systematic review

Clinical characteristics of COVID‐19 in children: A systematic review

Cluster infections play important roles in the rapid evolution of COVID-19 transmission: A systematic review

Retrospective Diagnosis of COVID-19 in an Asymptomatic Patient Undergoing Emergency Surgery

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