2012
DOI: 10.1021/jz301440c
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Far/Mid-Infrared Signatures of Solvent–Solute Interactions in a Microhydrated Model Peptide Chain

Abstract: Far/mid-IR signatures of the first hydration step of a flexible biomolecule, the model peptide chain Ac-Phe-NH2, have been investigated in the gas phase using the selective IR/UV double-resonance laser technique. The broad spectral region investigated with the free-electron laser FELIX (150–800 cm–1/70–12 μm) provided a direct access to three intermolecular vibrational modes of monohydrates, in which the water molecule bridges neighboring NH and CO sites of the peptide backbone. The spectral features, analyzed… Show more

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Cited by 26 publications
(44 citation statements)
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“…The far-IR region (wavelength >20 μm) remains the least explored so far [51,66,69,117]. IR/UV double resonance experiments have been carried out successfully in this range, illustrating the feasibility of the technique in the 150-700 cm À1 low frequency range at a FEL facility (Fig.…”
Section: Methodsmentioning
confidence: 87%
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“…The far-IR region (wavelength >20 μm) remains the least explored so far [51,66,69,117]. IR/UV double resonance experiments have been carried out successfully in this range, illustrating the feasibility of the technique in the 150-700 cm À1 low frequency range at a FEL facility (Fig.…”
Section: Methodsmentioning
confidence: 87%
“…1a). Clear specific signatures of the water libration motions in peptide hydrates, together with specific out-ofamide-plane NH bends for the monomer, have been obtained [51]. Inclusion of vibrational couplings in the theoretical treatment has recently enabled a successful comparison between theory and experiment [117], which should foster further developments in the far-IR.…”
Section: Methodsmentioning
confidence: 96%
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“…Such studies are particularly important for gaining insight into the relations between the properties of biomolecules and their structures. The method demonstrated is highly suitable for this research field, since it enables the study of molecular associates, such as microhydrated molecules [34], and one can selectively study the intrinsic properties of biomolecules associated with intramolecular interactions as well as those associated with interactions and perturbations induced by the ambient environment (intermolecular interactions). We believe that the technique presented in this work will significantly advance the field of molecular structure characterization.…”
mentioning
confidence: 99%