Fas Gene Polymorphisms in Systemic Lupus Erythematosus and Serum Levels of Some Apoptosis-Related Molecules

Araste, Julia Maryam; Sarvestani, Eskandar Kamali; Aflaki, Elham; Amirghofran, Zahra

doi:10.3109/08820130903401736

Cited by 21 publications

(21 citation statements)

References 24 publications

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“…In general, apoptosis induction occurs via 2 classic pathways, extrinsic, and intrinsic. The extrinsic pathway is initiated by the ligation of death receptors (i.e., Fas) in the cell membrane, which results in the conversion of procaspase-8 to its activated form, after which procaspase-3 is activated either directly or by cleavage of Bid (12). In the intrinsic pathway, the 2 main molecules involved in the regulation of apoptosis are Bax that have a pro-apoptotic effect and B-cell lymphoma-2 (Bcl-2), with anti-apoptotic activity (13).…”

Section: Introductionmentioning

confidence: 99%

Apoptosis-inducing Effect of the Hexane Extracts from Three Native Iranian Euphorbia Plants

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Apoptosis-inducing Effect of the Hexane Extracts from Three Native Iranian Euphorbia Plants

et al. 2017

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“…The FAS -670A allele was associated with susceptibility to systemic lupus erythematosus (SLE) in a Japanese population (Kanemitsu et al, 2002). However, contradictory results between populations have been found in several autoimmune diseases (Kanemitsu et al, 2002;Niino et al, 2002;van Veen et al, 2002;Hiraide et al, 2005;Agarwal et al, 2007;Arasteh et al, 2010). A study in Caucasians found no association of the polymorphism with pSS susceptibility; however, the authors did not assess the possible influence of the FAS -670A>G polymorphism on sFas levels (Mullighan et al, 2004).…”

Section: Introductionmentioning

confidence: 78%

“…However, another group of studies in different populations found no such association (Niino et al, 2002;Arasteh et al, 2010). The difference in these association studies may be due to differences in genotype distributions between populations.…”

Section: Discussionmentioning

confidence: 95%

“…High levels of sFas have been reported in autoimmune diseases such as SLE, rheumatoid arthritis, and systemic sclerosis (Ates et al, 2004;Hao et al, 2006;Arasteh et al, 2010). The role of sFas has not been clarified, but it may inhibit Fas-mediated apoptosis by competing with the receptor for FasL binding (Cheng et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

“…High levels of sFas have been previously reported in the serum of patients with autoimmune diseases (Ates et al, 2004;Hao et al, 2006;Arasteh et al, 2010). The mechanisms underlying the increase in sFas remain unknown.…”

Section: Introductionmentioning

confidence: 99%

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FAS -670A>G promoter polymorphism is associated with soluble Fas levels in primary Sjögren’s syndrome

et al. 2014

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ABSTRACT. Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease characterized by lymphocytic infiltration of exocrine glands. Soluble Fas receptor (sFas) has been suggested as a Fas-mediated apoptosis blocker that could impair clonal deletion in infiltrated autoreactive cells. The FAS -670A>G promoter polymorphism has been studied in pSS. However, a relationship between FAS -670A>G promoter polymorphism and sFas levels in pSS had not been found. We examined this relationship in 77 Mexican pSS patients and 84 healthy subjects were included. Genotypes were identified by PCR-RFLP, and Fas soluble levels were quantified by ELISA. No significant differences between allele and genotype frequencies were found between these two groups. The sFas levels in the serum of pSS patients were significantly higher than in controls (9961 vs 8840 pg/mL, respectively). In addition, AA genotype carriers had significantly higher levels of sFas than GG carriers (pSS: 10,763 and 9422 pg/mL; controls: 9712 and 8305 pg/mL, respectively). An additive model analysis between genotypes (AG+GG vs AA) in both groups, demonstrated a significant association between carriers of the A allele and high sFas levels. In conclusion, carrying the double dose of A allele of FAS -670A>G polymorphism is associated with high levels of sFas in pSS, but it is not a susceptibility marker for pSS.

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Associations between the FAS −670 A/G and −1,377 G/A polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis

et al. 2012

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The aim of this study was to explore whether FAS -670 A/G and -1,377 G/A polymorphisms confer susceptibility to autoimmune rheumatic diseases. A meta-analysis was conducted on the associations between the FAS -670 A/G and -1,377 G/A polymorphisms and autoimmune rheumatic diseases using allele contrast, a recessive model, a dominant model, and an additive model. Thirteen articles with 21 comparison studies (16 on FAS -670 A/G and 5 on -1,377 G/A polymorphisms) including systemic lupus erythematosus (SLE), four systemic sclerosis, four Sjogren's syndrome, three rheumatoid arthritis (RA), one juvenile idiopathic arthritis, and one spondyloarthropathy were available for the meta-analysis. Meta-analysis revealed an association between rheumatic diseases and the FAS -670 A/G polymorphism in the dominant model (odds ratio [OR] = 0.761, 95 % confidence interval [CI] = 0.621-0.932, p = 0.008]. Stratification by ethnicity indicated an association between the FAS -670 G allele carrier and rheumatic diseases in Asian (OR = 0.569, 95 % CI = 0.409-0.791, p = 0.001). Furthermore, stratification by disease indicated an association between the FAS -670 G allele carrier and SLE and RA (OR = 0.578, 95 % CI = 0.358-0.934, p = 0.025; OR = 0.609, 95 % CI = 0.398-0.934, p = 0.023, respectively). The FAS -670 G allele was negatively associated with SLE susceptibility. Meta-analysis of the FAS -1,377 G/A polymorphism stratified by disease showed an association between the FAS -1,377 A allele and SLE (OR = 0.783, 95 % CI = 0.613-0.997, p = 0.047). Meta-analyses using the dominant model also showed a significant association in SLE (OR = 0.712, 95 % CI = 0.528-0.961, p = 0.027). This meta-analysis demonstrates that the FAS -670 A/G polymorphism confers susceptibility to rheumatic diseases in Asians and SLE and RA, and the FAS -1,377 G/A polymorphism is associated with SLE susceptibility.

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Fas Gene Polymorphisms in Systemic Lupus Erythematosus and Serum Levels of Some Apoptosis-Related Molecules

Cited by 21 publications

References 24 publications

Apoptosis-inducing Effect of the Hexane Extracts from Three Native Iranian Euphorbia Plants

Apoptosis-inducing Effect of the Hexane Extracts from Three Native Iranian Euphorbia Plants

FAS -670A>G promoter polymorphism is associated with soluble Fas levels in primary Sjögren’s syndrome

Associations between the FAS −670 A/G and −1,377 G/A polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis

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