Farm exposure and time trends in early childhood may influence <scp>DNA</scp> methylation in genes related to asthma and allergy

Michel, Sven; Busato, Florence; Genuneit, Jon; Pekkanen, Juha; Dalphin, Jean‐Charles; Riedler, Josef; Mazaleyrat, Nicolas; Weber, Juliane; Karvonen, Anne M.; Hirvonen, Maija; Braun‐Fahrländer, Charlotte; Lauener, Roger; Mutius, Erika von; Kabesch, Michael; Tost, Jörg

doi:10.1111/all.12097

Cited by 145 publications

(109 citation statements)

References 47 publications

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“…DNA methylation patterns observed in cord blood, which were not found at 4 y of age in a large rural birth cohort, showed hypermethylation in loci related to ORMDL3, and also signal transducer and activator of transcription 6 (STAT6), in asthmatics from nonfarm environments as compared with nonasthmatic farm children (74). This suggests that epigenetic influences present at birth, but not after 4 y of age, may influence disease susceptibility.…”

Section: Environmental Influence and Genetic Susceptibilitymentioning

confidence: 89%

“…This suggests that epigenetic influences present at birth, but not after 4 y of age, may influence disease susceptibility. Interestingly, the asthmatic farmers' children had a significant decrease in methylation of the ORMDL3 loci over time as compared with increasing methylation in asthmatic children of nonfarmers, suggesting an environmental effect on epigenetic changes in the 17q21 locus (74).…”

Section: Environmental Influence and Genetic Susceptibilitymentioning

confidence: 97%

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17q21 locus and ORMDL3: an increased risk for childhood asthma

Ono

Worgall

2013

Pediatr Res

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Section: Environmental Influence and Genetic Susceptibilitymentioning

confidence: 89%

Section: Environmental Influence and Genetic Susceptibilitymentioning

confidence: 97%

17q21 locus and ORMDL3: an increased risk for childhood asthma

Ono

Worgall

2013

Pediatr Res

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“…Demethylation of the FOXP3 promoter was found in an extensive farming exposure environment [13]. Farm childhood also had hypomethylation of ORMDL1 and STAT6 and hypermethylation of RAD and IL-13 [14]. DNA methylation in the CD14 promoter was also significantly less in farm mothers [15].…”

Section: The Genomic Approach Methodologiesmentioning

confidence: 94%

Untitled

2016

JIG

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Common respiratory diseases including asthma, chronic obstructive pulmonary disease (COPD) and lung cancer are increasing worldwide. Genomic approaches for the diseases provided new insights of the mechanisms and revealed the new therapeutic targets. Genome-wide association studies (GWAS), epigenetic studies, transcriptional profiling, RNA sequencing, chromatin immune precipitation (ChIP) sequencing and microbiota investigation make personalized medicine for common respiratory diseases possible in the near future. In this review, we summarize the current progress of genomic approaches for asthma, COPD and lung cancer and also discuss the future directions of the research of the diseases.

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“…Data from two independent pregnancy cohorts in Spain (discovery and validation) showed that DNA hypomethylation in Alox12 in peripheral blood of children was associated with a higher risk of persistent wheezing at age 4 years [62]. Finally, DNA from cord blood and whole blood collected at 4.5 years of age with 46 samples per time point in the rural birth cohort PASTURE showed changes in methylation over time in 15/23 CpG regions near 10 asthma and atopy candidate genes [66]. In aggregate, these studies suggest that DNA methylation in easily obtained samples (buccal, nasal or peripheral blood cells) may be a useful biomarker for airway inflammation in paediatric research.…”

Section: Dna Methylation and Asthma: Human Studiesmentioning

confidence: 95%

Epigenetics and prenatal influences on asthma and allergic airways disease

Yang

2014

Breathe

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Epigenetics and prenatal influences on asthma and allergic airways disease IntroductionAsthma is a complex, heritable disease that has been increasing in prevalence, incidence and severity [1], although recent evidence suggests that the prevalence of asthma and allergies may have come to a plateau in developed countries [2]. Several separate lines of evidence support a role for epigenetics in asthma. First, asthma, like epigenetic mechanisms, is heritable. While asthma is a strongly familial condition (36-79% heritability) with a non-Mendelian pattern of inheritance and polymorphisms in more than 100 genes [3-6], these associations have infrequently been replicated and genetics has explained only a small portion of the aetiology of this disease [4]. Second, asthma, like epigenetic mechanisms, shows a parentof-origin transmission of inheritance with an affected mother significantly more likely to transmit the disease than an affected father [7]. These parent-of-origin effects may result from immune interactions between the fetus and the mother [8]. Alternatively, the maternal effect may be the result of epigenetically regulated genomic imprinting [9]. Several known genes show parent-of-origin effects on allergic disease; these genes include the FceRI-b locus [10], and the Spink5 gene [11]. Third, asthma, like epigenetic mechanisms [12,13], is affected by in utero exposures HERMES syllabus link: modules A.1, B.6 Statement of InterestNone declared.

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Farm exposure and time trends in early childhood may influence DNA methylation in genes related to asthma and allergy

Abstract: In this first pilot study, DNA methylation patterns change significantly in early childhood in specific asthma- and allergy-related genes in peripheral blood cells, and early exposure to farm environment seems to influence methylation patterns in distinct genes.

Cited by 145 publications

References 47 publications

17q21 locus and ORMDL3: an increased risk for childhood asthma

17q21 locus and ORMDL3: an increased risk for childhood asthma

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Epigenetics and prenatal influences on asthma and allergic airways disease

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