Family history of substance use disorder and likelihood of prescription drug misuse in adults 50 and older

Schepis, Ty S.; Wastila, Linda; McCabe, Sean Esteban

doi:10.1080/13607863.2022.2084711

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…Respondents with a positive family history of mental illness were twice as likely to use substances, while those with a family history of substance use were four times more likely to use substances compared to their counterparts. This association may be explained by common risk factors, such as genetic predisposition [50][51][52], contributing to both substance use and mental illness, although the exact mechanisms remain unknown. The bidirectional relationship between substance use and mental illness, where individuals using substances are more likely to experience mental illness and vice versa, emphasizes the interconnected nature of these issues [33].…”

Section: 3mentioning

confidence: 99%

Prevalence and Factors Associated with Self-Reported Substance Use among Patients with Mental Illness in Dar es Salaam, Tanzania: A Cross-Sectional Analytical Study

Karino,

Ambikile,

Iseselo

2023

Mental Illness

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Background. Substance use is prevalent among patients with mental illness in low- and middle-income countries, including Tanzania. This heightened prevalence not only increases the risk of developing mental disorders and substance use disorders but also contributes to poor treatment outcomes for these patients. Despite these concerns, the current prevalence of substance use and its associated factors in this population remains unclear in Tanzania. Therefore, this study is aimed at determining the 12-month period prevalence of self-reported substance use and associated factors among patients with mental illness. Methods. We conducted a cross-sectional analytical study among patients with mental illness at Muhimbili National Hospital in Dar es Salaam, Tanzania. Respondents were selected using a systematic random sampling technique. Data on self-reported substance use were collected using the World Health Organization’s (WHO) alcohol, smoking, and substance involvement screening test (ASSIST) V3.0. IBM SPSS version 25 was employed for data analysis, utilizing frequencies and percentages to determine the prevalence of self-reported substance use. The study employed bivariate and multiple logistic regression analyses to investigate the association between patient characteristics and self-reported substance use, with statistical significance set at a p value of < 0.05. Results. A total of 364 patients were enrolled in the study, with 215 (59.1%) being male and a mean (SD) age of 35.57 (±9.01) years. Among the participants, 119 (32.7%) reported substance use. The most commonly used substances were alcohol (21.7%), tobacco (19.8%), and cannabis (12.9%). Factors significantly associated with self-reported substance use included younger age (AOR: 1.829; 95% CI: 1.112, 3.010; p=0.017), male gender (AOR: 2.346; 95% CI: 1.397, 3.939; p=0.001), positive family history of mental illness (AOR: 2.247; 95% CI: 1.364, 3.701; p=0.001), and a family history of substance use (AOR: 3.804; 95% CI: 2.305, 6.276; p<0.001). Conclusions. A significant proportion, amounting to one-third of patients, reported substance use, highlighting the imperative need for targeted measures within this population. The implementation of routine substance use screening programs for patients with mental illness is crucial, alongside gender-sensitive and age-specific interventions. Consideration of patients’ family history of mental illness and substance use should be an integral part of these measures.

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Section: 3mentioning

confidence: 99%

Prevalence and Factors Associated with Self-Reported Substance Use among Patients with Mental Illness in Dar es Salaam, Tanzania: A Cross-Sectional Analytical Study

Karino,

Ambikile,

Iseselo

2023

Mental Illness

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Family history of substance problems among African Americans: Associations with drug use, drug use disorder, and prescription drug misuse

Mahrs-Gould,

Jallo,

Svikis

et al. 2024

Journal of Ethnicity in Substance Abuse

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The association between glucose‐dependent insulinotropic polypeptide and/or glucagon‐like peptide‐1 receptor agonist prescriptions and substance‐related outcomes in patients with opioid and alcohol use disorders: A real‐world data analysis

Qeadan,

McCunn,

Tingey

2024

Addiction

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AimsThis study aimed to estimate the strength of association between prescriptions of glucose‐dependent insulinotropic polypeptide (GIP) and/or glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) and the incidence of opioid overdose and alcohol intoxication in patients with opioid use disorder (OUD) and alcohol use disorder (AUD), respectively. This study also aimed to compare the strength of the GIP/GLP‐1 RA and substance use‐outcome association among patients with comorbid type 2 diabetes and obesity.DesignA retrospective cohort study analyzing de‐identified electronic health record data from the Oracle Cerner Real‐World Data.SettingAbout 136 United States of America health systems, covering over 100 million patients, spanning January 2014 to September 2022.ParticipantsThe study included 503 747 patients with a history of OUD and 817 309 patients with a history of AUD, aged 18 years or older.MeasurementsThe exposure indicated the presence (one or more) or absence of GIP/GLP‐1 RA prescriptions. The outcomes were the incidence rates of opioid overdose in the OUD cohort and alcohol intoxication in the AUD cohort. Potential confounders included comorbidities and demographic factors.FindingsPatients with GIP/GLP‐1 RA prescriptions demonstrated statistically significantly lower rates of opioid overdose [adjusted incidence rate ratio (aIRR) in OUD patients: 0.60; 95% confidence interval (CI) = 0.43–0.83] and alcohol intoxication (aIRR in AUD patients: 0.50; 95% CI = 0.40–0.63) compared to those without such prescriptions. When stratified by comorbid conditions, the rate of incident opioid overdose and alcohol intoxication remained similarly protective for those prescribed GIP/GLP‐1 RA among patients with OUD and AUD.ConclusionsPrescriptions of glucose‐dependent insulinotropic polypeptide and/or glucagon‐like peptide‐1 receptor agonists appear to be associated with lower rates of opioid overdose and alcohol intoxication in patients with opioid use disorder and alcohol use disorder. The protective effects are consistent across various subgroups, including patients with comorbid type 2 diabetes and obesity.

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Family history of substance use disorder and likelihood of prescription drug misuse in adults 50 and older

Cited by 3 publications

References 36 publications

Prevalence and Factors Associated with Self-Reported Substance Use among Patients with Mental Illness in Dar es Salaam, Tanzania: A Cross-Sectional Analytical Study

Prevalence and Factors Associated with Self-Reported Substance Use among Patients with Mental Illness in Dar es Salaam, Tanzania: A Cross-Sectional Analytical Study

Family history of substance problems among African Americans: Associations with drug use, drug use disorder, and prescription drug misuse

The association between glucose‐dependent insulinotropic polypeptide and/or glucagon‐like peptide‐1 receptor agonist prescriptions and substance‐related outcomes in patients with opioid and alcohol use disorders: A real‐world data analysis

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