Fascicular topography of the median nerve: A computer based study to identify branching patterns

Watchmaker, Greg P.; Gumucio, Cesar A.; Crandall, R. Evan; Vannier, Michael A.; Weeks, Paul M.

doi:10.1016/s0363-5023(10)80013-9

Cited by 61 publications

(31 citation statements)

References 4 publications

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“…The subject could identify sensation at multiple sites independently. There is mounting evidence that peripheral nerves are somatotopically organized (24)(25)(26), and hence, multichannel cuff electrodes are able to produce somatotopically selective results similar to those reported in acute trials with intrafascicular electrodes (5,12,16). The peripheral interface in this trial produced punctate sensations in the hand with 19 of 20 channels (95%) or 9 of 16 channels (56%) from a proximal implant location.…”

Section: Va Author Manuscriptsupporting

confidence: 75%

A neural interface provides long-term stable natural touch perception

et al. 2014

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Touch perception on the fingers and hand is essential for fine motor control, contributes to our sense of self, allows for effective communication, and aids in our fundamental perception of the world. Despite increasingly sophisticated mechatronics, prosthetic devices still do not directly convey sensation back to their wearers. We show that implanted peripheral nerve interfaces in two human subjects with upper limb amputation provided stable, natural touch sensation in their hands for more than 1 year. Electrical stimulation using implanted peripheral nerve cuff electrodes that did not penetrate the nerve produced touch perceptions at many locations on the phantom hand with repeatable, stable responses in the two subjects for 16 and 24 months. Patterned stimulation intensity produced a sensation that the subjects described as natural and without "tingling," or paresthesia. Different patterns produced different types of sensory perception at the same location on the phantom hand. The two subjects reported tactile perceptions they described as natural tapping, constant pressure, light moving touch, and vibration. Changing average stimulation intensity controlled the size of the percept area; changing stimulation frequency controlled sensation strength. Artificial touch sensation improved the subjects' ability to control grasping strength of the prosthesis and enabled them to better manipulate delicate objects. Thus, electrical †

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Section: Va Author Manuscriptsupporting

confidence: 75%

A neural interface provides long-term stable natural touch perception

et al. 2014

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“…Other workers have confirmed these findings. 4,79 Degeneration experiments following section of lumbar and sacral spinal nerves in dogs showed that the fibers from an individual root take a relatively tightly packed course through the sciatic nerve; that is, they disperse into other fascicles less than Sunderland described in human nerve. 74 By contrast, degeneration experiments in the recurrent laryngeal nerve of the horse have shown that there is considerable mixing of nerve fibers and fascicles along the course of that nerve.…”

Section: Early Studiesmentioning

confidence: 99%

Peripheral nerve fascicles: Anatomy and clinical relevance

2003

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Within a peripheral nerve, the individual nerve fibers are grouped together in fascicles. Whether there is somatotopic organization within these fascicles has long been of interest, the subject of many investigations, and somewhat controversial. Evidence from diverse sources now points to important somatotopic clustering of nerve fibers within most of the length of the nerve. Information is lacking regarding proximal segments, particularly the plexus and spinal nerve root levels. As a result of this somatotopic arrangement, partial focal nerve lesions can produce restricted clinical deficits that defy the classic rules of localization. Examples of such restricted nerve lesions are provided in this review. Recognition of fascicle somatotopy is also important in the surgical approach to disorders of peripheral nerves.

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“…36,37 LIFEs were chosen to investigate the functionality of motor and sensory neurons in nerve stumps of human amputees because they can record from small clusters of neurons at a subfascicular level and can selectively activate subsets of nerve fibers within nerve fascicles by using injected charges on the order of 1 to 5 nC. 38 -40 LIFEs have been shown to be biocompatible in chronic animal studies and can be removed without requiring further surgery.…”

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confidence: 99%