Farmacogenética I. Concepto, historia, objetivos y áreas de estudio

La medicina personalizada: ¿metaverso o realidad?

“…Es por ello que pensáramos que con la aplicación de la farmacogenética en la práctica clínica habitual se consiguiese emplear la información genotípica del paciente para seleccionar el tratamiento más adecuado, realizar un buen ajuste de la dosis y/o prevenir la aparición de reacciones adversas (5), reduciendo el riesgo para los pacientes y disminuyendo el periodo de tiempo que se tarda en seleccionar el fármaco adecuado y la dosis eficaz. La medicina personalizada reconoce que cada paciente es único y que no existe una respuesta uniforme al tratamiento.…”

Genetic Polymorphisms Associated With the Pharmacokinetics, Pharmacodynamics and Adverse Effects of Olanzapine, Aripiprazole and Risperidone

“…Pharmacogenetics studies the influence of genetic variability on drug response. Its aim is to select "the right drug, at the right dose, for the right patient," predicting the tolerance and effectiveness of the drug in each patient, considering the individual's genetic information ( Daudén Tello, 2006 ). To date, two of the most important groups that develop pharmacogenetic guidelines are the Clinical Pharmacogenetics Implementation Consortium (CPIC) ( Caudle et al, 2014 ) and the Dutch Pharmacogenetics Working Group (DPWG) ( Bank et al, 2018 ).…”

Has the Human Genome Project Delivered for Healthcare?

“…It was predicted that the HGP would eventually reward clinical medicine with novel approaches to treatment. Pharmacogenomics is the concept that drugs can be tailored to an individual's genetic make-up to increase their efficacy and safety; 16 for example by identifying how cytochrome P450 variants metabolise drugs differently. 17 Patients could also benefit from speedier recoveries without having to pursue different treatment regimens before the best is discovered.…”