Understanding the typology of smallholder maize farmers is crucial to elucidate the diversity in local farming systems, and therefore, devise effective interventions and policies that maximize the impact of agricultural innovations in South-Kivu province, eastern Democratic Republic of Congo (DRC). This study aimed at characterizing maize farmers in South-Kivu province and clustering them based on various socioeconomic and agronomic factors to identify specific production constraints and devise more effective interventions. A household survey among 300 South-Kivu maize farmers allowed to identify four distinct clusters based on farm size, land use, income, and agricultural technology adoption. The clusters ranged from resource-poor smallholder (Types 1 and 2) to medium-resource semi-innovative producers (Type 3) and highly equipped innovative farmers (Type 4). Key discriminative factors included total farm size, maize farm size, farming experience, access to agricultural credit, income, and innovation adoption rate. This study revealed specific constraints for each cluster, including low soil fertility, poor weed management, low market access, and labor scarcity. This study’s findings demonstrate the value of farm typology in guiding targeted interventions to address specific constraints and improve maize productivity, and suggest specific strategic directions for research and development projects in rural areas of the South-Kivu province.