Farnesol increases the susceptibility of <i>Burkholderia pseudomallei</i>
 biofilm to antimicrobials used to treat melioidosis

Castelo‐Branco, Débora Souza Collares Maia; Riello, Giovanna Barbosa; Vasconcelos, David Caldas; Guedes, Gláucia M.M.; Serpa, Rosana; Bandeira, Tereza J. P. G.; Monteiro, André Jalles; Cordeiro, Rossana de Aguiar; Rocha, Marcos Fábio Gadelha; Sidrim, José Júlio Costa; Brilhante, Raimunda Sâmia Nogueira

doi:10.1111/jam.13027

Cited by 38 publications

(10 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The COMSTAT analyses were used for quantitative analysis of the image stacks produced by CLSM (Heydorn et al 2000). The evaluated parameters obtained for the live biofilm cells included biofilm average coverage, average thickness, and biovolume, whereas thresholding was automatically calculated as previously described (Castelo-Branco et al 2016).…”

Section: Methodsmentioning

confidence: 99%

Butenolide, a Marine-Derived Broad-Spectrum Antibiofilm Agent Against Both Gram-Positive and Gram-Negative Pathogenic Bacteria

et al. 2019

View full text Add to dashboard Cite

Bacterial biofilm can cause nosocomial recurrent infections and implanted device secondary infections in patients and strongly promotes development of pathogenic drug resistance in clinical treatments. Butenolide is an effective anti-macrofouling compound derived from a marine Streptomyces sp., but its antibiofilm efficacy remains largely unexplored. In the present study, the antibiofilm activities of butenolide were examined using biofilms formed by both Gram-positive and Gram-negative pathogenic model species. Four Escherichia coli strains, Pseudomonas aeruginosa , and methicillin-resistant Staphylococcus aureus (MRSA) were used as targets in antibiofilm assays that examined the effects of butenolide, including the following: (i) on bacterial growth; (ii) in inhibiting biofilm formation and eradicating mature biofilm; (iii) on biofilm structures. In addition, the synergistic effect between butenolide with tetracycline was also examined. Butenolide not only effectively inhibited the biofilm formation but also eradicated pre-formed biofilms of tested bacteria. Fractional inhibitory concentration index (FICI) indicated that butenolide was a potential tetracycline enhancer against E. coli , P. aeruginosa , and MRSA. These results indicated that butenolide may hold a great potential as an effective antibiofilm agent to control and prevent biofilm-associated infections in future clinical treatments. Electronic supplementary material The online version of this article (10.1007/s10126-018-9861-1) contains supplementary material, which is available to authorized users.

show abstract

Section: Methodsmentioning

confidence: 99%

Butenolide, a Marine-Derived Broad-Spectrum Antibiofilm Agent Against Both Gram-Positive and Gram-Negative Pathogenic Bacteria

et al. 2019

View full text Add to dashboard Cite

show abstract

“…A recent study conducted by Castelo-Branco et al [75] showed potentiation effects of a combination therapy of farnesol with amoxicillin, doxycycline, ceftazidime, and sulfamethoxazole-trimethoprim against B. pseudomallei . A phenol sesquiterpene, xanthorrhizol was found to reduce 60% of Staphylococcus mutans cell adherence ability [76], and inhibited the growth of Mycobacterium smegmatis [77].…”

Section: Terpenes and Their Derivativesmentioning

confidence: 99%

Terpene Derivatives as a Potential Agent against Antimicrobial Resistance (AMR) Pathogens

et al. 2019

View full text Add to dashboard Cite

The evolution of antimicrobial resistance (AMR) in pathogens has prompted extensive research to find alternative therapeutics. Plants rich with natural secondary metabolites are one of the go-to reservoirs for discovery of potential resources to alleviate this problem. Terpenes and their derivatives comprising of hydrocarbons, are usually found in essential oils (EOs). They have been reported to have potent antimicrobial activity, exhibiting bacteriostatic and bactericidal effects against tested pathogens. This brief review discusses the activity of terpenes and derivatives against pathogenic bacteria, describing the potential of the activity against AMR followed by the possible mechanism exerted by each terpene class. Finally, ongoing research and possible improvisation to the usage of terpenes and terpenoids in therapeutic practice against AMR are discussed.

show abstract

“…Castelo-Branco et al (2012) showed a potent antimicrobial effect exerted by exogenous farnesol exposure against mature Burkholderia pseudomallei biofilms [ 90 ]. Additionally, it increased the activity of amoxicillin, ceftazidime, doxycycline, and sulfamethoxazole-trimethoprim, which are routinely administered for the treatment of melioidoses [ 91 ]. Farnesol also had a synergizing effect against ciprofloxacin-resistant Pseudomonas aeruginosa biofilms when used in combination with ciprofloxacin [ 92 ].…”

Section: Farnesolmentioning

confidence: 99%

Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms

Kovács

Majoros

2020

JoF

View full text Add to dashboard Cite

The number of effective therapeutic strategies against biofilms is limited; development of novel therapies is urgently needed to treat a variety of biofilm-associated infections. Quorum sensing is a special form of microbial cell-to-cell communication that is responsible for the release of numerous extracellular molecules, whose concentration is proportional with cell density. Candida-secreted quorum-sensing molecules (i.e., farnesol and tyrosol) have a pivotal role in morphogenesis, biofilm formation, and virulence. Farnesol can mediate the hyphae-to-yeast transition, while tyrosol has the opposite effect of inducing transition from the yeast to hyphal form. A number of questions regarding Candida quorum sensing remain to be addressed; nevertheless, the literature shows that farnesol and tyrosol possess remarkable antifungal and anti-biofilm effect at supraphysiological concentration. Furthermore, previous in vitro and in vivo data suggest that they may have a potent adjuvant effect in combination with certain traditional antifungal agents. This review discusses the most promising farnesol- and tyrosol-based in vitro and in vivo results, which may be a foundation for future development of novel therapeutic strategies to combat Candida biofilms.

show abstract

Farnesol increases the susceptibility of Burkholderia pseudomallei biofilm to antimicrobials used to treat melioidosis

Cited by 38 publications

References 28 publications

Butenolide, a Marine-Derived Broad-Spectrum Antibiofilm Agent Against Both Gram-Positive and Gram-Negative Pathogenic Bacteria

Butenolide, a Marine-Derived Broad-Spectrum Antibiofilm Agent Against Both Gram-Positive and Gram-Negative Pathogenic Bacteria

Terpene Derivatives as a Potential Agent against Antimicrobial Resistance (AMR) Pathogens

Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms

Contact Info

Product

Resources

About