Family histories in Asian and European non‐insulin‐dependent diabetic patients

Abstract

Family histories of 135 Asian Indian and 146 European NIDD patients attending clinics in Ealing and Hammersmith Hospitals were obtained, using a detailed questionnaire. Forty‐five per‐cent of Asian and 36% of European patients had a first‐degree relative with diabetes. Twenty‐eight per‐cent of Asians and 20% of Europeans had one diabetic parent. In 10% of Asians and 1% of Europeans, both parents were diabetic (p<0.01). Autosomal‐dominant inheritance was seen in 14% of Asians and 4% of Europeans (p<0.01). The higher frequency of diabetes in parents, and the higher frequency of dominantly‐inherited diabetes among Asians compared to European NIDD patients, suggest that genetic mechanisms operating in NIDD are different in different ethnic groups.

Lean People with Dysglycemia Have a Worse Metabolic Profile Than Centrally Obese People Without Dysglycemia

“…34,35 However, in the present study, in the group with dysglycemia, family history of diabetes was not different from that of the group with high WC/ no dysglycemia. It has been shown that normal-weight individuals with dysglycemia have impaired first-phase insulin secretion compared with those with normoglycemia.…”

High prevalence of diabetes and impaired glucose tolerance in India: National Urban Diabetes Survey

“…Asian Indians have an ethnic susceptibility to Type II diabetes [16,17] and a high familial aggregation of the disease [18,19]. In ethnic groups such as the Naruans with high prevalence of Type II diabetes, a plateau seems to have been reached [20].…”

Lack of excess maternal transmission of type 2 diabetes in a Korean population

“…families [1][2][3][4][5][6][7] and monozygous twin studies [8,9]. It is now known that maturity-onset diabetes of the young (MODY) is an autosomal-dominant monogenic disease caused by a number of MODY genes [10].…”