Family History of Premature Death and Risk of Early Onset Cardiovascular Disease

Ranthe, Mattis F.; Carstensen, Lisbeth; Øyen, Nina; Tfelt-Hansen, Jacob; Christiansen, Michael; McKenna, William J.; Wohlfahrt, Jan; Melbye, Mads; Boyd, Heather A.

doi:10.1016/j.jacc.2012.06.018

Cited by 50 publications

(26 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The Causes of Death Register, which began in 1970, contains death certificate information, including contributing and underlying causes of death, main diseases and recent procedures and medication. 11,12 Study Cohort, Identification of Relatives, and…”

Section: Data Sourcesmentioning

confidence: 99%

“…As we have done previously, we excluded deaths that might possibly have been misclassified cardiac deaths (deaths due to stroke, cerebral hemorrhage, asthma, epilepsy, solo accidents, and unexplained causes) from both the cardiac and noncardiac categories. 12 We also examined 2 specific subgroups of cardiac death: premature deaths from ischemic heart disease (ICD-8 codes 410-414.99 and ICD-10 codes I20-I25.9) and premature deaths from cardiomyopathy (ICD-8 code 425.99 and ICD-10 codes I42-I43.8). Since ischemic heart disease can produce secondary cardiomyopathy, persons with both ischemic heart disease and cardiomyopathy diagnoses on the death certificate were classified as having died of ischemic heart disease.…”

Section: Assessment Of Premature Deaths Among Relativesmentioning

confidence: 99%

See 1 more Smart Citation

Risk of Cardiomyopathy in Younger Persons With a Family History of Death from Cardiomyopathy

et al. 2015

Self Cite

View full text Add to dashboard Cite

Background— Recommendations for presymptomatic screening of relatives of cardiomyopathy patients are based on findings from tertiary centers. Cardiomyopathy inheritance patterns are fairly well understood, but how cardiomyopathy in younger persons (<50 years) aggregates in families at the population level is unclear. In a nationwide cohort, we examined the risk of cardiomyopathy by family history of premature death (<60 years) from cardiomyopathy. Methods and Results— By linking Danish national register data, we constructed a cohort of 3.9 million persons born from 1950 to 2008. We ascertained family history of premature (<60 years) death from cardiomyopathy or other conditions, and cohort members were followed from 1977 to 2008 for cardiomyopathy diagnosed at <50 years. We identified 3890 cardiomyopathies in 89 million person-years of follow-up. Using Poisson regression, we estimated incidence rate ratios for cardiomyopathy by family history of premature death. Premature cardiomyopathy deaths in first- and second-degree relatives were associated with 29- and 6-fold increases in the rate of cardiomyopathy, respectively. If the first-degree relative died aged <35 years, the rate of cardiomyopathy increased 100-fold; given ≥2 premature deaths in first-degree relatives, the rate increased more than 400-fold. In contrast, a family history of premature death from other cardiac or noncardiac conditions increased the rate of cardiomyopathy 3-fold at most. Conclusions— A family history of premature cardiomyopathy death was associated with an increase in risk of cardiomyopathy ranging from 6- to 400-fold, depending on age, kinship, gender and number of affected family members. Our general population-based results support recommendations for presymptomatic screening of relatives of cardiomyopathy patients.

show abstract

Section: Data Sourcesmentioning

confidence: 99%

Section: Assessment Of Premature Deaths Among Relativesmentioning

confidence: 99%

Risk of Cardiomyopathy in Younger Persons With a Family History of Death from Cardiomyopathy

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…U skupinu nasljednih aritmogenih bolesti ubrajamo sindrom dugog (LQTS) i kratkog QT intervala (SQTS), Brugadin sindrom (BrS), kateholaminergiËnu polimorfnu ventrikulsku tahikardiju (CPVT), aritmogenu kardiomiopatiju desne klijetke (ARVC) te hipertrofijsku kardiomiopatiju (HCM) (vidi Slike 1-4). Nasljeuju se preteaeito autosomno dominantno, a bliaei su srodnici pod poviπenim rizikom za obolijevanje od istih bolesti 13,14 .…”

Section: Genetsko Testiranjeunclassified

“…The group of congenital arrhythmogenic diseases include long QT syndrome (LQTS) and short QT syndrome (SQTS), the Brugada syndrome (BrS), catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), arrhythmogenic right ventricular cardiomyopathy (ARVC) and hypertrophic cardiomyopathy (HCM) (Figures 1-4). They are inherited predominantly autosomally, while closer relatives are at increased risk of developing the same disease 13,14 . 15,16 .…”

Section: Genetic Testingmentioning

confidence: 99%

Arrhythmology and cardiac pacing – an overview of the situation in Croatia.

Brusich¹,

Vražić²

2014

Cardiol Croat.

View full text Add to dashboard Cite

2014;9(1-2):3.Cardiologia CROATICA UvodAritmologija se ubraja meu najkompleksnije i najzahtjevnije dijelove ne samo kardiologije, nego i cijele kliniËke medicine. Sve boljim razumijevanjem patofizioloπkih mehanizama aritmija i primjenom novih tehnoloπkih dostignuÊa znaËajno su se unaprijedile moguÊnosti lijeËenja bolesnika s poremeÊajima srËanog ritma. UnatoË brojnim problemima, a zahvaljujuÊi velikom trudu i entuzijazmu lijeËnika koji se bave ritmologijom u Republici Hrvatskoj, u zadnjih godina prati se znaËajan napredak u SAAEETAK: Unazad nekoliko godina prisutan je znaËa-jan napredak u zbrinjavanju bolesnika s poremeÊajima srËanog ritma, kako u svijetu, tako i u Republici Hrvatskoj. Ovaj pregledni Ëlanak prikazuje postojeÊe stanje u podruËju aritmologije i elektrostimulacije u Republici Hrvatskoj. NajveÊi napredak vidljiv je u podruËju elektrofiziologije znaËajnim poveÊanjem broja uËinjenih kateterskih ablacija aritmija, a osobito ablacije fibrilacije atrija. Prisutni su i znatni pomaci u novim spoznajama u podruËju elektrostimulacije, daljnji porast u brojnu centara gdje se takvi postupci provode, kao i u broju uËinjenih postupaka, pri Ëemu edukacija prati nove spoznaje i trendove, sve s ciljem kako bi naπim bolesnicima omoguÊili dulje preaeivljenje i bolju kvalitetu aeivota. Meutim, glavni izazovi koji ostaju pred nama nisu se bitno promijenili u odnosu na prijaπnje godine, a osnovno je pronalazak dodatnih sredstava koji bi osigurali bolju prevenciju nagle srËane smrti neophodnim poveÊanjem broja ugradnje implantabilnih kardioverter defibrilatora i ureaja za resinkronizacijsku terapiju. Prostor za poboljπa-nje je znatan, pri Ëemu se ne moaee dovoljno naglasiti vaaenost ustrajne aktivnosti struËnog druπtva u ovom podruËju. KLJU»NE RIJE»I: aritmologija, elektrofiziologija, elektrostimulacija srca, fibrilacija atrija. SUMMARY:In the past few years there has been a significant progress in the management of patients with heart rhythm disorders both in the world and in Croatia. This review article summarizes the current situation in the area of arrhythmology and cardiac pacing in the Republic of Croatia. The greatest improvement is seen in the field of electrophysiology due to a significant increase in the number of performed electrophysiological procedures, particularly catheter ablation of atrial fibrillation. There are also significant advancements in new insights in the field of electrical stimulation, a further increase in a number of centers where such procedures are performed, as well as in the number of performed procedures where education follows new insights and trends, all with an aim to enable our patients to have prolonged survival and a better quality of life. However, some major challenges we are facing have not significantly changed compared to the previous year, and the basic one is finding additional resources to ensure better prevention of sudden cardiac death by necessary increasing the implantation rate of implantable cardioverter defibrillators and cardiac resynchronization therapy device...

show abstract

“…A positive family history of cardiovascular disease is a component of all these guidelines and a widely studied factor for increased risk, especially if there is early onset of disease manifestations in first-degree relatives or other close family members [3]. The epidemiological background is that a number of chronic disease conditions tend to cluster in fami lies with an increased risk in first-degree relatives, but also an increased risk in second-degree relatives [4].…”

mentioning

confidence: 99%

Microbiota patterns and risk of cardiometabolic disease — opportunities for intervention?

Nilsson

2016

Arterial Hypertension

View full text Add to dashboard Cite

In every human being, there is a substantial proportion (1-2 kg) of total body weight constituted by the gut microbiota content in the gastro-intestinal system. Recent research findings, based on mapping of the microbiome, have stated that in healthy subjects, the gut microbiota richness and diversity is higher as compared to obese subjects or patients suffering from cardiometabolic disease, or even long-standing hypertension when a different and less rich pattern is seen (dysbiosis). Intervention with certain food constituents, e.g. Mediterranean diet or dairy products such as lactobacillae-containing yoghurt, holds promise that this could be of benefit for improved organ function, improved metabolism and lowering disease risk. Randomized, controlled intervention studies are needed to test the hypothesis that a reduction in dysbiosis induced by external dietary interventions could translate into health benefits.

show abstract

Family History of Premature Death and Risk of Early Onset Cardiovascular Disease

Cited by 50 publications

References 28 publications

Risk of Cardiomyopathy in Younger Persons With a Family History of Death from Cardiomyopathy

Risk of Cardiomyopathy in Younger Persons With a Family History of Death from Cardiomyopathy

Arrhythmology and cardiac pacing – an overview of the situation in Croatia.

Microbiota patterns and risk of cardiometabolic disease — opportunities for intervention?

Contact Info

Product

Resources

About