2006
DOI: 10.1111/j.1538-7836.2006.02139.x
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Family history and inherited thrombophilia

Abstract: See also Lindqvist PG, Carlson J. Family secrets to be disclosed. This issue, pp 2180-1.Summary. Background: It is a common belief that patients with venous thrombosis and a positive family history for venous thromboembolism (VTE) have an increased likelihood of having an inherited thrombophilic defect. Methods: We analyzed the relation between family history, qualified with three different methods, and thrombophilic status in 314 patients with proven VTE. A positive family history (one or more first-degree re… Show more

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Cited by 64 publications
(56 citation statements)
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“…Moreover, among Blacks, VTE has been associated with increased levels of fibrinogen, [29] factor VIII [47], and plasma fibrin D-dimer [48]. Although the lower prevalence of a family history of VTE among Blacks when compared with Whites might argue against a heritable component, this observation could also be explained by the frequent incomplete penetrance of inherited thrombophilia [14,[49][50][51].…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, among Blacks, VTE has been associated with increased levels of fibrinogen, [29] factor VIII [47], and plasma fibrin D-dimer [48]. Although the lower prevalence of a family history of VTE among Blacks when compared with Whites might argue against a heritable component, this observation could also be explained by the frequent incomplete penetrance of inherited thrombophilia [14,[49][50][51].…”
Section: Discussionmentioning
confidence: 99%
“…1 A positive family history is an independent risk factor for VTE that may reflect the presence of a hereditary thrombophilic disorder. However, the predictive value of a positive family history for detection of known heritable causes of VTE is low, 2,3 suggesting that there are as-yet undiscovered genetic or environmental risk factors that account for the familial clustering of this disorder.…”
mentioning
confidence: 99%
“…Some suggest testing only in those with a family history of VTE. However, information on family history is often unreliable, and a positive family history of VTE does not predict discovery of thrombophilia (8 ). In our practice, we recommend thrombophilia testing in any patient with unprovoked VTE who desires testing.…”
Section: Patient Selectionmentioning
confidence: 98%