Family history of cancer among cases of upper urothelial tumours in a Balkan nephropathy area

Radovanović, Zoran; Krajinović, S; Janković, Slavenka; Hall, Phillip M.; Petković, S

doi:10.1007/bf00402737

Cited by 22 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In accordance with Takahashi et al (2001), we believe that there are biologically and also clinically important di erences between the urothelium of the upper and lower urinary tract, which may be just due to di erent degrees of exposure to carcinogens. In Balkan endemic nephropathy the risk of upper urinary tract, but not bladder cancers is increased (Radovanovic et al, 1985). The recent clinical insights in HNPCC-related tumor entities seems to group upper urinary tract tumors in the category of HNPCC-related tumors (Aarnio et al, 1995;Arzimanoglou et al, 1998), while lower urinary tract tumors show no relation to genetic tumor patterns, thus highlighting biological dissimilarities in di erent urothelial sites.…”

mentioning

confidence: 99%

Evidence for oligoclonality and tumor spread by intraluminal seeding in multifocal urothelial carcinomas of the upper and lower urinary tract

et al. 2001

View full text Add to dashboard Cite

Multifocality and recurrence of urothelial carcinoma may result from either the ®eld e ect of carcinogens leading to oligoclonal tumors or monoclonal tumor spread. Previous molecular studies, favoring the monoclonality hypothesis, are mostly limited to the urinary bladder. We investigated genetic alterations in a total of 94 synchronous or metachronous multifocal tumors from 19 patients with at least one tumor both in the upper and lower urinary tract. Loss of heterozygosity (LOH) was determined using eight markers on chromosome 9 and one marker on 17p13 (p53). Microsatellite instability was investigated at six loci and protein expression of MSH2 and MLH1 was evaluated by immunohistochemistry. In addition, exons 5 ± 9 of the p53 gene were sequenced. Deletions at chromosome 9 were found in 73% of tumors and at 17p13 in 18% of tumors. There was no signi®cant di erence in the frequency of LOH in the upper and lower urinary tract. Deletions at 9p21 were signi®cantly correlated with invasive tumor growth. The pattern of deletion revealed monoclonality of all tumors in nine patients. In ®ve patients there were at least two tumor clones with di erent genetic alterations. In four of these patients the di erent clones occured in the bladder and subsequently in the ureter and renal pelvis. All four patients with p53 mutations revealed identical mutations in all tumors. Thus, multifocal urothelial carcinomas are frequently monoclonal, whereas others show oligoclonality, providing molecular evidence for ®eld cancerization. Intraluminal tumor cell seeding appears to be an important mechanism of multifocal occurence and recurrence of urothelial carcinomas. Oncogene (2001) 20, 4910 ± 4915.

show abstract

mentioning

confidence: 99%

Evidence for oligoclonality and tumor spread by intraluminal seeding in multifocal urothelial carcinomas of the upper and lower urinary tract

et al. 2001

View full text Add to dashboard Cite

show abstract

“…Similar to bladder carcinoma, smoking and occupational exposure to arylamines are well-established risk factors for upper tract urothelial carcinoma accounting for the majority of cases (2). There are also unusual exogenous carcinogenic factors unique to the upper urothelial tract, including analgesic nephropathy (3,4) and Balkan nephropathy (5,6). The 5-year cancer-specific survival for upper tract urothelial carcinoma in the United States approaches 75%, and stage and grade are the most powerful predictors of survival (1).…”

mentioning

confidence: 99%

Upper Tract Urothelial Carcinoma: A Clinicopathologic Study Including Microsatellite Instability Analysis

et al. 2002

View full text Add to dashboard Cite

Urothelial carcinoma of the renal pelvis and ureter may develop as a manifestation of the hereditary nonpolyposis colorectal cancer syndrome that is characterized by mutations in a number of DNA mismatch repair genes and detectable as microsatellite instability. In this study, we examined microsatellite instability and the clinicopathologic features of urothelial carcinoma of the renal pelvis (n ‫؍‬ 61) and ureter (n ‫؍‬ 53) from 114 consecutive patients surgically treated from 1985-1992. Clinical data were obtained through chart review. Matched normal and tumor DNA was extracted from paraffin-embedded tissue, and a panel of six microsatellite loci was analyzed. The male-female ratio was 2.8:1 with a median age of 70 years (range, 28 to 92 y). Microsatellite analysis was successful in 67 tumors, and 21 (31.3%) patients had tumors that exhibited microsatellite instability. Patients with microsatellite-unstable tumors were significantly more likely to have additional nonurologic cancers (P ‫؍‬ .015) including colorectal carcinoma (P ‫؍‬ .001) compared with patients with tumors that did not exhibit microsatellite instability. In addition, patients with microsatellite-unstable tumors showed more colorectal cancers in their family (P ‫؍‬ .026) and were more likely to have higher grade urothelial carcinoma of the upper tract (P ‫؍‬ .028). Grade and stage, but not microsatellite status, were the strongest predictors of cancer-specific survival. This study found the highest frequency of microsatellite instability in upper urothelial tract carcinomas reported to date and highlights upper tract urothelial carcinoma as a marker of the hereditary nonpolyposis colorectal cancer syndrome in some patients. These findings reinforce the importance of obtaining cancer histories in patients with upper tract urothelial carcinoma to subsequently identify individuals with the hereditary nonpolyposis colorectal cancer syndrome and at-risk relatives for surveillance and management programs.

show abstract

“…Furthermore, there is considerable geographic variability, with the highest reported incidence occurring in Balkan countries, associated with a degenerative interstitial nephropathy. [6] Staging and grading of upper tract TCC is similar to that of bladder cancer, though due to the relative thinness of the ureter's muscle layer, ureteric tumors are more likely to be invasive at presentation. [7] Upper tract TCC most commonly presents either with macroscopic or microscopic hematuria, or is discovered during follow-up imaging of patients with bladder TCC.…”

Section: Discussionmentioning

confidence: 99%

Postoperative distal ureteric and bladder cuff recurrence in a Grade I renal transitional cell carcinoma diagnosed and restaged by fluorodeoxyglucose positron emission tomography-computed tomography

et al. 2014

View full text Add to dashboard Cite

A 56-year-old male having Grade I transitional cell carcinoma (TCC) of left kidney, postleft nephrectomy and upper 1/3rd ureterectomy presented with painless hematuria. Restaging fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) revealed abnormal linear FDG uptake in the lower 2/3rd of the left ureter and in the bladder adjacent to the left vesicoureteric junction, no locoregional adenopathy nor distant metastases (Figures 1 and 2- left column). Patient underwent left lower ureterectomy with partial cystectomy. Postoperative histopathology was TCC. Instillation of Bacillus Calmette-Guérin injection in the bladder was done postoperatively. A follow-up FDG PET/CT scan performed 3 months postoperatively was revealed no abnormal focal FDG uptake in the whole body revealing disease free status. FDG PET was helpful in diagnosing tumor recurrence in the distal remnant ureter. This case attempts to highlight the role of FDG PET/CT in follow-up, residual and recurrence evaluation.

show abstract

Family history of cancer among cases of upper urothelial tumours in a Balkan nephropathy area

Cited by 22 publications

References 5 publications

Evidence for oligoclonality and tumor spread by intraluminal seeding in multifocal urothelial carcinomas of the upper and lower urinary tract

Evidence for oligoclonality and tumor spread by intraluminal seeding in multifocal urothelial carcinomas of the upper and lower urinary tract

Upper Tract Urothelial Carcinoma: A Clinicopathologic Study Including Microsatellite Instability Analysis

Postoperative distal ureteric and bladder cuff recurrence in a Grade I renal transitional cell carcinoma diagnosed and restaged by fluorodeoxyglucose positron emission tomography-computed tomography

Contact Info

Product

Resources

About