Family history as a risk factor for pelvic organ prolapse

McLennan, Mary T.; Harris, Jenine K.; Kariuki, Barbara; Meyer, Sara C.

doi:10.1007/s00192-008-0591-1

Cited by 45 publications

(29 citation statements)

References 21 publications

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“…Other human studies have suggested that alterations in genes responsible for elastic fiber homeostasis are more common in women with clinical manifestations of POP (23), and family history is a known risk factor for the development of this disease (24). It would be important to understand how genetic susceptibility plays into the elastinopathic pathways identified in murine models.…”

Section: Discussionmentioning

confidence: 99%

Fibulin-5: two for the price of one maintaining pelvic support

Northington

2011

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 99%

Fibulin-5: two for the price of one maintaining pelvic support

Northington

2011

J. Clin. Invest.

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“…Probably, the factors that play a role in the occurrence of pelvic organ prolapse in the first place are also risk factors for recurrence of prolapse after surgery. Risk factors for pelvic organ prolapse that have been described in literature are aging [4, 5], obesity [4, 6], family history of prolapse [7, 8], and collagen weakness [5]. Furthermore, there is a strong relationship between vaginal child birth and pelvic organ prolapse [4, 7, 9].…”

Section: Introductionmentioning

confidence: 99%

Avulsion of puborectalis muscle and other risk factors for cystocele recurrence: a 2-year follow-up study

et al. 2011

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Introduction and hypothesisThis study aimed to determine the relationship of recurrent cystocele with avulsion of puborectalis muscle and other risk factors.MethodsIn this prospective observational cohort study, 245 women undergoing anterior colporrhaphy were invited for a 2-year follow-up visit consisting of a questionnaire, physical examination, and translabial 3D ultrasonography. Women with and without recurrent cystocele were compared to identify recurrence risk factors.ResultsOf the 245 women, 156 agreed to the follow-up visit (63.7%). Objective recurrence rate was 80 of 156 (51.3%). Seventeen of the 156 (10.9%) reported subjective recurrence. Risk factors for anatomical recurrence were complete avulsion of puborectalis muscle (OR, 2.4; 95% CI, 1.3, 4.7), advanced preoperative stage (OR, 2.0; 95% CI, 1.0, 4.1), family history of prolapse (OR, 2.4; 95% CI, 1.2, 4.9), and sacrospinous fixation (OR, 6.5; 95% CI, 2.0, 21.2).ConclusionsRisk factors for anatomical cystocele recurrence after anterior colporrhaphy were complete avulsion of puborectalis muscle, advanced preoperative stage, family history of prolapse, and sacrospinous fixation.

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“…1 The aetiology of POP is considered to be multifactorial. Based on the recently published integrated life span model, 6 it can be assumed that the development of POP includes predisposing factors (growth and development, genetic factors, connective tissue weakness, joint mobility), [7][8][9][10][11][12] inciting factors (childbirth, pelvic surgery) [12][13][14][15][16][17][18] and intervening factors (age-related changes, obesity, constipation, heavy occupational work, vigorous physical activity). 12,[14][15][16][17][18][19][20][21][22][23][24] Unfortunately, only a minority of these risk factors can easily be prevented.…”

Section: Introductionmentioning

confidence: 99%

Pelvic floor function is independently associated with pelvic organ prolapse

Brækken

Majida

Engh

et al. 2009

BJOG

113

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Objective To investigate the risk factors for pelvic organ prolapse (POP), including physical activity, clinically measured joint mobility and pelvic floor muscle (PFM) function.Design One-to-one age-and parity-matched case-control study.Setting Akershus university hospital and one outpatient physiotherapy clinic in Norway.Population Forty-nine women with POP (POP quantification, stage ‡II) and 49 controls (stages 0 and I) were recruited from community gynaecologists and advertisements in newspapers.Methods Validated questionnaires, interview and clinical examination, including Beighton's scoring system (joint hypermobility) and vaginal pressure transducer measurements (PFM function), were used. Univariate and multivariate conditional logistic regression analyses for one-to-one matched case-control studies were used, and odds ratios with 95% CIs are reported.Main outcome measures Pelvic floor muscle function (strength, endurance and resting pressure), socioeconomic status, body mass index, heavy occupational work, physical activity, family history, obstetric factors and markers of connective tissue weakness (striae, varicose veins, bruising, diastasis recti abdominis, joint hypermobility).Results No significant differences were found between groups with regard to postmenopausal status, current smoking, current low-intensity exercise, type of birth (caesarean, forceps, vacuum), birth weight, presence of striae, diastasis recti abdominis and joint hypermobility. Body mass index (OR 5.0; 95% CI 1.1-23.0), socioeconomic status (OR 10.5; 95% CI 2.2-50.1), heavy occupational work (OR 9.6; 95% CI 1.3-70.3), anal sphincter lacerations (OR 4.5; 95% CI 1.0-20.0), PFM strength (OR 7.5; 95% CI 1.5-36.4) and endurance (OR 11.5; 95% CI 2.0-66.9) were independently related to POP.Conclusions Body mass index, socioeconomic status, heavy occupational work, anal sphincter lacerations and PFM function were independently associated with POP, whereas joint mobility and physical activity were not.Keywords Anal sphincter lacerations, body mass index, casecontrol, joint hypermobility, occupational work, pelvic floor muscle, pelvic organ prolapse, socioeconomic status, varicose veins.Please cite this paper as: Braekken I, Majida M, Ellström Engh M, Holme I, Bø K. Pelvic floor function is independently associated with pelvic organ prolapse.

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Family history as a risk factor for pelvic organ prolapse

Cited by 45 publications

References 21 publications

Fibulin-5: two for the price of one maintaining pelvic support

Fibulin-5: two for the price of one maintaining pelvic support

Avulsion of puborectalis muscle and other risk factors for cystocele recurrence: a 2-year follow-up study

Pelvic floor function is independently associated with pelvic organ prolapse

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