Despite the stigma surrounding cannabis, discourse has evolved, and it is now recognised as a viable economic commodity, reflecting a substantial transformation in societal attitudes. Several African countries have been exploring the industrial possibilities of medicinal hemp as a facet of economic development. This study aimed to examine the potential advantages of cannabis commercialisation in Limpopo province, South Africa. The study utilised a descriptive design and qualitative technique, focussing on cannabis enterprises. Snowball sampling was utilised to acquire a sample of 20 individuals. The sample size was determined by data saturation. Data was gathered through semi-structured interviews and thematically analysed using ATLAS.ti 23 software. The results indicate that the creation of cannabis cultivation and processing businesses may produce job opportunities, stimulate economic expansion, and promote community development. Furthermore, the cannabis industry presents substantial income generation prospects, especially for rural agriculturists, and has the capacity to augment tax revenue for local authorities. The research indicates that cannabis commercialisation could yield advantageous socio-economic results, such as poverty reduction, provided that stringent regulations and extensive community engagement are established. The research emphasises the importance of addressing legal and social equity challenges to ensure the sustainability of these benefits.