This work is an application of experimental temperature data previously collected in a residential building in Douala, Cameroon, in order to analyze thermal discomfort. The data was collected according to three occupancy scenarios over 12 month period using thermohygrometer sensors. The temperature data are analysed in comparison with the comfortable temperature range from 24°C to 28°C. The degree hour (DH) method was used to assess the severity of thermal discomfort in a hot and humid climate. The results reveal that the open C1, closed C2 and inhabited C3 rooms corresponding to scenarios C1, C2 and C3 respectively, have 7270.6°H, 9063.9°H and 10023°H. The inhabited room C3 has the largest DH and although the room C1 has the smallest DH, the latter largely exceeded the tolerable limit value of 1250°H set by the RE2020 Environmental Regulations. Results from this work can serve in building modelling for researchers and architects to act for the alleviation of thermal discomfort in regions with hot and humid climate.