Family History of Myocardial Infarction and Cause-Specific Risk of Myocardial Infarction and Venous Thromboembolism

Lind, Caroline; Enga, Kristin F.; Mathiesen, Ellisiv B.; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John‐Bjarne

doi:10.1161/circgenetics.114.000621

Cited by 21 publications

(31 citation statements)

References 43 publications

(64 reference statements)

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“…Different VTE manifestations and varicose veins also partially share familial susceptibility 2. However, CHD and ischaemic stroke do not share strong familial susceptibility with VTE in two nationwide family studies,4 5 though an association between VTE and MI has been reported in the Tromsø study 3 6. Our study adds to these previous findings that indicated that most arterial thromboembolic manifestations do not share familial susceptibility with VTE.…”

Section: Discussionmentioning

confidence: 39%

A nationwide family study of venous thromboembolism and risk of arterial vascular disease

Zöller

Sundquist

et al. 2016

Heart

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Section: Discussionmentioning

confidence: 39%

A nationwide family study of venous thromboembolism and risk of arterial vascular disease

Zöller

Sundquist

et al. 2016

Heart

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“…In an attempt to determine the impact of cardiovascular risk factors, including family history of myocardial infarction, on the incidence of VTE, investigators from Norway extracted data from more than 21 000 subjects, aged 25-96 years, who had been enrolled in a prospective, population-based study (the Tromsø Study) [35,36] . In multivariable analysis, family history of myocardial infarction was significantly associated not only with an increased risk of infarction but also of total VTE (HR, 1.27; 95% CI 1.01-1.60) and unprovoked VTE (HR, 1.46; 95% CI: 1.03-2.07.…”

Section: Is Atherosclerosis Predictive Of Vte?mentioning

confidence: 99%

Venous and Arterial Thrombosis: Is there a Link?

Prandoni

Milan

Vedovetto

et al. 2015

International Journal of Hematology Research

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Following the demonstration that patients with deep venous thrombosis of the lower extremities have a significant higher prevalence of carotid plaques than matched control individuals, numerous studies have consistently shown that patients with venous thromboembolism -especially those with events of unknown origin -have a remarkably higher risk of developing subsequent arterial thrombotic events than control subjects. The two vascular disorders share several risk factors (including age, obesity, smoking habit, diabetes mellitus, hypertension, hypertriglyceridemia, and metabolic syndrome) and the abnormal elevation of markers of endothelial dysfunction (such as microalbuminuria and the plasma levels of soluble P-selectin and von Willebrand factor). These findings have potential implications for both research and medical practice. Patients with venous thromboembolism could be examined for asymptomatic atherosclerosis, in order to modify the risk profile in those with abnormal test results. Measures could include appropriate counseling about lifestyle changes, control of risk factors for atherosclerosis and the use of drugs, such as statin and aspirin, whose effectiveness in reducing the risk not only of arterial but also of venous thrombotic disorders has recently been shown.

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“…A study [21], on the behalf of GISSI-EFRIM, investigates the association between family history of MI and risk of AMI [22][23][24][25]. These mentioned studies have reported that Family history of heart disease was a significant and independent risk factor of MI.…”

Section: Discussionmentioning

confidence: 99%

Non Clinical Risk Factors of Myocardial Infarction: A Meta-Analysis Approach

Mr¹,

Ansar²,

Hanif³

et al. 2017

J Biom Biostat

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IntroductionCardiovascular disease is a commonly used term that refers to the diseases that affect the heart and other parts of the cardiac system of the body. The cardiovascular diseases that affect the coronary arteries of the heart are called Coronary Heart Diseases (CHD) [1]. Myocardial Infarction (MI) is one of the diseases in this group. A large number of people die every year due to this fatal disease. In 2013, the number of people who died from cardiovascular disease (CVD) was more than 17.3 million (95% uncertainty interval, 16.5 to 18.1), representing an increase from 1990 of 40.8% [2]. The burden of Coronary Heart Disease is increasing at a greater rate in South Asian countries than the other countries of the world. It has been estimated that the risk of MI would be doubled in the next 20 years [3]. According to American Heart Association, approximately one of every six deaths in United States is caused by MI [4,5]. Another study showed that the high prevalence of MI in Pakistan with more than 30% of the population over 45 years of age is affected by this disease [3]. This statistics has revealed that this disease is growing at alarming rate in the world. A mammoth literature is available on this disease. As a result many medical, social, economic, demographic risk factors were explored in the literature.In this literature medical factors got significant attention by medical professionals and practitioners. The least attention has been paid to non-clinical factors (demographic and socioeconomic factors) which can play significant role in causing MI [6][7][8]. Age, gender and family history of MI are demographic factors and education is a socioeconomic factor. Age and gender has been found as powerful risk factors of MI [9]. It has also been observed that chances of getting MI increases as the age of the patients increases. Another study shows that MI in patients less than the age of 40 is 10% of all the cases [10]. A study conducted in Bangladesh shows that the incidence of AMI was more frequent among the patients of age group 50-59 years [11]. Recently a health survey conducted in England suggests that 4% of men and 0.5% of women have had an MI [12]; however, after the age of 70 both genders have equal chance of getting this disease. It has been observed that women have experienced their first MI on the average 9 years later than men [13].Family history of heart diseases has also emerged as an important predictor of MI in many studies. A family history of MI increases the risk of CHD especially for MI. The National Cholesterol Education Program highlights that an individual may have a positive history of MI if his close blood relative male (father or brother) has MI younger than 55 years or female (his mother or sister) has MI younger than 65 years [14]. AbstractBackground: Myocardial Infarction (MI) is a coronary heart disease that is one of the main causes of the mortality over the globe. There are various clinical and non-clinical risk factors that can be further classified as modifiable and non...

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Family History of Myocardial Infarction and Cause-Specific Risk of Myocardial Infarction and Venous Thromboembolism

Cited by 21 publications

References 43 publications

A nationwide family study of venous thromboembolism and risk of arterial vascular disease

A nationwide family study of venous thromboembolism and risk of arterial vascular disease

Venous and Arterial Thrombosis: Is there a Link?

Non Clinical Risk Factors of Myocardial Infarction: A Meta-Analysis Approach

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