Fascin-1: Updated biological functions and therapeutic implications in cancer biology

Li, Chien‐Hsiu; Chan, Ming‐Hsien; Liang, Shu‐Mei; Chang, Yu‐Chan; Hsiao, Michael

doi:10.1016/j.bbadva.2022.100052

Cited by 4 publications

(2 citation statements)

References 218 publications

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“…Fascin-1 ( FSCN1 ) is a 55-kDa actin-bundling protein coded by a gene located on chromosome 7p22.1 with about 13.84 kb in length and includes five exons. Human FSCN1 is thought to be involved in the assembly of actin filament bundles found in lamellipodia, filopodia, microspikes, and stress fibers [ 13 , 14 ]. FSCN1 is abundantly expressed in many types of normal cells, including neurons, endothelial cells, glial cells, mesenchymal, and antigen-presenting dendritic cells, and is low or absent in normal epithelial cells [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

The association of FSCN1 (rs852479, rs1640233) and HOTAIR (rs920778) polymorphisms with the risk of breast cancer in Egyptian women

Galal,

Abdelhakam,

Ahmed

et al. 2024

Mol Biol Rep

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Background Breast cancer (BC) is one of the most prevalent cancers that contribute to mortality among women worldwide. Despite contradictory findings, considerable evidence suggests that single nucleotide polymorphisms (SNPs) in the FSCN1 and HOTAIR genes may have a causative impact on the development of BC. This case–control study was conducted to evaluate the association of genotype frequency in FSCN1 rs852479, rs1640233, and HOTAIR rs920778 with susceptibility and prognosis of BC, as well as the impact of clinical stages and hormonal features. Methods and results FSCN1 (rs852479, rs1640233) and HOTAIR (rs920778) were genotyped using TaqMan real-time PCR assay in 200 BC patients and 200 cancer-free controls, all representing Egyptian women. Genotypic analyses in association with clinicopathological factors and disease risk were assessed. As a result, a significant association with BC risk was observed for CC genotype frequency of FSCN1 rs852479 A > C (OR = 0.395, 95% CI 0.204–0.76, p-value = 0.005). However, no significant correlation was detected between the FSCN1 rs1640233 C > T and HOTAIR rs920778 C > T polymorphic variants and susceptibility to BC. Interestingly, CC genotype of FSCN1 rs1640233 was more likely to progress tumor size and lymph node invasion in BC cases (p-value = 0.04 and 0.02, respectively). Moreover, it was revealed that there was a non-significant correlation between the haplotype distributions of FSCN1 rs852479 and rs1640233 and the probability of BC. Conclusions Based on the sample size and genetic characteristics of the subjects involved in the present study, our findings indicated that FSCN1 rs852479 may contribute to BC susceptibility in a sample of the Egyptian population.

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Section: Introductionmentioning

confidence: 99%

The association of FSCN1 (rs852479, rs1640233) and HOTAIR (rs920778) polymorphisms with the risk of breast cancer in Egyptian women

Galal,

Abdelhakam,

Ahmed

et al. 2024

Mol Biol Rep

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“…Fascin actin-bundling protein 1 (FSCN1), a globular filamentous actin-binding protein, is abnormally overexpressed in multiple types of human cancer, such as laryngeal (5), bladder (6) and breast cancer (7), and elevated FScN1 levels have been shown to be a hallmark of an aggressive clinical progression and a poor prognosis (8)(9)(10). In vitro functional studies using cancer cell lines have revealed that FScN1 promotes cell growth, migration, invasion and metastasis in various types of cancer, such as oral cancer (11), osteosarcoma (12) and non-small cell lung cancer (8,13).…”

Section: Introductionmentioning

confidence: 99%

Identification of novel molecules and pathways associated with fascin actin‑bundling protein 1 in laryngeal squamous cell carcinoma through comprehensive transcriptome analysis

Liu,

Hao,

Wang

et al. 2024

Int J Mol Med

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Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor with a poor prognosis. Fascin actin-bundling protein 1 (FSCN1) has been reported to play a crucial role in the development and progression of LSCC; however, the underlying molecular mechanisms remain unknown. Herein, a whole transcriptome microarray analysis was performed to screen for differentially expressed genes (DEGs) in cells in which FSCN1 was knocked down. A total of 462 up and 601 downregulated mRNA transcripts were identified. Functional annotation analysis revealed that these DEGs were involved in multiple biological functions, such as transcriptional regulation, response to radiation, focal adhesion, extracellular matrix-receptor interaction, steroid biosynthesis and others. Through co-expression and protein-protein interaction analysis, FSCN1 was linked to novel functions, including defense response to virus and steroid biosynthesis. Furthermore, crosstalk analysis with FSCN1-interacting proteins revealed seven DEGs, identified as FSCN1-interacting partners, in LSCC cells, three of which were selected for further validation. Co-immunoprecipitation validation confirmed that FSCN1 interacted with prostaglandin reductase 1 and 24-dehydrocholesterol reductase (DHCR24). Of note, DHCR24 is a key enzyme involved in cholesterol biosynthesis, and its overexpression promotes the proliferation and migration of LSCC cells. These findings suggest that DHCR24 is a novel molecule associated with FSCN1 in LSCC, and that the FSCN1-DHCR24 interaction may promote LSCC progression by regulating cholesterol metabolism-related signaling pathways.

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The crucial role of fascin-1 in the pathogenesis, metastasis, and chemotherapeutic resistance of breast cancer

Abdullah,

Gamal El-Din,

El-Mahdy

et al. 2024

Pathology - Research and Practice

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Fascin-1: Updated biological functions and therapeutic implications in cancer biology

Cited by 4 publications

References 218 publications

The association of FSCN1 (rs852479, rs1640233) and HOTAIR (rs920778) polymorphisms with the risk of breast cancer in Egyptian women

The association of FSCN1 (rs852479, rs1640233) and HOTAIR (rs920778) polymorphisms with the risk of breast cancer in Egyptian women

Identification of novel molecules and pathways associated with fascin actin‑bundling protein 1 in laryngeal squamous cell carcinoma through comprehensive transcriptome analysis

The crucial role of fascin-1 in the pathogenesis, metastasis, and chemotherapeutic resistance of breast cancer

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