FARKLI NERGİS KÜLTÜR ÇEŞİTLERİ SOĞANLARININ IN VITRO ANTİOKSİDAN, ASETİLKOLİNESTERAZ ve BÜTİRİLKOLİNESTERAZ AKTİVİTELERİ

Poyraz, İlham Eröz; Kıyan, Hülya Tuba; Zeybekoǧlu, Emrah; Özzambak, Mustafa Ercan; Öztürk, Nilgün

doi:10.18036/estubtdc.574441

Cited by 1 publication

(4 citation statements)

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“…Inhibition of AChE and BuChE is the target in the effective treatment of AD by reducing β-amyloid accumulation in the brain and increasing acetylcholine utilization . AChE inhibitory effect and BuChE inhibitory effect studies were carried out to investigate the potential of the A-FA coded optimum formulation prepared within the scope of this thesis to be used in AD.…”

Section: Resultsmentioning

confidence: 99%

“…The damage caused by free radicals caused by oxidative stress to neurons and metal accumulation in the brain is directly related to the pathogenesis of Alzheimer’s. It is important in the treatment that a therapeutic agent used against Alzheimer’s has both AChE inhibitor and antioxidant properties …”

Section: Resultsmentioning

confidence: 99%

“…Inhibition of AChE and BuChE is the target in the effective treatment of AD by reducing β-amyloid accumulation in the brain and increasing acetylcholine utilization. 83 AChE inhibitory effect and BuChE inhibitory effect studies were carried out to investigate the potential of the A-FA coded optimum formulation prepared within the scope of this thesis to be used in AD. In the AChE inhibitor effect study, the IC 50 value of the A-FA coded formulation loaded with FA was obtained as 121.65 μg·mL –1 , and in the BuChE inhibitor effect study, the IC 50 value was found to be 419.46 μg·mL –1 .…”

Section: Resultsmentioning

confidence: 99%

“…It is important in the treatment that a therapeutic agent used against Alzheimer’s has both AChE inhibitor and antioxidant properties. 83 …”

Section: Resultsmentioning

confidence: 99%

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Preparation, Characterization, Antioxidant Activities, and Determination of Anti-Alzheimer Effects of PLGA-Based DDSs Containing Ferulic Acid

Arınmış,

Kıyan,

Öztürk

2024

ACS Omega

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Nanoparticle (NP) systems have attracted the attention of researchers in recent years due to their advantages, such as modified release features, increased therapeutic efficacy, and reduced side effects. Ferulic acid (FA) has therapeutic effects such as anti-inflammatory, anti-Alzheimer's, antioxidant, antimicrobial, anticancer, antihyperlipidemic, and antidiabetic. In this study, FA-loaded PLGA-based NPs were prepared by a nanoprecipitation method and the effect of varying concentrations of Poloxamer 188 and Span 60 on NP properties was investigated. FA-loaded A-FA coded formulation was chosen as optimum. High encapsulation efficiency has been achieved due to the low affinity of FA to the water phase and, therefore, its lipophilic nature, which tends to migrate to the organic phase. It was determined that the release of FA from the A-FA was slower than pure FA and prolonged release in 24 h. Antioxidant and anti-Alzheimer's effects of A-FA coded NP formulation were investigated by biological activity studies. A-FA coded NP formulation showed strong DPPH free radical scavenging, ABTS cation decolorizing, and reducing antioxidant activity. Since it has both AChE inhibitor and antioxidant properties according to the results of its anti-Alzheimer activity, it was concluded that the formulation prepared in this study shows promise in the treatment of both oxidative stress-related diseases and Alzheimer's.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…It is important in the treatment that a therapeutic agent used against Alzheimer’s has both AChE inhibitor and antioxidant properties. 83 …”

Section: Resultsmentioning

confidence: 99%

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