Background.Agrochemicals are used by farmers in Southeast Nigeria to increase crop yields and food production. However, farmers are often illiterate and do not follow precautions for their usage and application, increasing the risk of exposures to humans and the environment.Objectives.The aim of the present study was to determine the extent of the use of agrochemicals by farmers, category or type used, ability to read instructions, exposure to agrochemicals during application and perception of the health effects of exposure to agrochemicals in Southeast Nigeria.Methods.From February–June 2017, a total of 200 farmers were surveyed using oral interviews and structured questionnaires. Data were analyzed using descriptive statistics. Respondents were asked about items such as socioeconomic characteristics, types and amounts of fertilizers and pesticides used, exposure during application and perceptions of the health effects of exposure to agrochemicals.Results.In the present study, the majority of farmers (74%) used inorganic fertilizers (nitrogen, phosphorus, and potassium (NPK)) and 26% used organic fertilizers (compost manure). Most of the farmers in the present study (65%) reported that they could not read agrochemical application instructions, 92% of farmers were exposed to agrochemicals during application, and most farmers (73%) reported falling sick after exposure to agrochemicals.Conclusions.We recommend that agricultural extension agents provide farmers with comprehensive training in agrochemical use to ensure their health and lower environmental risks.Participant Consent.ObtainedEthics Approval.The study was approved by the Research Ethics Committee, Department of Agricultural Economics, Faculty of Agriculture, University of Nigeria, NsukkaCompeting Interests.The author declares no competing financial interests