Famotidine versus omeprazole in combination with clarithromycin and metronidazole for eradication of Helicobacter pylori—a randomized, controlled trial

Abstract

A 1-week course of clarithromycin and metronidazole in combination with a proton pump inhibitor is SUMMARY Background: One-week low-dose triple therapy is currently considered the gold standard regimen for treatment of Helicobacter pylori infection. However, the mechanisms involved in the synergy between antibiotics and proton pump inhibitors are controversial. Aims: To test the hypothesis that acid suppression represents the crucial mechanism by which the antibacterial activity of antibiotics can be enhanced, and to assess the impact of primary resistance on treatment outcome. Methods: One hundred and twenty patients with H. pylori infection and duodenal ulcer, gastric ulcer or non-ulcer dyspepsia were randomly assigned to a 1 week course of either famotidine 80 mg b.

Meta‐analysis: the effect of antibiotic resistance status on the efficacy of triple and quadruple first‐line therapies for Helicobacter pylori

“… ANB, 27–32 0, NTB, 27, 33–45 ANG, 33, 40 38, 41, 46–66 CNG, 22, 31, 53, 54, 57, 60–64, 67–90 ACG, 38, 59, 62, 63, 67, 70, 78, 84, 87, 91–105 MTBG, 34, 38, 39, 58, 99, 106–116 ACMG 82, 117 and CMBR 31, 67, 111, 113, 118 …”

“…Clarithromycin, nitroimidazole and a gastric acid inhibitor The most commonly tested regimen in our analysis treated 3128 subjects with clarithromycin, a nitroimidazole and a gastric acid inhibitor (CNG; Table 1). CNG treatment arms came from studies conducted in North America (two studies, 11 arms), South America (one study, two arms), Europe (21 studies, 58 arms), Asia (nine studies, 24 arms) and Australia (one study, four arms) 22, 31, 53, 54, 57, 60–64, 67–90 . The duration of CNG treatment ranged from 5 to 14 days.…”

Lafutidine, a Novel Histamine H2‐Receptor Antagonist, vs. Lansoprazole in Combination with Amoxicillin and Clarithromycin for Eradication of Helicobacter pylori

“…Some data have been published showing that good H. pylori eradication results can be achieved using H 2 receptor antagonist [9,10,12,28], but there are only a few reports in which proton pump inhibitor and H 2 receptor antagonist were compared in two study arms with the same selection of antibiotics [10–12,28]. A recent randomized, controlled trial showed that famotidine and omeprazole, combined with clarithromycin and metronidazole, were equivalent for cure of H. pylori infection [10]. In contrast, other data showed that ranitidine, when used together with amoxicillin and metronidazole, was less effective than omeprazole [12].…”

Strategy for Treatment of Helicobacter pylori Infection in Adults II. Practical Policy in 2000

“…For example, some randomized controlled studies showed the same eradication rates between PPIbased and H2RA-based 1-week triple therapies [65,66]. Meta-analytic studies have shown somewhat lower eradication rates in H2RA-based triple therapies than PPI-based triple therapies [33,67].…”