Objective: This is a follow-up study designed to determine the predictive value of psychopathology and family-related variables in schizophrenia patients and their relatives. Methods: Forty-four schizophrenia patients and one of their relatives living with them were assessed one month and six-to-eight months after release from hospital. Sociodemographic characteristics were questioned and quality of life of patients was assessed using the World Health Organisation Quality of Life Scale Results: Depressive symptoms must be taken into consideration in order to improve the quality of life in schizophrenia patients. The importance of family environment should be emphasized, recommending that family rules should be flexible, and tolerance towards the patient should be increased for stable patients to improve their quality of lives. Conclusion: No changes were observed in the quality of life levels in schizophrenia patients and their relatives in time. In the same period, a decrease was observed in positive and negative symptoms, depressive symptoms, disorder severity and conflict in family environment, while insight and functionality were improved. Statistically, the most robust predictor of patients' quality of life was found to be the severity of depressive symptoms. Additionally, greater tolerance and less conflict in the family environment and family members' support to each other have been found to be related to various domains of the quality of life. The relatives' quality of life did not show any significant change in the follow-up controls as well. The most important predictor of their quality of life was less conflict in the family environment. (Archives of Neuropsychiatry 2010; 47: 292-6) Key words: Schizophrenia, quality of life, family environment, expressed emotion ÖZET Amaç: Bu izlem çal›flmas› flizofreni hastalar›nda öznel yaflam kalitesinin hastal›k ve aileye iliflkin etmenlerle iliflkisini saptamay› amaçlamaktad›r. Yöntemler: K›rkdört flizofreni hastas› ve birlikte yaflad›klar› birer akrabalar› taburculuktan bir ve alt›-sekiz ay sonra de¤erlendirilmifltir. Sosyodemografik özellikler sorgulanm›fl, hastalar›n yaflam kalitesi için Dünya Sa¤l›k Örgütü Yaflam Kalitesi Ölçe¤i K›sa Formu Türkçe Versiyonu (WHOQOL-BREF-TR); aileye iliflkin de¤iflkenler için Aile Ortam› Ölçe¤i (AOÖ) ve D›flavuran Duygudurum Düzeyi Ölçe¤i; hastal›¤a iliflkin de¤iflkenler için Calgary fiizofrenide Depresyon Ölçe¤i, fiizofrenide Negatif ve Pozitif Belirtileri De¤erlendirme Ölçekleri, Anormal ‹stemsiz Hareketler Ölçe¤i, ‹fllevselli¤in Genel De¤erlendirilmesi Ölçe¤i ve Klinik Global ‹zlem Ölçe¤i; içgörü için Markova-Berrios ‹çgörü Ölçe¤i kullan›lm›flt›r.Hasta akrabalar› da AOÖ, D›flavuran Duygudurum ve WHOQOL-BREF-TR ölçekleriyle de¤erlendirilmifltir. Bulgular: fiizofreni hastalar›n›n yaflam kalitesini art›rmak için depresif belirtilerin varl›¤› dikkate al›nmal›d›r. Aile ortam›n›n hastan›n yaflam kalitesi aç›s›ndan önemi ailelere aktar›lmal›, aile içi kurallar›n hastal›¤›n stabil dönemlerinde esnetilebilmesi ve hastaya gösterilen ho...