Far-infrared rays control prostate cancer cells in vitro and in vivo

Abstract

We introduce a new effective method to control hormone refractory prostate cancer cells by using an activated rubber/resin form (RB), far-infrared ray emitter, with or without sodium butyrate (SB). The growth of three human prostate cancer cell lines (Du145, PC-3 and LNCaP) was suppressed in vitro and in vivo by using RB, and the cells were eradicated with RB + 3 mM SB. G1 arrest and apoptotic pathway proteins were induced by RB with intensified expressions of apoptosis - related mRNA on cDNA microarray. RB radiates the infra-red rays of the 4 to 25 [mu]m wavelengths to an object which exert a favorable influence on a cancer control. These results may render us a new therapeutic modality in hormone refractory prostate cancer.

Far-Infrared Irradiation Inhibits Adipogenic Differentiation and Stimulates Osteogenic Differentiation of Human Tonsil-Derived Mesenchymal Stem Cells: Role of Protein Phosphatase 2B

“…Previous studies have shown that FIR irradiation has therapeutic effects in various disease models, including models of cardiovascular disease and cancer [30,31]. For the last decade, several types of cells, including EC and cancer cells [21,22], have Fig.…”

Suppression of prostate cancer cell growth by mid-infrared rays

“…In the previous report 1 , it was pointed out that the effects of far-infrared rays in the range of 4 to 25 µm are due to the structural characteristics of RB, but the suppression of prostate cancer cell growth is not due to the structural characteristics of RB. It is presumed that there is a difference in the heat distribution (mid-infrared around 4.8 µm) of cancer cells due to the function of the culture dish (polystyrene) as a lter.…”

“…Since heat (energy) is transmitted (radiated) as electromagnetic waves, when RB is used, it is thought that the re ectance of electromagnetic waves by RB and the electromagnetic wave transmittance of the culture dish (polystyrene) are related. The re ectance of RB has already been measured 1 . The transmittance of the culture dish was as shown in FIG.…”

“…This paper is based on paper 1 by the late Dr. Hiroki Shima and his own experiments, research, and considerations after submitting his thesis. In addition he developed an experimental device for cancer treatment and con rmed that mid-infrared rays were generated using a near-infrared camera (3.5-6 µm).…”

“…In a culture experiment of prostate cancer cells in which RB was placed above and below the culture dish, it was reported that the apoptotic pathway of the prostate cancer cells was activated, leading to inhibition of proliferation and death of the prostate cancer cells 1 .When human prostate cancer cells (DU145, PC-3 and LNCaP) were cultured with the temperature in the incubator set at 37°C, the temperature of the culture medium without RB was 37.32°C and the temperature of the culture medium with RB was 37.68°C. The temperature difference of 0.36°C was con rmed 1 .…”