We present an overview of the cross-cultural quality of survey reports of substance use behaviors in the United States. Empirical data from 36 published studies (1977-2003) are examined to evaluate the reliability and validity of substance use reports across cultural groups. In these studies, race/ethnicity are used as proxy indicators of respondent culture. In general, the available research suggests that, with a few exceptions, the quality of survey data on racial and ethnic disparities in substance use is often limited by differential measurement error. A conceptual paradigm is presented to consider a wide range of potential causes for these differences in measurement error that includes two dimensions: emphasis on negative vs. positive behavior patterns, and emphasis on internal vs. external causal factors. These two dimensions yield four potential models that are useful in understanding variations in substance use measurement error: the cultural deficit model, the cultural conflict model, the mainstream conformity model, and the cultural distrust model. Future research should focus on the ability of each of these alternative models to account for cultural variability in the quality of substance use reporting.