Family History Is a Strong Risk Factor for Prevalent Angle Closure in a South Indian Population

Srinivasan, Kavitha; Zebardast, Nazlee; Palaniswamy, Krishnamurthy; Wojciechowski, Robert; Chan, Eugene; Friedman, David S.; Venkatesh, Rengaraj; Ramulu, Pradeep Y.

doi:10.1016/j.ophtha.2014.05.001

Cited by 66 publications

(27 citation statements)

References 21 publications

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“…They are the first degree relatives of existing glaucoma patients. Given the high rate of glaucoma among family members of those with OAG and angle closure glaucoma [25], we called 300 family members of our glaucoma patients to see if they were under observation or care. While most reported that they had had an eye exam within the last year, more than half did not recognize a visual field test when we asked if they had had an exam with a light flashing in a bowl-shaped device and pressed on a button.…”

Section: Retaining the Lost Sheepmentioning

confidence: 99%

21st century glaucoma care

Quigley

2018

Eye

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Glaucoma care has evolved dramatically over the past generation, with changes that have incorporated new technology and improved understanding of the disease process. A major need is to construct a useful definition of glaucomatous optic neuropathy that can be used to compare data across clinical research studies. The treatment of glaucoma should now be based on achievement of a goal target for intraocular pressure, unique to each patient. Adherence with eye drop treatment is far from ideal and can be improved using reminder systems. Sustained delivery of glaucoma medication is on the horizon. New surgical approaches to glaucoma are being actively studied but have not as yet found their place in its care, with rigorous testing against present treatments needed.

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Section: Retaining the Lost Sheepmentioning

confidence: 99%

21st century glaucoma care

Quigley

2018

Eye

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“…The study found that odds of developing narrow angles were nearly 14 times greater among these siblings than in the general population, with a greater than 1 in 3 risk of angle closure (Kavitha et al. ). Though imperfectly understood, the familial connection is clear, and siblings may benefit from PACG screening.…”

Section: Epidemiologymentioning

confidence: 99%

Primary angle‐closure glaucoma: an update

Wright

Tawfik

Waisbourd

et al. 2015

Acta Ophthalmologica

171

118

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ABSTRACT. Primary angle-closure glaucoma is potentially a devastating disease, responsible for half of glaucoma-related blindness worldwide. Angle closure is characterized by appositional approximation or contact between the iris and trabecular meshwork. It tends to develop in eyes with shallow anterior chambers, anteriorly positioned or pushed lenses, and angle crowding. Risk of primary angle-closure glaucoma is high among women, the elderly and the hyperopic, and it is most prevalent in Asia. Investigation into genetic mechanisms of glaucoma inheritance is underway. Diagnosis relies on gonioscopy and may be aided by anterior segment optical coherence tomography and ultrasound biomicroscopy. Treatment is designed to control intraocular pressure while monitoring changes to the angle and optic nerve head. Treatment typically begins with medical management through pressurereducing topical medications. Peripheral iridotomy is often performed to alleviate pupillary block, while laser iridoplasty has been found effective for mechanisms of closure other than pupillary block, such as plateau iris syndrome. Phacoemulsification, with or without goniosynechialysis, both in eyes with existing cataracts and in those with clear lenses, is thus far a viable treatment alternative. Long-term research currently underway will examine its efficacy in cases of angle closure in early stages of the disease. Endoscopic cyclophotocoagulation is another treatment option, which can be combined with cataract surgery. Trabeculectomy remains effective therapy for more advanced cases.

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“…Although family history is known to be a risk factor for glaucoma, including POAG and PACG (Kavitha et al, 2014;Kong et al, 2011;Sun et al, 2012), cases of POAG caused by a single gene mutation have been considered to account for only a small portion of all POAG cases. Many researchers have focused on gene expression or the function or structure of specific proteins in multiple glaucoma-related tissues; the candidate gene approach was performed.…”

Section: Association Studies For Poagmentioning

confidence: 99%