Family history of stroke in stroke types and subtypes

Polychronopoulos, Panagiotis; Gioldasis, G; Ellul, John; Metallinos, I. C.; Lekka, N.P.; Paschalis, C; Papapetropoulos, Thodoros

doi:10.1016/s0022-510x(01)00691-8

Cited by 66 publications

(63 citation statements)

References 33 publications

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“…Of these, 15 independent studies differentiated between ischemic and hemorrhagic strokes, ‡ and 4 studies subtyped ischemic strokes further into cardioembolic, large-artery disease, small-artery disease, and undetermined, 49,59 into cortical artery occlusion and perforating artery occlusion, 60 or included only patients with large-vessel stroke. 46 Most studies defined which relatives were considered in a family history (mostly FDR: parents and/or siblings), but 3 studies did not.…”

Section: Case-control Studiesmentioning

confidence: 99%

“…Two studies that investigated the influence of environmental factors other than smoking on family history of stroke as a risk factor for stroke found no significant association. 35,64 Tenʈ of 12 studies 56,59 investigating a possible interaction between family history of stroke and hypertension in patients found a significant association; 3 studies found an association with smoking, 35,44,52 3 found an association with diabetes mellitus, 37,44,52 4 found an association with the presence of ischemic heart disease or vascular disease, 31,37,46,52 and 1 found an association with the presence of hyperlipidemia. 42 Two studies found that family history of stroke was significantly related to a cluster of vascular risk factors.…”

Section: Case-control Studiesmentioning

confidence: 99%

“…42 Two studies found that family history of stroke was significantly related to a cluster of vascular risk factors. 42,37 Only 2 recent studies 49,59 compared the association of a positive family history of stroke between ischemic stroke subtypes. Their findings and the findings of 1 additional study 75 that did not include a control group and could therefore not be included in the meta-analysis are summarized in Table 5.…”

Section: Case-control Studiesmentioning

confidence: 99%

“…For instance, subarachnoid hemorrhage, which was included in some of the studies, might have a different genetic component compared with other strokes. 74,50 Many studies did not differentiate between ischemic and hemorrhagic stroke, and only 2 studies 49,59 subtyped ischemic stroke sufficiently to compare a family history between subtypes. Large-and small-vessel disease was more strongly associated with a positive family history of stroke than the remainder of ischemic strokes.…”

Section: Floßmann Et Al Genetic Epidemiology Of Ischemic Stroke 221mentioning

confidence: 99%

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Systematic Review of Methods and Results of Studies of the Genetic Epidemiology of Ischemic Stroke

Floßmann

Schulz

Rothwell

2004

Stroke

341

251

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Background and Purpose-To design appropriate molecular genetic studies, we first need to understand the genetic epidemiology of stroke. We therefore performed a systematic review of the literature to assess the heritability of stroke according to methodological quality of studies and to determine any heterogeneity in findings between studies and possible publication bias. Methods-We searched for twin studies and studies of family history of stroke using bibliographic databases and by hand-searching reference lists and journals. Odds ratios (ORs) for family history as a risk factor for stroke were calculated within studies and combined by meta-analysis. Heterogeneity between studies, methodological quality of studies, and the influence of the age at which stroke occurred in both probands and relatives were assessed. Results-We identified 53 independent studies (3 twin, 33 case-control, and 17 cohort). Monozygotic twins were more likely to be concordant than dizygotic twins (OR, 1.65; 95% CI, 1.2 to 2.3; Pϭ0.003). A positive family history was a risk factor for stroke in both case-control (OR, 1.76; 95% CI, 1.7 to 1.9; PϽ0.00001) and cohort (OR, 1.30; 95% CI, 1.2 to 1.5; PϽ0.00001) studies. However, there was major heterogeneity between studies (cohort Pϭ0.0001; case-control PϽ0.00001), with much stronger associations in small studies and methodologically less rigorous studies. Moreover, studies that reported insufficient data to allow meta-analysis tended to have found weaker associations. Family history of stroke was more frequent in studies that were confined to probands or relatives aged Ͻ70 years. However, few studies considered the number of affected and unaffected relatives, only 2 studies considered stroke phenotypes in detail, and only 19 studies (38%) adjusted associations for intermediate phenotypes.No twin study, only 5 cohort studies (26%), and 20 case-control studies (61%) differentiated between ischemic and hemorrhagic stroke in the proband. Family history of stroke was more frequent in large-and small-vessel stroke than in cardioembolic stroke. There were very few data on the influence of family history on stroke severity and no data on stroke recovery. Conclusions-Twin studies suggest a small genetic contribution to stroke, but reliable interpretation of published family history studies is undermined by major heterogeneity, insufficient detail, and potential publication and reporting bias.More detailed large-scale genetic epidemiology is required.

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Section: Case-control Studiesmentioning

confidence: 99%

Section: Case-control Studiesmentioning

confidence: 99%

Section: Case-control Studiesmentioning

confidence: 99%

Section: Floßmann Et Al Genetic Epidemiology Of Ischemic Stroke 221mentioning

confidence: 99%

See 2 more Smart Citations

Systematic Review of Methods and Results of Studies of the Genetic Epidemiology of Ischemic Stroke

Floßmann

Schulz

Rothwell

2004

Stroke

341

251

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“…Studies show that parental stroke is an independent risk factor for stroke (Jousilahti et al, 1997;Polychronopoulos et al, 2002) and, in those who have suffered a primary cerebrovascular event, there is evidence of an association between family history of stroke and modifiable risk (Flossmann and Rothwell, 2005;Lindgren et al, 2005). Lindgren found that first-degree relatives of people who had suffered a stroke reported a higher prevalence of hypertension than did relatives of controls who had not suffered a stroke (Lindgren et al, 2005), but this finding was not linked to any validated measurements.…”

Section: Introductionmentioning

confidence: 99%

The stroke offspring study: is parental stroke history of value in targeted risk factor screening?

Hart

Cupples

Wiggam

et al. 2010

Primary Health Care

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This study aimed to compare the prevalence of stroke risk factors among people with a parental history of stroke to those in a control group of individuals, of similar age, gender and social class, with no parental stroke history. Background: Parental stroke increases an individual's risk of stroke, but little is known of the potential value of using this information in targeted screening for primary prevention in general practice. Method: We sent questionnaires to 300 randomly selected individuals aged 40-65 years, in each of 11 different general practices in Northern Ireland. Among 1061 responses received within six weeks, 332 reported a parental history of stroke (31.3%). We matched respondents with (cases) and without (controls) a parental history of stroke on characteristics of age, gender and socioeconomic status. Matched pairs were invited to attend a consultation at which their diet and exercise habits were assessed using validated questionnaires and height, weight, blood pressure and serum lipids and glucose were measured. Findings: Matched data were available for 199 case-control pairs (398 individuals). Mean systolic and diastolic blood pressures were significantly higher in cases than in paired controls (systolic 146.3 versus 140.6 mmHg (P , 0.01); diastolic 87.7 versus 85.0 mmHg (P 5 0.014)). Cases consumed more alcohol than their paired controls (13.8 versus 10.1 U/week (P , 0.01)), but their measures of body mass index, lipids, diabetes, diet and exercise did not differ significantly. The results of this study suggest that screening offspring of patients with stroke in respect of blood pressure has potential value in identifying people likely to benefit from primary prevention, but do not support the adoption of a targeted screening strategy for other commonly cited stroke risk factors.

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Familial Occurrence and Heritability of Stroke

Aparicio,

Seshadri

2024

Stroke Genetics

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Family history of stroke in stroke types and subtypes

Cited by 66 publications

References 33 publications

Systematic Review of Methods and Results of Studies of the Genetic Epidemiology of Ischemic Stroke

Systematic Review of Methods and Results of Studies of the Genetic Epidemiology of Ischemic Stroke

The stroke offspring study: is parental stroke history of value in targeted risk factor screening?

Familial Occurrence and Heritability of Stroke

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