Family History of Dementia: Dementia With Lewy Bodies and Dementia in Parkinson’s Disease

Papapetropoulos, Spiridon; Lieberman, Abraham; Gonzalez, Jocely; Singer, Carlos; Laufer, Daniel; Mash, Deborah C.

doi:10.1176/jnp.18.1.113

Cited by 10 publications

(9 citation statements)

References 12 publications

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“…About half of the DLB patients in this study had at least one first degree relative with dementia or PD. This is in line with previous studies, in which a positive family history for dementia was observed in 39-44% and for PD in 10-24% of patients with DLB [10,11]. Nonetheless, the percentages that we found could be an overestimation as patients with insufficient information on family history were not taken into account.…”

Section: Discussionsupporting

confidence: 91%

“…However, it has been reported that siblings of DLB patients are at higher risk of developing DLB compared to siblings of AD patients [9]. Furthermore, DLB patients more often have a family history of PD or dementia than controls [10,11]. This finding supports the notion that DLB, PD and dementia share, at least partially, the same genetic factors.…”

Section: Introductionsupporting

confidence: 58%

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Family History is Associated with Phenotype in Dementia with Lewy Bodies

Vergouw

Bosman

Beek

et al. 2020

JAD

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It is currently unknown whether patients with dementia with Lewy bodies (DLB) with relatives with dementia or Parkinson's disease (familial DLB patients) have a different phenotype than sporadic DLB patients. In this study, we aimed to examine disease onset, rate of cognitive decline, survival and Alzheimer's disease (AD) biomarkers in patients with dementia with Lewy bodies (DLB) with a family history of dementia or Parkinson's disease (familial DLB, n = 154) and sporadic DLB patients (n = 137), using linear mixed model analysis and Cox regression analysis, among others. Familial patients had a shorter survival (8.0 years) and more often elevated cerebrospinal fluid AD biomarkers (47%) than sporadic patients (9.0 years; p ≤ 0.001; 30%, p = 0.037). Our findings suggest that genetic factors are important in DLB and that the identification of new genetic factors will probably improve the prediction of prognosis.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionsupporting

confidence: 58%

Family History is Associated with Phenotype in Dementia with Lewy Bodies

Vergouw

Bosman

Beek

et al. 2020

JAD

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“…Woodruff et al reported a higher percentage of patients with autopsy-confirmed LBD (n = 18) had a family history of dementia (67%) compared to healthy controls (13%) 34 and Papapetropoulos et al reported a family history of dementia was significantly more frequent in DLB subjects (n = 25) compared to PD subjects (n = 64) both with and without dementia and healthy controls. 35 However, Boot et al did not find family history of dementia to be a risk factor for DLB. 5 In line with this research, we found family history of dementia did not predict earlier onset of LBD.…”

Section: Discussionmentioning

confidence: 95%

“…reported a higher percentage of patients with autopsy‐confirmed LBD (n = 18) had a family history of dementia (67%) compared to healthy controls (13%) and Papapetropoulos et al. reported a family history of dementia was significantly more frequent in DLB subjects (n = 25) compared to PD subjects (n = 64) both with and without dementia and healthy controls . However, Boot et al.…”

Section: Discussionmentioning

confidence: 97%

Risk factors for earlier dementia onset in autopsy‐confirmed Alzheimer's disease, mixed Alzheimer's with Lewy bodies, and pure Lewy body disease

Schaffert

LoBue

White

et al. 2020

Alzheimer's & Dementia

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Introduction Clinical Alzheimer's disease (AD) and dementia with Lewy bodies often have mixed AD and Lewy pathology, making it difficult to delineate risk factors. Methods Six risk factors for earlier dementia onset due to autopsy‐confirmed AD (n = 647), mixed AD and Lewy body disease (AD + LBD; n = 221), and LBD (n = 63) were entered into multiple linear regressions using data from the National Alzheimer's Coordinating Center. Results In AD and AD + LBD, male sex and apolipoprotein E (APOE) ɛ4 alleles each predicted a 2‐ to 3‐year‐earlier onset and depression predicted a 3‐year‐earlier onset. In LBD, higher education predicted earlier onset and depression predicted a 5.5‐year‐earlier onset. Discussion Male sex and APOE ɛ4 alleles increase risk for earlier dementia onset in AD but not LBD. Depression increases risk for earlier dementia onset in AD, LBD, and AD + LBD, but evaluating the course, treatment, and severity is needed in future studies.

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“…location and subtypes of dopaminergic receptors affected) that render patients with dementia less responsive to the pharmacological effects of LD 32, 33, 35–37. In a comparison of PD, PDD, and DLB, Papapetropoulos et al found a lower rate of dyskinesias among DLB patients (16%) compared to PDD (42%) or PD (48%) 38. Others have also reported that dyskinesias occur less often in DLB patients compared to the PDD and PD patients, and this observation may reflect differences in the sensitivity of these patients to dopaminergic medication.…”

Section: Resultsmentioning

confidence: 99%

Levodopa responsiveness in disorders with parkinsonism: A review of the literature

2007

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A literature review was conducted to investigate whether or not levodopa (LD) responsiveness (LR) is a useful criterion in the diagnosis of parkinsonian disorders. Although LR does appear to differ among the parkinsonian disorders, there is considerable confusion in the literature. While most patients with Parkinson's disease (PD) have a sustained benefit from LD, a small minority of patients with documented PD do not respond. The literature suggests that the LR rate is higher for multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD) than based on published diagnostic criteria. Magnitude and duration of response to LD and tolerability (time course, type and distribution of dyskinesias, mental effects and motor worsening) may be useful features in distinguishing PD, MSA, PSP, and CBD. Efforts should be directed toward better defining LR when used for diagnostic purposes and in scientific publications.

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Family History of Dementia: Dementia With Lewy Bodies and Dementia in Parkinson’s Disease

Cited by 10 publications

References 12 publications

Family History is Associated with Phenotype in Dementia with Lewy Bodies

Family History is Associated with Phenotype in Dementia with Lewy Bodies

Risk factors for earlier dementia onset in autopsy‐confirmed Alzheimer's disease, mixed Alzheimer's with Lewy bodies, and pure Lewy body disease

Levodopa responsiveness in disorders with parkinsonism: A review of the literature

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