Family history of cancer in children with acute leukemia, Hodgkin's lymphoma or non‐Hodgkin's lymphoma: The ESCALE study (SFCE)

Rudant, Jérémie; Ménégaux, Florence; Leverger, Guy; Baruchel, André; Nelken, Brigitte; Bertrand, Yves; Hartmann, Olivier; Pacquement, Hélène; Vérité, Cécile; Robert, Alain; Gautier, Michel; Margueritte, Geneviève; Gandemer, Virginie; Hémon, Denis; Clavel, Jacqueline

doi:10.1002/ijc.22624

Cited by 37 publications

(31 citation statements)

References 32 publications

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“…15 We found some evidence of an elevated risk of CNS tumors in relatives of children with CNS tumors. This is consistent with previous studies in which excesses of cancer, and especially of CNS tumors, have been observed frequently in siblings and occasionally in parents of probands with a childhood CNS tumor.…”

Section: Discussionmentioning

confidence: 66%

“…These have included analyzing cancer mortality rather than incidence, 5,10 not considering cancer among adult relatives, 10,11 not being population-based, 4 restricting probands to children who survived at least 5 years from diagnosis, 4 relying on questionnaire responses rather than record linkage for ascertainment of cancers in family members 4 and only reporting risk estimates for specific cancer types in first-and second-degree relatives combined in case-control studies, implying that reports of cancer in first-degree and more distant relatives might be considered to be equally reliable. [13][14][15] Therefore, we explored familial aggregation of cancer in a large populationbased retrospective case-control study designed to overcome some of these limitations.…”

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confidence: 99%

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Familial aggregation of childhood and adult cancer in the Utah genealogy

Neale

Stiller

Bunch

et al. 2013

Intl Journal of Cancer

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A small proportion of childhood cancer is attributable to known hereditary syndromes, but whether there is any familial component to the remainder remains uncertain. We explored familial aggregation of cancer in a population-based case-control study using genealogical record linkage and designed to overcome limitations of previous studies. Subjects were selected from the Utah Population Database. We compared risk of cancer in adult first-degree relatives of children who were diagnosed with cancer with the risk in relatives of children who had not had a cancer diagnosed. We identified 1,894 childhood cancer cases and 3,788 controls; 7,467 relatives of cases and 14,498 relatives of controls were included in the analysis. Relatives of children with cancer had a higher risk of cancer in adulthood than relatives of children without cancer [odds ratio (OR) 1.31, 95% confidence interval (CI) 1.11-1.56]; this was restricted to mothers and siblings and was not evident in fathers. Familial aggregation appeared stronger among relatives of cases diagnosed before 5 years of age (OR 1.48, 95% CI 1.13-1.95) than among relatives of cases who were older when diagnosed (OR 1.22, 95% CI 0.98-1.51). These findings provide evidence of a generalized excess of cancer in the mothers and siblings of children with cancer. The tendency for risk to be higher in the relatives of children who were younger at cancer diagnosis should be investigated in other large data sets. The excesses of thyroid cancer in parents of children with cancer and of any cancer in relatives of children with leukemia merit further investigation.The causes of childhood cancer are largely unknown. A small proportion of cases are attributable to known hereditary cancer syndromes, but whether there is any familial component to the remainder remains uncertain. Understanding familial risks may help to further elucidate etiology and/or identify the need to screen family members.Little 1 reviewed much of the already extensive literature published to 1997 on aggregation of cancer among firstdegree relatives of children with cancer. Many of these studies involved a relatively small number of cases, and Little concluded that there was no strong evidence of familial risks in parents or siblings for most of the common types of childhood cancer. Since then, several large studies of cancer risk in first-degree relatives of children with cancers of all types have emerged from the Nordic countries, 2 the United Kingdom, 3 the United States 4 and Italy. 5,6 Analyses of risk for many types of childhood cancer have also been published from the Swedish Family Cancer Database. 7-9 There has been broad agreement that overall the risk of childhood cancer in the siblings of children with cancer is moderately increased. 2,10,11 In a population-based study in the Nordic countries, there was a small increase in the risk of cancer in siblings of all ages combined, but this was entirely accounted for by known familial cancer syndromes. 2 Conversely, a North American study of the siblings of 5-y...

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Section: Discussionmentioning

confidence: 66%

mentioning

confidence: 99%

Familial aggregation of childhood and adult cancer in the Utah genealogy

Neale

Stiller

Bunch

et al. 2013

Intl Journal of Cancer

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“…Some smaller studies have reported larger ORs for risk of HL with a family history of HL. 28,29 These data provide strong evidence for familial predisposition to lymphoma. However, the case-control study design is susceptible to several types of bias, particularly selection and reporting bias.…”

Section: Evidence For Familial Predisposition Twin Studiesmentioning

confidence: 63%

Familial predisposition and genetic risk factors for lymphoma

Cerhan¹,

Slager

2015

Blood

143

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Our understanding of familial predisposition to lymphoma (collectively defined as non-Hodgkin lymphoma [NHL], Hodgkin lymphoma [HL], and chronic lymphocytic leukemia [CLL]) outside of rare hereditary syndromes has progressed rapidly during the last decade. First-degree relatives of NHL, HL, and CLL patients have an ∼1.7-fold, 3.1-fold, and 8.5-fold elevated risk of developing NHL, HL, and CLL, respectively. These familial risks are elevated for multiple lymphoma subtypes and do not appear to be confounded by nongenetic risk factors, suggesting at least some shared genetic etiology across the lymphoma subtypes. However, a family history of a specific subtype is most strongly associated with risk for that subtype, supporting subtype-specific genetic factors. Although candidate gene studies have had limited success in identifying susceptibility loci, genome-wide association studies (GWAS) have successfully identified 67 single nucleotide polymorphisms from 41 loci, predominately associated with specific subtypes. In general, these GWAS-discovered loci are common (minor allele frequency >5%), have small effect sizes (odds ratios, 0.60-2.0), and are of largely unknown function. The relatively low incidence of lymphoma, modest familial risk, and the lack of a screening test and associated intervention, all argue against active clinical surveillance for lymphoma in affected families at this time.

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“…The design of the study has already been published elsewhere [6]. The cases were all For ethical reasons, children who had died or who were receiving palliative care before the inclusion date were not eligible.…”

Section: Study Population and Data Collectionmentioning

confidence: 99%