Family history does not predict angiographic localization or severity of coronary artery disease

Banerjee, Amitava; Lim, C.C.S.; Silver, L E; Heneghan, Carl; Welch, Sarah; Mehta, Ziyah; Banning, Adrian P.; Rothwell, Peter M.

doi:10.1016/j.atherosclerosis.2012.01.033

Cited by 8 publications

(4 citation statements)

References 40 publications

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“…No significant association is noted between family history and severity of CAD (p=0.12). Amvita banerjee et al 17 in their study concluded that sex-specific family history data do not predict angiographic localization of coronary disease in patients presenting with ACS. Smoking is found to be significantly associated with severe CAD (p<0.0001) and is very common in males in central India.…”

Section: Discussionmentioning

confidence: 96%

Clinical and Angiographic Profile of Suspected Coronary Artery Disease Patients in Central India

Yadav¹

2017

jmscr

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Section: Discussionmentioning

confidence: 96%

Clinical and Angiographic Profile of Suspected Coronary Artery Disease Patients in Central India

Yadav¹

2017

jmscr

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“…Overall, our results were somewhat consistent with the results of a study by Amitava et al, where they concluded that FH data do not predict angiographic localization of coronary disease in patients presenting with acute coronary syndrome (ACS). Maternal stroke and maternal myocardial infarction may affect ACS in women by a mechanism unrelated to atherosclerosis or coronary anatomy ( 21 ). However, FH data may still be useful in the risk prediction and prognosis of ACS.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Relationship between Family History and Occurrence, Anatomical Location, and Extent of Coronary Artery Disease among Patients Undergoing Coronary Angiography

Ashrafi,

Yazdi,

Farhadian

2023

MJIRI

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Background A positive family history (FH) of coronary artery disease (CAD) is considered an independent risk factor for developing CAD. However, the relationship between the occurrence, angiographic anatomical location of the stenosis, and extent of CAD and the risk factors in the patients and their relatives is not well defined. Evaluation of this relationship is our main goal in this study. Methods In this descriptive cross-sectional study, the FH data for CAD and premature death in first-and second-degree relatives, angiographic anatomical location of the stenosis, the extent of CAD in the patients and their relatives, as well as the relationship between other risk factors and the extent of CAD, were collected from 300 adult patients undergoing coronary angiography at Farshchian cardiovascular hospital in Hamadan (Iran) between March 2020 and 2021. SPSS 24 and the chi-square, Fisher exact, and student t tests were used to analyze data. The significance level was considered P < 0.05. Results Out of 300 patients, 185 (61.7%) were men and 115 (38.3%) were women. A total of 177 patients (59%) in maternal and 82 patients (27.3%) in paternal relatives had an FH of CAD. There was a significant relationship between the severity of coronary artery involvement and risk factors ( P < 0.001). Moreover, there was no significant relationship between the location of coronary artery involvement of the right coronary artery, left coronary artery, and left anterior descending artery and the severity of involvement of patients undergoing coronary angiography and their first- and second-degree relatives ( P = 0.480). Conclusion Our findings suggest that there was no significant relationship between the anatomical location of the stenosis and the number of vessels involved and the FH of the patients. In patients with an FH, the extent of CAD significantly increased according to their risk factors for heart disease.

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“…Reality is that, many researchers have shown discrepant results and many other researchers have concluded that many of the conventional risk enhancers are also strongly correlated with anatomical severity. while some have shown that only few of these factors are good predictors of anatomical severity (Banerjee et al, 2012;Krishnaswami et al, 1994). Different study designs and geographic and ethnic factors are responsible for this.…”

Section: Discussionmentioning

confidence: 99%

“…The association of these risk factors with presence of CAD and its harmful effects is well established. Less consistency has found among risk enhancers and CAD severity on correlation, and many studies have produced conflicting results (Banerjee et al, 2012;Koliaki et al, 2011;Larifla et al, 2014). Larifla et al conducted a study to find the association of these factors and disease severity in coronaries and found that diabetes and male gender are independent risk factors of severity of CAD (Larifla et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Modifiable Risk Factors and Coronary Artery Disease Severity: Insights From a Case-Control Analysis

JAVAID,

ALI,

RAZZAQ

et al. 2023

Biol Clin Sci Res J

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Atherosclerotic coronary disease stands as a leading cause of both mortality and morbidity globally. The well-documented risk factors for coronary artery disease (CAD) include abnormal lipid levels, obesity, smoking, high blood pressure, and diabetes. The established association between these cardiovascular risk factors and ischemic heart disease is widely recognized. However, the correlation between risk factors for ischemic heart disease and the severity of CAD on coronary angiography remains less explored, with varying findings across studies. Our research involved a total of 200 patients aged 30 to 70 years, comprising 100 cases diagnosed with severe CAD and 100 controls with insignificant CAD. Factors contributing to CAD, such as smoking, high sugar levels, high blood pressure, lipid profiles, family history of CAD, and obesity, were assessed in all patients. Statistical analysis, employing the chi-square test, was conducted, and a significant association was considered when the odds ratio value exceeded 1. The mean age in our study population was 51.01 ± 7.76 years, with 159 (79.50%) being male. Among the patients, 99 (49.50%) were obese, 90 (45.0%) were diabetic, 94 (47.0%) were hypertensive, 77 (38.5%) were smokers, 53 (26.5%) had a positive family history, and 17 (8.5%) were dyslipidemic. In evaluating the association of cardiovascular risk factors with CAD severity, smoking (odds ratio 1.73, p-value 0.04), hypertension (odds ratio 1.6, p-value 0.05), diabetes (odds ratio 1.6, p-value 0.05), and obesity (odds ratio 1.98, p-value 0.016) emerged as independent factors significantly linked to the severity of CAD. Our findings underscore the independent roles of smoking, hypertension, diabetes, and obesity as risk factors contributing to the severity of ischemic heart disease.

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Family history does not predict angiographic localization or severity of coronary artery disease

Cited by 8 publications

References 40 publications

Clinical and Angiographic Profile of Suspected Coronary Artery Disease Patients in Central India

Clinical and Angiographic Profile of Suspected Coronary Artery Disease Patients in Central India

Evaluation of the Relationship between Family History and Occurrence, Anatomical Location, and Extent of Coronary Artery Disease among Patients Undergoing Coronary Angiography

Modifiable Risk Factors and Coronary Artery Disease Severity: Insights From a Case-Control Analysis

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