Fas (TNFRSF6) Gene Polymorphism in Pregnant Women With Hemolysis, Elevated Liver Enzymes, and Low Platelets and in Their Neonates

Sziller, István; Hupuczi, Petronella; Normand, Neil; Halmos, Amrita; Papp, Zoltán

doi:10.1097/01.aog.0000195824.51919.81

Cited by 10 publications

(11 citation statements)

References 27 publications

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“…The mechanisms are very complicated. Gene variants in the Fas receptor, the VEGF gene, and the coagulation factor V Leiden mutation are associated with increased risk of the HELLP syndrome compared to healthy women [51, 69, 77]. Variants in the Bell polymorphism [93] and the TLR-4 increased the risk of HELLP significantly more than the risk of preeclampsia [52].…”

Section: Discussion and Future Directionsmentioning

confidence: 99%

“…Sziller et al reported that a single adenine (A) to guanine (G) polymorphism at position −670 in the Fas receptor ( TNFRSF6) results in decreased Fas synthesis. A study by Sziller et al comprised women with a HELLP syndrome ( n = 84) and normotensive women ( n = 83) [51]. Cells from the buccal mucosa were obtained by rotating cotton swab within 1 hour after delivery.…”

Section: Polymorphism Of the Fas Receptormentioning

confidence: 99%

“…Cells from the buccal mucosa were obtained by rotating cotton swab within 1 hour after delivery. Genotype and allele frequencies were determined by direct counting and then dividing by number of chromosomes to obtain allele frequency and by the number of women to obtain genotype frequencies [51]. It was found that homozygous carriers with the −670 AG or GG genotype were more likely to develop the HELLP syndrome than those homozygous for the wild type of the Fas receptor (TNFRSF6−670A/A) (OR 2.7) (Table 2) [51].…”

Section: Polymorphism Of the Fas Receptormentioning

confidence: 99%

“…Genotype and allele frequencies were determined by direct counting and then dividing by number of chromosomes to obtain allele frequency and by the number of women to obtain genotype frequencies [51]. It was found that homozygous carriers with the −670 AG or GG genotype were more likely to develop the HELLP syndrome than those homozygous for the wild type of the Fas receptor (TNFRSF6−670A/A) (OR 2.7) (Table 2) [51]. The TNFRSF6−670 polymorphism is linked to decreased apoptotic potential of maternal T cells due to polymorphism in the Fas receptor at −670 which is thought to contribute to a prolonged capacity of maternal lymphocytes to recognize and destroy EVTs during invasion of the decidua and the spiral arteries which may lead to development of preeclampsia or HELLP syndrome [51].…”

Section: Polymorphism Of the Fas Receptormentioning

confidence: 99%

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Genetic Aspects of Preeclampsia and the HELLP Syndrome

Haram

Mortensen

Nagy

2014

Journal of Pregnancy

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Both preeclampsia and the HELLP syndrome have their origin in the placenta. The aim of this study is to review genetic factors involved in development of preeclampsia and the HELLP syndrome using literature search in PubMed. A familial cohort links chromosomes 2q, 5q, and 13q to preeclampsia. The chromosome 12q is coupled with the HELLP syndrome. The STOX1 gene, the ERAP1 and 2 genes, the syncytin envelope gene, and the −670 Fas receptor polymorphisms are involved in the development of preeclampsia. The ACVR2A gene on chromosome 2q22 is also implicated. The toll-like receptor-4 (TLR-4) and factor V Leiden mutation participate both in development of preeclampsia and the HELLP syndrome. Carriers of the TT and the CC genotype of the MTHFR C677T polymorphism seem to have an increased risk of the HELLP syndrome. The placental levels of VEGF mRNA are reduced both in women with preeclampsia and in women with the HELLP syndrome. The BclI polymorphism is engaged in development of the HELLP syndrome but not in development of severe preeclampsia. The ACE I/D polymorphism affects uteroplacental and umbilical artery blood flows in women with preeclampsia. In women with preeclampsia and the HELLP syndrome several genes in the placenta are deregulated. Preeclampsia and the HELLP syndrome are multiplex genetic diseases.

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Section: Discussion and Future Directionsmentioning

confidence: 99%

Section: Polymorphism Of the Fas Receptormentioning

confidence: 99%

Section: Polymorphism Of the Fas Receptormentioning

confidence: 99%

Section: Polymorphism Of the Fas Receptormentioning

confidence: 99%

See 2 more Smart Citations

Genetic Aspects of Preeclampsia and the HELLP Syndrome

Haram

Mortensen

Nagy

2014

Journal of Pregnancy

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“…A variety of other perinatal outcomes, such as small for gestational age or intrauterine growth restriction (Svensson, Pawitan, Cnattingius, Reilly, & Lichtenstein, 2006), pre‐eclampsia (Sziller et al, 2005), and HELLP syndrome (hemolytic anemia, elevated liver function tests, and low platelets; Sziller et al, 2006) are beginning to be studied as to their genetic basis, thus the trend toward a genomic approach is growing. Research is also showing the relationships among genomic, proteomic, and metabalomic predictors and environmental interactions that may place some women at greater risk of adverse pregnancy outcomes than others.…”

Section: Introductionmentioning

confidence: 99%