Farmacocinética de medicamentos de uso pediátrico, visión actual

Abstract

Pediatric drugs pharmacokinetics Pharmacokinetics corresponds to the branch of pharmacology that studies the absorption, distribution, biotransformation and excretion of drugs in the body, in order to proportionate a reference line for interpretation of drug concentration in biological fluids, fundamental for clinical therapy. While adult pharmacology has increase greatly, advances in pediatric pharmacology have been poor. Therefore, drug prescription in children is essentially empirical on the basis of an inmature organism. An effective, secure and rational pediatric pharmacology requires exhaustive knowledgement of the developmental changes in relation to absorption, distribution, metabolism and excretion affecting pharmacokinetics parameters; therefore, the effective dose. This review describes fundamental differences between adult and pediatric pharmacokinetics. These differences must be considered when therapeutic strategies develop for newborns and children.

Características de las interacciones farmacológicas en una unidad de cuidados intensivos de pediatría

“…Del total de la muestra estudiada, 44% de los pacientes presentaron IF en sus prescripciones médicas, corroborando reportes previos [7][8][9][10][11][12] . Un estudio nacional en UCI adulto reporta un total de 76 IF en 35 pacientes, aunque sólo buscó IF entre los sedantes-analgésicos y antibióticos y en pacientes con más de 3 días de hospitalización 14 .…”

“…Una terapéutica farmacológica efectiva, segura y racional en neonatos, lactantes y niños requiere del exhaustivo conocimiento de las diferencias en la absorción, distribución, metabolismo y excreción, las que van variando durante el crecimiento. Por desgracia, la FV en la UCI Pediátrica (UCIP) es un tema que aún está en desarrollo 6,7,9 . Son escasos los estudios cuantitativos que demuestran la magnitud de las IF en las UCI 10 11,12 .…”

Pharmacist care activities: a bibliometric analysis

“…Such characteristics lead these patients to require continuous follow‐up in order to guarantee the effectiveness and safety of their pharmacological treatment . The results of this bibliometric analysis emphasise the need for further studies in the paediatric population, which may be considered a priority because of the inherent risks of the use of medicines in children given their particular physiological characteristics …”

“…[32][33][34][35] The results of this bibliometric analysis emphasise the need for further studies in the paediatric population, which may be considered a priority because of the inherent risks of the use of medicines in children given their particular physiological characteristics. [36][37][38] The number of original papers included in each SR/ MA was highly variable. The SR/MAs on PCAs in ambulatory settings included a larger number of original studies.…”

Development, Physical-Chemical Stability, and Release Studies of Four Alcohol-Free Spironolactone Suspensions for Use in Pediatrics

“…From birth to adulthood, a series of anatomical, physiological, and biochemical modifications are produced that affect the absorption, distribution, metabolism, and excretion of drugs and their mechanisms of action, as well as enzyme synthesis and the production and distribution of receptors (11,12). Thus, drug prescribing must be based on knowledge of pharmacokinetic and pharmacodynamic characteristics (13).…”