Farmanol: A New Dammarane Methoxytriterpenediol from Nepeta suavis

Khan, Farman Ullah; Hussain, Hidayat; Khan, Ihsan Ullah; Muhammad, Nawshad; Badshah, Syed Lal; Aslam, Muhammad Waqar; Jan, Saleem; Khan, Rehmat Ali; Khan, Hizbullah

doi:10.14233/ajchem.2014.15344

Cited by 3 publications

(2 citation statements)

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“…The NH 2 hydrogens are involved in hydrogen bonding with oxygen of NO − 3 group which makes both the thiazole rings coplanar with negligible deviation with respect to each other. Intermolecular argentophilic 35,36 or S-S interactions 37 were not observed as it had already been reported for Ag and other related complexes.…”

Section: Structure Of Complexsupporting

confidence: 49%

Methyl-substituted 2-aminothiazole–based cobalt(II) and silver(I) complexes:synthesis, X-ray structures, and biological activities

Khan¹,

Ahmad²,

Gul³

et al. 2019

Turk J Chem

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2-Aminothiazole derivatives bear three nucleophilic centers, i.e. endocyclic N, exocyclic NH 2 , and S atom in the ring system. In addition to these centers there are π-electrons in the ring system which can also expectedly be involved in some sort of coordination. To the best of our knowledge the solid state coordination chemistry of such ligands has not been fully presented in the literature. These ligands (2-amino-4-methylthiazole and 2-amino-5-methylthiazole) were coupled with CoCl 2 under aerobic conditions to form tetrahedral complexes, bis(2-amino-4methylthiazole)dichlorocobalt(II) (1) and bis(2-amino-5-methylthiazole)dichlorocobalt(II) (2). Reaction of 2-amino-5-methylthiazole with AgNO 3 led to an expected two-coordinated, bis(2-amino-5-methylthiazole)silver(I) nitrate (3) as crystalline material. In all complexes the coordination behavior of the aminothiazole derivatives was identical, coordinating to the metal center through endocyclic N atom. The structures of these complexes were confirmed by single-crystal X-ray analysis. Compounds (1-3) were screened for their antimicrobial potency against gram-negative (E. sakazkii, E. coli, K. pneumoniae) and a gram-positive bacteria (S. aurus). Additionally, their role as enzyme inhibitors (acetylcholinesterase, AChE, and butyrylcholinesterase, BChE) and their free radical scavenging ability (2,2-Diphenyl-1-picrylhydrazyl, DPPH, and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid, ABTS) were studied. These ligands bear additional nucleophilic centers (S and NH 2) and can be involved in secondary interactions as confirmed by their solid-state structures. These interactions make the molecules biologically important and thus play a pivotal role in establishing the supramolecular network. We report here the coordination chemistry and selected biological applications of complexes 1-3.

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Section: Structure Of Complexsupporting

confidence: 49%

Methyl-substituted 2-aminothiazole–based cobalt(II) and silver(I) complexes:synthesis, X-ray structures, and biological activities

Khan¹,

Ahmad²,

Gul³

et al. 2019

Turk J Chem

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“…The compounds 1,3,4-oxadiazole heterocycles are good bioisosteres of amides and esters, which can contribute substantially in increasing pharmacological activity by participating in hydrogen bonding interactions with the receptors [3]. The 2,5-disubstituted-1,3,4-oxadiazole derivatives are known for various pharmacological activities such as antibacterial [4], anti-inflammatory [5], analgesic [6], antiviral and anticancer [7], antihypertensive [8], anticonvulsant [9], antiproliferative [10], herbicidal [11], hypoglycemic [12], hypnotic and sedative [13], MAO inhibitor [14] and insecticidal [15].…”

Section: Introductionmentioning

confidence: 99%

Thermo-physical properties of 1,3,4-oxadiazole derivatives in pure solvents

Godhani

Dobariya

Sanghani

et al. 2013

The Journal of Chemical Thermodynamics

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Triterpenoids

Hill

Connolly

2018

Nat. Prod. Rep.

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Covering 2014. Previous review: Nat. Prod. Rep., 2017, 34, 90-122This review covers the isolation and structure determination of triterpenoids reported during 2014 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, isomalabaricanes and saponins; 374 references are cited.

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Farmanol: A New Dammarane Methoxytriterpenediol from Nepeta suavis

Cited by 3 publications

References 0 publications

Methyl-substituted 2-aminothiazole–based cobalt(II) and silver(I) complexes:synthesis, X-ray structures, and biological activities

Methyl-substituted 2-aminothiazole–based cobalt(II) and silver(I) complexes:synthesis, X-ray structures, and biological activities

Thermo-physical properties of 1,3,4-oxadiazole derivatives in pure solvents

Triterpenoids

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