Farmacocinética do propofol em nanoemulsão em gatos

Gehrcke, Martielo Ivan; Luiz, Rafael Messias; Lima, Marcos Paulo Antunes de; Farias, Felipe Hertzing; Poli, Anicleto; Moraes, Aury Nunes de; Oleskovicz, Nilson

doi:10.1590/s0103-84782013000400026

Cited by 3 publications

(5 citation statements)

References 11 publications

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“…In this respect, indirect calorimetry is a non-invasive method that provides data on a patient's metabolic state, such as oxygen consumption, carbon dioxide production, energy expenditure, and respiratory quotient. This information can be used to estimate cardiac output, which is invaluable for early detection of complications such as hypooxygenation and tissue hypoperfusion (Gehrcke & Oleskovicz, 2017).…”

Section: Introductionmentioning

confidence: 99%

Efeitos hemodinâmicos e respiratórios em ovinos submetidos a quatro modalidades de ventilação e anestesiados com isoflurano ou propofol

Rosa,

De Souza,

Regalin

et al. 2024

Sem. Ci. Agr.

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O objetivo deste estudo foi avaliar diferentes modalidades ventilatórias em ovinos anestesiados com isoflurano ou propofol. Foram utilizadas 12 ovelhas, adultas, mestiças, com 12 meses de idade, pesando 32±5 kg, comprovadamente hígidas. Após instrumentação com os animais conscientes em decúbito lateral direito, foi administrado morfina (0,3 mg kg-1) e detomidina (20 mcg kg-1) como MPA. Foram induzidas à anestesia geral com propofol (4 mg kg-1) e intubadas. Neste momento, foram alocadas em dois grupos: PG (n=6), manutenção com infusão contínua de propofol (0,5 mg kg min-1), e IG (n=6) com anestesia inalatória com isoflurano (1,3 V%). Todas foram mantidas por 30 minutos em cada modalidade ventilatória: ventilação espontânea (VE), ventilação mecânica ciclada a volume (VV), ventilação mecânica ciclada a pressão (VP) e ventilação mecânica ciclada a pressão com PEEP (VPP). A FC e o IC foram maiores em IG e já o IRVS foi maior em PG. Os valores de hemoglobina, fração de shunt intrapulmonar e o volume corrente foram maiores no PG. Os animais apresentaram alcalose metabólica em ambos os grupos. O isoflurano promoveu maior hipotensão, diminuição da complacência pulmonar, aumento da resistência das vias aéreas, menores valores de PaO2 e maiores valores de PaCO2 em todas as modalidades ventilatórias. A VPP promoveu maior complacência pulmonar e índice de oxigenação, maiores valores de PaO2 e menores valores de shunt intrapulmonar. Conclui-se que o propofol e a VPP promoveram maior estabilidade hemodinâmica em ovelhas.

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Section: Introductionmentioning

confidence: 99%

Efeitos hemodinâmicos e respiratórios em ovinos submetidos a quatro modalidades de ventilação e anestesiados com isoflurano ou propofol

Rosa,

De Souza,

Regalin

et al. 2024

Sem. Ci. Agr.

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“…Hence, TIVA in this species using propofol as the sole anesthetic agent should be avoided, 8 in order to prevent cumulative effects and delayed recovery. 8,9…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7] However, cats slowly metabolize phenolic compounds owing to the lack of functional glucuronosyltransferase (UGT1A6) enzymes. Hence, TIVA in this species using propofol as the sole anesthetic agent should be avoided, 8 in order to prevent cumulative effects and delayed recovery. 8,9 Anesthetic adjuvants are used to minimize the impact of propofol TIVA in cats.…”

Section: Introductionmentioning

confidence: 99%

“…Hence, TIVA in this species using propofol as the sole anesthetic agent should be avoided, 8 in order to prevent cumulative effects and delayed recovery. 8,9 Anesthetic adjuvants are used to minimize the impact of propofol TIVA in cats. Fentanyl and its congeners have been shown to reduce the propofol dose required to maintain anesthesia, while also providing better intraoperative analgesia and cardiorespiratory stability, and shorter recovery times.…”

Section: Introductionmentioning

confidence: 99%

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Cardiopulmonary and propofol-sparing effects of dexmedetomidine in total intravenous anesthesia in cats undergoing ovariohysterectomy

Sanches

Bessi

Rusch

et al. 2022

Journal of Feline Medicine and Surgery

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Objectives This study aimed to assess the effect of dexmedetomidine on the propofol-based anesthesia of cats subjected to ovariohysterectomy. Methods Twenty-eight cats were randomly allocated to four groups (seven cats in each) and premedicated with either 5 µg/kg dexmedetomidine (groups Dex 1, Dex 3 and Dex 5) or 0.05 ml saline (Prop group) intramuscularly. After the induction of anesthesia with propofol, total intravenous anesthesia was initiated with 300 µg/kg/min propofol plus 3 ml/kg/h NaCl 0.9% (Prop), or 200 µg/kg/min propofol plus dexmedetomidine at the rates of 1 µg/kg/h (Dex 1), 3 µg/kg/h (Dex 3) or 5 µg/kg/h (Dex 5). Cardiorespiratory variables were assessed 5 mins after induction and every 10 mins thereafter, until the end of anesthesia. The propofol infusion rate was adjusted every 10 mins (± 50 µg/kg/min) to maintain anesthetic depth. The times to extubation, sternal recumbency, ambulation and total recovery were recorded. Pain scoring was performed 1, 2, 4, 8, 12 and 24 h after the end of anesthesia. Results Dexmedetomidine produced a propofol-sparing effect of 72.8%, 71.1% and 74.6% in the Dex 1, Dex 3 and Dex 5 groups, respectively. Cats in the Prop group maintained higher heart rate values than the other groups, and the mean arterial pressure remained higher in the Dex 3 and Dex 5 groups. Rescue intraoperative analgesia (fentanyl bolus) was most frequent in the Prop group. There was no significant difference in the time of extubation. Cats in the Dex 1 and Dex 3 groups had a faster anesthetic recovery, with shorter times to achieving sternal recumbency, regaining ambulation and reaching full recovery. Cats in the Dex 1 and Dex 5 groups presented the best recovery quality scores, with 4 (range 4–5) and 4 (range 3–5), respectively, while the Prop group scored 1 (range 1–3), the worst anesthetic recovery score among the groups. Conclusions and relevance The use of dexmedetomidine as a total intravenous anesthesia adjuvant, especially at doses of 1 and 3 µg/kg/h, reduces propofol consumption and improves cardiorespiratory stability and intraoperative analgesia, while promoting a better and quicker recovery from anesthesia.

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“…Os efeitos hemodinâmicos resultam da ativação dos receptores α 2 présinápticos das terminações nervosas periféricas, e efeitos sobre o tronco cerebral e a medula espinhal (LAVAND'HOMME et al, 2008 BERNARDI, 2002b;GEHRCKE et al, 2013).…”

Section: Introductionunclassified

Efeito da raquianestesia com bupivacaína associada ou não à clonidina em gatas submetidas a ovariosalpingohisterectomia

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Farmacocinética do propofol em nanoemulsão em gatos

Cited by 3 publications

References 11 publications

Efeitos hemodinâmicos e respiratórios em ovinos submetidos a quatro modalidades de ventilação e anestesiados com isoflurano ou propofol

Efeitos hemodinâmicos e respiratórios em ovinos submetidos a quatro modalidades de ventilação e anestesiados com isoflurano ou propofol

Cardiopulmonary and propofol-sparing effects of dexmedetomidine in total intravenous anesthesia in cats undergoing ovariohysterectomy

Efeito da raquianestesia com bupivacaína associada ou não à clonidina em gatas submetidas a ovariosalpingohisterectomia

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