Fascicular torsions of the anterior and posterior interosseous nerve in 4 cases: neuroimaging methods to improve diagnosis

Kollmer, Jennifer; Preisser, P; Bendszus, Martin; Kele, Henrich

doi:10.3171/2019.3.jns183302

Cited by 10 publications

(4 citation statements)

References 13 publications

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“…MR neurography (MRN) can overcome some of the aforementioned diagnostic limitations by directly visualizing peripheral nerve lesions 11–21 . The quantitative MRN parameters, proton spin density ( ρ ) and apparent T2 relaxation time ( T2 app ), have previously proven their feasibility to detect subclinical and early nerve lesions as well as to differentiate between neuropathic patients and controls or even between different disease severities in several neuropathies 14–18 .…”

Section: Introductionmentioning

confidence: 99%

Magnetization transfer ratio quantifies polyneuropathy in hereditary transthyretin amyloidosis

Kollmer

Hegenbart

Kimmich

et al. 2020

Ann Clin Transl Neurol

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Objective: To quantify peripheral nerve lesions in symptomatic and asymptomatic hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PNP) by analyzing the magnetization transfer ratio (MTR) of the sciatic nerve, and to test its potential as a novel biomarker for macromolecular changes. Methods: Twenty-five patients with symptomatic ATTRv-PNP, 30 asymptomatic carriers of the mutant transthyretin gene (mutTTR), and 20 age-/sexmatched healthy controls prospectively underwent magnetization transfer contrast imaging at 3 Tesla. Two axial three-dimensional gradient echo sequences with and without an off-resonance saturation rapid frequency pulse were conducted at the right distal thigh. Sciatic nerve regions of interest were manually drawn on 10 consecutive axial slices in the images without off-resonance saturation, and then transferred to the corresponding slices that were generated by the sequence with the off-resonance saturation pulse. Subsequently, the MTR and cross-sectional area (CSA) of the sciatic nerve were evaluated. Detailed neurologic and electrophysiologic examinations were conducted in all ATTRv-PNP patients and mutTTR-carriers. Results: Sciatic nerve MTR and CSA reliably differentiated between ATTRv-PNP, mutTTR-carriers, and controls. MTR was lower in ATTRv-PNP (26.4 AE 0.7; P < 0.0001) and in mutTTR-carriers (32.6 AE 0.8; P = 0.0005) versus controls (39.4 AE 2.1), and was also lower in ATTRv-PNP versus mutTTR-carriers (P = 0.0009). MTR correlated negatively with the NIS-LL and positively with CMAPs and SNAPs. CSA was higher in ATTRv-PNP (34.3 AE 1.7 mm 3 ) versus mutTTR-carriers (26.0 AE 1.1 mm 3 ; P = 0.0005) and versus controls (20.4 AE 1.2 mm 3 ; P < 0.0001). CSA was also higher in mutTTR-carriers versus controls. Interpretation: MTR is a novel imaging marker that can quantify macromolecular changes in ATTRv-PNP and differentiate between symptomatic ATTRv-PNP and asymptomatic mutTTRcarriers and correlates with electrophysiology.

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Section: Introductionmentioning

confidence: 99%

Magnetization transfer ratio quantifies polyneuropathy in hereditary transthyretin amyloidosis

Kollmer

Hegenbart

Kimmich

et al. 2020

Ann Clin Transl Neurol

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“…A study using medical images [18] reported that the PIN syndrome is often caused by the radial nerve trunk at the upper arm level rather than the supinator. Furthermore, a study highlighted the importance of neuroimaging methods for better diagnosis of fascicular torsion of the PIN [19]. The results of this study, along with those of the previous studies, provide the anatomic data needed for accurate diagnosis.…”

Section: Discussionmentioning

confidence: 55%

Relationship between the Branching Patterns of the Radial Nerve and Supinator Muscle

Jeon

Kim

Kwon

et al. 2021

BioMed Research International

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The posterior interosseous nerve (PIN) innervates the posterior compartment muscle of the forearm and is a continuation of the deep branch of the radial nerve. The anatomic descriptions of PIN vary among different authors. This study investigated the distribution patterns of PIN and its relationships to the supinator muscle. This study investigated which nerves innervate the posterior compartment muscles of the forearm, the radial nerve, and the PIN, using 28 nonembalmed limbs. Also, the points where the muscle attaches to the bone were investigated. The measured variables in this study were measured from the most prominent point of the lateral epicondyle of the humerus (LEH) to the most distal point of the radius styloid process. For each specimen, the distance between the above two points was assumed to be 100%. The measurement variables were the attachment area of the supinator and branching points from the radial nerve. The attachment points of the supinator to the radius and ulna were 47.9 % ± 3.6 % and 31.5 % ± 5.2 % , respectively, from the LEH. In 67.9% of the specimens, the brachioradialis and extensor carpi radialis longus (ECRL) were innervated by the radial nerve before superficial nerve branching, and the extensor carpi radialis brevis (ECRB) innervated the deep branch of the radial nerve. In 21.4% of the limbs, the nerve innervating the ECRB branched at the same point as the superficial branch of the radial nerve, whereas it branched from the radial nerve in 7.1% of the limbs. In 3.6% of the limbs, the deep branch of the radial nerve branched to innervate the ECRL. PIN was identified as a large branch without divisions in 10.7% and as a deep branch innervating the extensor digitorum in 14.3% of the limbs. The anatomic findings of this study would aid in the diagnosis of PIN syndromes.

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“…We actually found b = 0 map of rsDTI was similar to FSE T2WI image, which was valuable in assessing peripheral nerve diseases. [24][25][26] However, we found FSE T2WI, as well as b = 0 map, failed to well depict sciatic nerve when nerve and background tissue had similar signal intensity (SI). In contrast, sciatic nerve and background generally had substantially different signal in diffusion weighted map.…”

Section: Discussionmentioning

confidence: 80%

Readout-segmented diffusion tensor imaging for assessing sciatic nerve invasion by soft tissue tumor

Wan¹,

Wang²,

Chu³

et al. 2020

Preprint

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There are few publications regarding feasibility of readout-segmented diffusion tensor imaging (rsDTI) in assessing nerve invasion by soft tissue tumor. 64 patients with soft tissue mass in upper leg suspected of sciatic nerve invasion underwent rsDTI. Nerve invasion was confirmed in 28 cases by operation or electromyogram. The sciatic nerve was better depicted with diffusion weighted map versus b = 0 map of rsDTI. Inter-reader agreement in using rsDTI to rate nerve invasion was excellent. Sensitivity and specificity of rsDTI in identifying nerve invasion were 93% (26/28) and 92% (33/36) respectively. Apparent diffusion coefficient (ADC) was significantly higher in invaded nerves versus normal nerves (1.45 ± 0.67 × 10− 3mm2/s vs. 1.39 ± 0.46 × 10− 3mm2/s, P༜0.05). DTI derived FA was significantly lower in invaded nerves versus normal nerves (0.22 ± 0.11 vs. 0.37 ± 0.13, P༜0.05). Readout-segmented DTI was feasible in assessing sciatic nerve invasion by soft tissue tumor in selected patients.

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Fascicular torsions of the anterior and posterior interosseous nerve in 4 cases: neuroimaging methods to improve diagnosis

Cited by 10 publications

References 13 publications

Magnetization transfer ratio quantifies polyneuropathy in hereditary transthyretin amyloidosis

Magnetization transfer ratio quantifies polyneuropathy in hereditary transthyretin amyloidosis

Relationship between the Branching Patterns of the Radial Nerve and Supinator Muscle

Readout-segmented diffusion tensor imaging for assessing sciatic nerve invasion by soft tissue tumor

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