Fas Ligand (FasL, Apo-1L/CD95L) Expression and Clinical Outcome in Papillary Microcarcinoma and Papillary Thyroid Carcinomas with Diameter Smaller than 1.5 Centimeters

Bayraktaroğlu, Taner; Boztepe, Hacer; Kapran, Yersu; Tanakol, Refik; Alagöl, Faruk

doi:10.1055/s-0029-1241205

Cited by 2 publications

(1 citation statement)

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“…The protein encoded by the Fas gene is a member of the TNF-receptor superfamily. This receptor contains a death domain, has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system (37). The present study showed that FasL expression (positivity, staining and intensity) was high and increased in papillary microcarcinoma of the thyroid tissue.…”

Section: Discussionsupporting

confidence: 50%

Key genes and pathways in thyroid cancer based on gene set enrichment analysis

Zhou

et al. 2013

Oncology Reports

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The incidence of thyroid cancer and its associated morbidity has shown the most rapid increase among all cancers since 1982, but the mechanisms involved in thyroid cancer, particularly significant key genes induced in thyroid cancer, remain undefined. In many studies, gene probes have been used to search for key genes involved in causing and facilitating thyroid cancer. As a result, many possible virulence genes and pathways have been identified. However, these studies lack a case contrast for selecting the most possible virulence genes and pathways, as well as conclusive results with which to clarify the mechanisms of cancer development. In the present study, we used gene set enrichment and meta-analysis to select key genes and pathways. Based on gene set enrichment, we identified 5 downregulated and 4 upregulated mixed pathways in 6 tissue datasets. Based on the meta-analysis, there were 17 common pathways in the tissue datasets. One pathway, the p53 signaling pathway, which includes 13 genes, was identified by both the gene set enrichment analysis and meta-analysis. Genes are important elements that form key pathways. These pathways can induce the development of thyroid cancer later in life. The key pathways and genes identified in the present study can be used in the next stage of research, which will involve gene elimination and other methods of experimentation.

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Section: Discussionsupporting

confidence: 50%