Family history in early-onset inflammatory bowel disease

Bianco, Anna Monica; Zanin, Valentina; Monasta, Lorenzo; Martelossi, Stefano; Marcuzzi, Annalisa; Crovella, Sérgio

doi:10.1007/s00535-012-0654-4

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…[30][31][32] Differently from these reports, we did not find significant differences for family history between the EO and the later-onset groups. This figure can be explained by the homogeneous colonic involvement in the EO disease, while multiple locations with more variable clinical pictures were found in later-onset forms.…”

Section: Discussioncontrasting

confidence: 99%

Phenotype and Disease Course of Early-onset Pediatric Inflammatory Bowel Disease

Aloi

Lionetti

Barabino

et al. 2014

Inflammatory Bowel Diseases

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128

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BACKGROUND:\ud Early-onset (EO) pediatric inflammatory bowel diseases (IBD) seem to be more extensive than those with a later onset. To test this hypothesis, we examined the phenotype and disease course of patients with IBD diagnosis at 0 to 5 years, compared with the ranges 6 to 11 and 12 to 18 years.\ud METHODS:\ud Anatomic locations and behaviors were assessed according to Paris classification in 506 consecutive patients: 224 Crohn's disease, 245 ulcerative colitis, and 37 IBD-unclassified.\ud RESULTS:\ud Eleven percent of patients were in the range 0 to 5 years, 39% in 6 to 11 years, and 50% in 12 to 18 years. Ulcerative colitis was the most frequent diagnosis in EO-IBD and in 6- to 11-year-old group, whereas Crohn's disease was predominant in older children. A classification as IBD-unclassified was more common in the range 0 to 5 years compared with the other groups (P < 0.005). EO Crohn's disease showed a more frequent isolated colonic (P < 0.005) and upper gastrointestinal involvement than later-onset disease. Sixty-two percent of the patients in the 0 to 5 years range had pancolonic ulcerative colitis, compared with 38% of 6 to 11 years (P = 0.02) and 31% of 12-18 years (P = 0.002) range. No statistical difference for family history for IBD was found in the 3-year age groups. Therapies at the diagnosis were similar for all children. However, at latest follow-up, a significantly higher proportion of younger children were under steroids compared with older groups (P < 0.05). Surgical risk did not differ according to age.\ud CONCLUSIONS:\ud EO-IBD exhibits an extensive phenotype and benefit from aggressive treatment strategies, although surgical risk is similar to later-onset disease. A family history for IBD is not common in EO disease

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Section: Discussioncontrasting

confidence: 99%

Phenotype and Disease Course of Early-onset Pediatric Inflammatory Bowel Disease

Aloi

Lionetti

Barabino

et al. 2014

Inflammatory Bowel Diseases

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128

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“…Although published data (17–19) report a higher likelihood of a positive family history for IBD in younger patients, we found relatively low rates of family history in both groups. UC and IBD‐U were the most common phenotypes observed in VEO‐IBD children at baseline.…”

Section: Discussioncontrasting

confidence: 93%

Clinical Course of Very Early-Onset Inflammatory Bowel Disease

Cucinotta

Arrigo

Dipasquale

et al. 2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Objectives: Data on the phenotypes and disease outcomes of very early-onset inflammatory bowel disease (VEO-IBD) are limited. The aims of this study were to describe the clinical features, outcomes, and treatment response of VEO-IBD patients and to compare them with later-onset pediatric inflammatory bowel disease (P-IBD) patients. Methods: All consecutive patients aged 0–6 years who were diagnosed with Crohn disease (CD), ulcerative colitis, or IBD unclassified (IBD-U) at 2 academic hospitals from 2010 to March 2021 were included. They were compared to sex-matched IBD patients aged 6–17 years. Results: Two hundred thirty-two patients were included, 78 (34%) with VEO-IBD and 154 (66%) with P-IBD. IBD-U was the most common diagnosis in the VEO-IBD group compared to P-IBD (28% vs 3%, P < 0.001), while CD was predominant in older children (27% vs 52%, P < 0.001). The VEO-IBD group showed lower rates of clinical remission after induction with steroids compared to older children (82% vs 93%, P = 0.01), higher rates of steroid resistance (14% vs 5%, P = 0.02), and steroid dependence (27% vs 8%, P < 0.001). The number of patients who started anti-tumor necrosis factor (TNF)-α agents was similar between the groups. Anti-TNF-α retention was lower in the VEO-IBD group at 1 and 2 years (59% vs 85%, P = 0.003; 16% vs 55%, P < 0.001, respectively). Surgical risk appeared to be higher for VEO-IBD (32% vs 14%, P < 0.001). Conclusions: When compared to P-IBD patients, patients with VEO-IBD may have a more severe disease course, a poorer response to steroids and anti-TNF-α agents, and require more frequent surgical procedures.

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“…Some studies reported that alcohol is a sulfur and sulfate producer, thus increasing the concentration of fecal hydrogen sulfide (an agent toxic to colonocytes) [18–20]. Patients with IBD in Asia tend to have a lower positive family history rate (0.0–3.4%) than those in Western countries (10–25%) [2, 21, 22]. The rate of positive family history of IBD (4.2%) in our study was consistent with that in other Asian reports.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and Clinical Outcomes of Inflammatory Bowel Disease: A Hospital-Based Study in Central Taiwan

Chou

Lai

Chang

et al. 2019

Gastroenterology Research and Practice

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The incidence and prevalence of inflammatory bowel disease (IBD) are low but increasing in Taiwan. We aimed to investigate the epidemiology and clinical outcomes of IBD in central Taiwan. We retrospectively analyzed patients with IBD diagnosed at our hospital between January 2000 and September 2018. The diagnostic criteria were based on endoscopic and pathologic findings. Clinical characteristics, treatment regimens, and treatment outcomes were analyzed. A total of 190 patients with IBD were enrolled (80 with Crohn’s disease (CD) and 110 with ulcerative colitis (UC)). The mean age at diagnosis was 38.4 years (CD: 36 years, UC: 40 years). Male patients accounted for the majority of patients (71.1%). The male-to-female ratio was 3 : 1 for CD and 2.1 : 1 for UC. Current and ever smokers accounted for 30.5% of all patients. Only 4.2% of patients had a family history of IBD. Extraintestinal manifestations (EIMs) were reported in 7.9%, and colorectal cancers (CRCs) were reported in 2.1% of all patients. In patients with CD, the ileal type was the most common disease phenotype (57.5%), and the stricturing type was the most common disease behavior (60.0%). In patients with UC, left-sided colitis was the predominant disease extent (42.7%). The seroprevalence of hepatitis B virus (HBV) was 13.3%. The incidence of perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA) in patients with UC was 22%. 5-Aminosalicylic acids were the preferred treatment for UC, whereas corticosteroids, immunomodulators, and biologic agents were preferred for CD. In patients with CD, the bowel resection rate was 38.8%, and the incidence of hip avascular necrosis was 3.8%. In Taiwan, patients with IBD showed a male predominance, lack of familial clustering, a higher prevalence of HBV infection, and a lower prevalence of p-ANCA, EIMs, and CRC. Moreover, a higher incidence of the ileal type with poor outcomes of CD and left-sided predominance in UC were found.

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Family history in early-onset inflammatory bowel disease

Cited by 5 publications

References 6 publications

Phenotype and Disease Course of Early-onset Pediatric Inflammatory Bowel Disease

Phenotype and Disease Course of Early-onset Pediatric Inflammatory Bowel Disease

Clinical Course of Very Early-Onset Inflammatory Bowel Disease

Epidemiology and Clinical Outcomes of Inflammatory Bowel Disease: A Hospital-Based Study in Central Taiwan

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