This article discusses the concept of prevention in drug abuse and explores the identification of risk and protective factors as crucial elements in addressing this pervasive issue. Drug abuse poses a significant threat to individuals, families, and communities, demanding comprehensive measures in response. Despite ongoing efforts, the problem persists, particularly among young people. The ever-increasing number of new and recurring cases necessitates a holistic approach to prevention. A key aspect is recognising the risks and protective factors that shape the effectiveness of these prevention programmes. These factors encompass various domains, including individual, peer, school, family, and community influences. Identifying and understanding these factors will assist social service practitioners, substance abuse counsellors, and researchers in developing targeted prevention programmes for drug and substance abuse, with a specific focus on youth.