Family history and renin-angiotensin system gene polymorphisms in Chinese patients with type 2 diabetes mellitus

Huang, Yan-Mei; Qiao, Yong-Chao; Ling, Wei; Geng, Lijun; Xiao, Jian-long; Zhang, Xiaoxi; Zhao, Hai-Lu

doi:10.1097/md.0000000000009148

Cited by 4 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Up to now, a number of genetic factors have been reported to be associated with the onset of T2DM. Importantly, the crucial role of family history in the onset of T2DM has been widely reported which might be powerful than genetic factors, with the most likely explanation of that a family history reveals elements of lifestyle [25]. Therefore, in the present study, the enrolled T2DM patients had no family history.…”

Section: Discussionmentioning

confidence: 91%

Association ofIL-16gene polymorphisms with the risk of developing type 2 diabetes mellitus in the Chinese Han population

et al. 2019

View full text Add to dashboard Cite

Objective: The aim of the present study was to explore the genetic association of single nucleotide polymorphisms (SNPs) in interleukin-16 (IL-16) gene with type 2 diabetes mellitus (T2DM) susceptibility in a Chinese Han population. Methods: In total, 133 T2DM patients and 127 healthy controls matched by age and gender were recruited in the case–control study. IL-16 gene rs4778889 and rs11556218 polymorphisms were genotyped in the two groups via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Differences in genotype and allele distributions between groups were compared by the χ2 test. All the comparisons were adjusted for age, gender, and body mass index (BMI) by logistic regression. The odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the association strength between IL-16 gene polymorphism and T2DM risk. Results: The TG genotype and G allele frequencies of rs11556218 increased remarkably in the case group than that in controls (45.86 vs 33.86%; 29.70 vs 20.87%), and the differences reached a significant level (P<0.05). After adjusting for age, gender, and BMI, the differences still reached a significant level (P<0.05). Rs11556218 TG genotype carriers had a 1.769-fold increased risk of developing T2DM (OR = 1.769, 95% CI = 1.045–2.994), and G allele was also associated with an increased risk of T2DM (OR = 1.639, 95% CI = 1.087–2.471). IL-16 rs4778889 polymorphism showed no significant association with T2DM risk. Conclusion: IL-16 gene rs11556218 polymorphism was significantly associated with T2DM susceptibility in the Chinese Han population, while rs4778889 was not.

show abstract

Section: Discussionmentioning

confidence: 91%

Association ofIL-16gene polymorphisms with the risk of developing type 2 diabetes mellitus in the Chinese Han population

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Functional abnormality of the renin-angiotensin-aldosterone system (RAAS) is a substantial cause of blood pressure elevation, especially in young people who may still have good arterial elasticity and are therefore more likely to have normal SBP and relatively high DBP 19 . The precise mechanism for the inverse association between coarse food grain intake and blood pressure is unclear.…”

Section: Discussionmentioning

confidence: 99%

Inverse Relationship Between Coarse Food Grain Intake and Blood Pressure Among Young Chinese Adults

Liu

Liao

Gan

et al. 2018

American Journal of Hypertension

View full text Add to dashboard Cite

BACKGROUND: Coarse food grains are rich in dietary fiber and contain a wide range of nutrients with potential health benefits, such as blood pressure control.Coarse food grains are very popular in China, where hypertension is a major challenge. We evaluated the associations between coarse food grain consumption and blood pressure among young Chinese adults. METHODS:A total of 104 men and women aged 18 to 35 years, who participated in a pilot study of the Carbohydrate Alternatives and Metabolic Phenotypes study, were included in the present analysis. Food frequency questionnaires were used to collect dietary intake data. Blood pressure was measured using a digital monitor. A multivariate general linear model was used to evaluate the putative associations. RESULTS: Overall, 12.5 % of our participants have regular habits of coarse food grain intake (at least 4 days/Wk). Age was positively associated with both systolic blood pressure (SBP) and diastolic blood pressure (DBP) (all P for trend < 0.05).With multivariable adjustment, including for body mass index and physical activity

show abstract

“…Genetic analysis involved the amplification of genomic DNA by polymerase chain reaction (PCR) (Bio-Rad, Hercules, CA, USA). Primer pairs (SNP Biotechnology R&D Ltd., Ankara, Turkey) were selected to amplify the DNA fragment containing the AGT gene (T704C, rs699) polymorphism, as was published previously [13]. The sequence of the forward primer is 5 ′ -CCG TTT GTG CAG GGC CTG GCT CTC T-3 ′ , while the reverse primer is 5 ′ -CAG GGT GCT GTC CAC ACT GGA CCC C-3 ′ .…”

Section: Genotypingmentioning

confidence: 99%

The Association of M235T Genetic Polymorphism in Angiotensinogen Gene and Other Non-Genetic Factors with Essential Hypertension among Jordanian Patients

Alhawari,

Jarrar,

Zihlif

et al. 2024

JPM

View full text Add to dashboard Cite

Background: Hypertension, characterized by elevated pressure, poses a significant health risk. Recent studies in Jordan highlight high hypertension rates, emphasizing the need for genetic investigations to comprehend essential hypertension determinants. The AGT gene, part of the Renin Angiotensin System, is linked to blood pressure regulation. Limited information exists on the frequency of this polymorphism among Jordanian hypertensive patients. Aims: This study explores the association between the AGT M235T polymorphism and essential hypertension in Jordan. Methods: A cross-sectional study with 435 participants (199 hypertensive, 236 non-hypertensive) was conducted at the University of Jordan Hospital. Blood pressure was measured, and genetic analysis of the AGT M235T polymorphism was completed using the PCR-RFLP technique. Chi-square and t-tests were used for comparisons using SPSS software. Results: Hypertensive patients exhibited significantly higher weight, BMI, and blood pressure. Genotyping results showed no significant difference (p > 0.05, Chi-square) in AGT M235T polymorphism distribution between control and patient groups. In addition, allele frequencies showed comparable patterns (p > 0.05, Chi-square). All genotype frequencies showed no deviation from the Hardy–Weinberg equation (p > 0.05, Chi-square). Conclusions: The AGT M235T genetic polymorphism is not more prevalent among hypertensive patients in Jordan, although the average weight and BMI among hypertensive patients is higher than the non-hypertensive participants. Obesity can be addressed as a potential risk factor for essential hypertension in Jordan. In addition, it is recommended to find out the influence of the AGT M235T genetic polymorphism on the response of antihypertensive drugs among hypertensive patients in Jordan.

show abstract

Family history and renin-angiotensin system gene polymorphisms in Chinese patients with type 2 diabetes mellitus

Abstract: Supplemental Digital Content is available in the text

Cited by 4 publications

References 30 publications

Association ofIL-16gene polymorphisms with the risk of developing type 2 diabetes mellitus in the Chinese Han population

Association ofIL-16gene polymorphisms with the risk of developing type 2 diabetes mellitus in the Chinese Han population

Inverse Relationship Between Coarse Food Grain Intake and Blood Pressure Among Young Chinese Adults

The Association of M235T Genetic Polymorphism in Angiotensinogen Gene and Other Non-Genetic Factors with Essential Hypertension among Jordanian Patients

Contact Info

Product

Resources

About