Farm‐derived <scp>G</scp>ram‐positive bacterium <i><scp>S</scp>taphylococcus sciuri </i><scp>W</scp>620 prevents asthma phenotype in <scp>HDM</scp>‐ and <scp>OVA</scp>‐exposed mice

Hagner, Stefanie; Harb, Hani; Zhao, Min; Stein, Karina; Holst, Otto; Ege, Markus; Mayer, Melanie; Matthes, Jakob; Bauer, Johann; Mutius, Erika von; Renz, H.; Heine, Holger; Pfefferle, Petra Ina; Garn, Holger

doi:10.1111/all.12094

Cited by 75 publications

(60 citation statements)

References 18 publications

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“…In both studies, the diversity of microorganisms found was inversely related to the risk of asthma (48). Some of the microorganisms found in dust collected from protective farms have been shown to exert potent antiallergic effects in animal models (82)(83)(84) (47). Similarly, a genetically homogeneous population living in Karelia is partitioned between Finland and Russia.…”

Section: Natural Environment and Immunoregulationmentioning

confidence: 99%

Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health

Rook

2013

Proc. Natl. Acad. Sci. U.S.A.

613

456

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Epidemiological studies suggest that living close to the natural environment is associated with long-term health benefits including reduced death rates, reduced cardiovascular disease, and reduced psychiatric problems. This is often attributed to psychological mechanisms, boosted by exercise, social interactions, and sunlight. Compared with urban environments, exposure to green spaces does indeed trigger rapid psychological, physiological, and endocrinological effects. However, there is little evidence that these rapid transient effects cause long-term health benefits or even that they are a specific property of natural environments. Meanwhile, the illnesses that are increasing in high-income countries are associated with failing immunoregulation and poorly regulated inflammatory responses, manifested as chronically raised C-reactive protein and proinflammatory cytokines. This failure of immunoregulation is partly attributable to a lack of exposure to organisms (“Old Friends”) from mankind’s evolutionary past that needed to be tolerated and therefore evolved roles in driving immunoregulatory mechanisms. Some Old Friends (such as helminths and infections picked up at birth that established carrier states) are almost eliminated from the urban environment. This increases our dependence on Old Friends derived from our mothers, other people, animals, and the environment. It is suggested that the requirement for microbial input from the environment to drive immunoregulation is a major component of the beneficial effect of green space, and a neglected ecosystem service that is essential for our well-being. This insight will allow green spaces to be designed to optimize health benefits and will provide impetus from health systems for the preservation of ecosystem biodiversity.

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Section: Natural Environment and Immunoregulationmentioning

confidence: 99%

Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health

Rook

2013

Proc. Natl. Acad. Sci. U.S.A.

613

456

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“…Nos artigos selecionados observou-se que o modelo agudo foi usado em dez artigos. Os resultados mostram, em relação ao desfecho inflamatório no pulmão, que os grupos expostos ao HDM apresentam percentual elevado de eosinófilos, alto número de células nas contagens total, inflamação das vias aéreas, produção de células caliciformes, hiper-responsividade das vias aéreas, IgE total no soro, aumento de citocinas IL-4 e IL-5 e alto influxo celular na área peribronquial e perivascular 14,16,18,19,21,23,[24][25][26]29 . Em relação à função pulmonar, o trabalho de Phipps et al 26 mostra um aumento da resistência e diminuição da complacência das vias aéreas.…”

Section: Johnson Et Al (2008) 27unclassified

“…Portanto, depreende-se que o modelo agudo de exposição ao HDM é um método importante para avaliar e obter resultados preliminares e sem uso de adjuvante. Os desfechos inflamatórios no tecido pulmonar são baseados em eosinófilos 16,19,24,25 . Por outro lado, modelos crônicos de exposição ao alérgeno assemelham-se ao modelo agudo 10 .…”

Section: Johnson Et Al (2008) 27unclassified

“…Observa-se na Tabela 1 que a dose mais usada foi de 100µg. Os resultados desses trabalhos mostram que o número de células totais e diferenciais no lavado broncoalveolar (BAL) é significativamente alto, assim como a inflamação das vias aéreas e a produção de células caliciformes 16,19,23,29 . A contagem total e diferencial das células, o nível de IgE no soro e a resistência das vias aéreas à metacolina também são elevadas.…”

Section: Johnson Et Al (2008) 27unclassified

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Revisão Sistemática Sobre Modelos Experimentais De Asma Aguda E Crônica Induzidos Com Extrato De Ácaro Da Poeira Doméstica

et al. 2017

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“…Epidemiologic studies have shown that the development of asthma [7][8][9] and chronic obstructive pulmonary disease 10,11 is related to the diversity of colonizing organisms in the nasal flora. In mice, lack of microbial colonization increases allergic airway inflammation, 12,13 and colonization with multiple species protects against airway inflammation.…”

Section: Nasopharyngeal Commensal Speciesmentioning

confidence: 99%

The new first-line defense: the potential of nasopharyngeal colonization in vaccine strategies

Chan¹,

Cohen²,

Brown³

2016

VDT

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Abstract:Pathogens that can colonize the upper respiratory tract include Streptococcus pneumoniae, Hemophilus influenzae, Neisseria meningitidis, Moraxella catarrhalis, and Staphylococcus aureus. While these pathogens commonly asymptomatically colonize the nasopharynx of healthy adults, disease progression may occur in some individuals. In addition to these respiratory pathogens, there are a large number of commensal species also found in the upper respiratory tract which only very rarely cause disease, creating a complex community of bacterial species in the nasopharynx. This review addresses the novel, potential strategies that utilize the interactions between both homologous and heterologous species in the nasopharynx to vaccinate individuals against pathogenic bacteria. These strategies include the mechanisms employed by colonizing bacteria to regulate the presence of other species in the nasopharynx and the effect that colonization of the nasopharynx has on the host immune response. Interventional strategies investigated so far include the introduction of nonpathogenic bacteria to the nasopharynx to immunize against a closely related species, controlled colonization using both wild-type and attenuated species, and the use of other nonpathogenic colonizers to express antigens from potential pathogens. All these approaches harness the ability of the colonization to induce a mucosal immune response that can protect against future infection. In this review, S. pneumoniae and N. meningitidis colonization are used as case studies for this approach as the immunological effects of colonization have been widely studied in animal and human models. Colonization-based strategies have great potential, and, in particular, the attenuated strain approach has produced some encouraging data in animal models. However, the strategy for attenuating virulence must be stringent and caused by highly stable mutations that are unlikely to revert. In addition, the consequences of artificial administration of genetically modified bacteria to the nasopharynx on the usual host microbiome are unknown and would need to be monitored carefully.

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Farm‐derived Gram‐positive bacterium Staphylococcus sciuri W620 prevents asthma phenotype in HDM‐ and OVA‐exposed mice

Cited by 75 publications

References 18 publications

Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health

Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health

Revisão Sistemática Sobre Modelos Experimentais De Asma Aguda E Crônica Induzidos Com Extrato De Ácaro Da Poeira Doméstica

The new first-line defense: the potential of nasopharyngeal colonization in vaccine strategies

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