1996
DOI: 10.1128/jb.178.16.4759-4764.1996
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Fancy meeting you here! A fresh look at "prokaryotic" protein phosphorylation

Abstract: Bacteria play host to a wide range of protein phosphorylation-dephosphorylation systems (Fig. 1). As little as five years ago the known systems were thought to be late-emerging and absolutely prokaryote specific. Today we know that most protein kinases and protein phosphatases are descended from a set of common, and possibly quite ancient, prototypes. Prokaryote- and eukaryote-specific protein kinases and protein phosphatases are rare and represent exceptions, not the rule as previously thought. Commonality su… Show more

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Cited by 167 publications
(108 citation statements)
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“…There are examples of histidine kinase-related proteins in Bacillus subtilis (Yang et al 1996) and the eukaryotic mitochondrion (Popov et al 1992) that mediate phosphoserine formation. In addition, there have been reports of Ser/Thr or Tyr autophosphorylating proteins in bacteria (Ostrovsky and Maloy 1995;Grangeasse et al 1997).Recently, genes encoding proteins homologous to eukaryotic Ser/Thr protein kinases have been identified in several bacteria (Kennelly and Potts 1996) and archaea (Smith and King 1995). Myxococcus xanthus encodes numerous paralogous Ser/Thr kinases that show highly significant sequence similarity to one another (Munoz-Dorado et al 1993).…”
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confidence: 99%
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“…There are examples of histidine kinase-related proteins in Bacillus subtilis (Yang et al 1996) and the eukaryotic mitochondrion (Popov et al 1992) that mediate phosphoserine formation. In addition, there have been reports of Ser/Thr or Tyr autophosphorylating proteins in bacteria (Ostrovsky and Maloy 1995;Grangeasse et al 1997).Recently, genes encoding proteins homologous to eukaryotic Ser/Thr protein kinases have been identified in several bacteria (Kennelly and Potts 1996) and archaea (Smith and King 1995). Myxococcus xanthus encodes numerous paralogous Ser/Thr kinases that show highly significant sequence similarity to one another (Munoz-Dorado et al 1993).…”
mentioning
confidence: 99%
“…Recently, genes encoding proteins homologous to eukaryotic Ser/Thr protein kinases have been identified in several bacteria (Kennelly and Potts 1996) and archaea (Smith and King 1995). Myxococcus xanthus encodes numerous paralogous Ser/Thr kinases that show highly significant sequence similarity to one another (Munoz-Dorado et al 1993).…”
mentioning
confidence: 99%
“…An important part of this homeostatic control system are the bacterial two-component regulatory systems, and the genome of the cyanobacterium Synechocystis PCC 6803 has an abundance of genes encoding such systems (1). During the past years, it has become increasingly evident that in addition to this signaling mode, protein O-phosphorylation, previously thought to be only important in eukaryotic signal transduction, occurs in various groups of Gram-negative and Gram-positive bacteria (2,3) and is particularly widespread in cyanobacteria (4). Surveys of the 3.6-Mbp genome of Synechocystis PCC 6803 revealed more than 20 putative serine͞threonine and tyrosine-specific protein kinases (PK) and protein phosphatases (PP) (4,5).…”
mentioning
confidence: 99%
“…once thought to be unique to eukaryotes are now an established integral component of many prokaryotic genomes (1)(2)(3)(4)(5). The coordinated action of STPKs with a cohort of protein modules leads to the formation of numerous signaling cascades essential for cell survival.…”
mentioning
confidence: 99%