Fasciola Hepatica Extract Induces Cell Death of Mammalian Cells

Ferreira, Stéphanie; Fernandes, Rúben; Botelho, Mónica

doi:10.2174/1570180815666180531102555

Cited by 8 publications

(7 citation statements)

References 8 publications

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“…In contrast, infection or crude extract of Trichinella spiralis has been shown to have a protective role in carcinogenesis (Wang et al, 2009). Similarly, E. granulosus and Fasciola hepatica infection also has been associated with antitumor effect (Ferreira et al, 2018; Rostami Rad et al, 2018); however, the detailed mechanism is still illusive. Thus, the field is still wide open for further exploration before ascertaining their role in cancer.…”

Section: Cestodes and Nematodesmentioning

confidence: 99%

Neglected Agent Eminent Disease: Linking Human Helminthic Infection, Inflammation, and Malignancy

Arora

Kaur

Anjum

et al. 2019

Front. Cell. Infect. Microbiol.

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Helminthic parasitic infection is grossly prevalent across the globe and is considered a significant factor in human cancer occurrence induced by biological agents. Although only three helminths (Schistosoma haematobium, Clonorchis sinensis, and Opisthorchis viverrini) so far have been directly associated with carcinogenesis; there are evidence suggesting the involvement of other species too. Broadly, human helminthiasis can cause chronic inflammation, genetic instability, and host immune modulation by affecting inter- and intracellular communications, disruption of proliferation–anti-proliferation pathways, and stimulation of malignant stem cell progeny. These changes ultimately lead to tumor development through the secretion of soluble factors that interact with host cells. However, the detailed mechanisms by which helminths introduce and promote malignant transformation of host cells are still not clear. Here, we reviewed the current understanding of immune-pathogenesis of helminth parasites, which have been associated with carcinogenesis, and how these infections initiate carcinogenesis in the host.

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Section: Cestodes and Nematodesmentioning

confidence: 99%

Neglected Agent Eminent Disease: Linking Human Helminthic Infection, Inflammation, and Malignancy

Arora

Kaur

Anjum

et al. 2019

Front. Cell. Infect. Microbiol.

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“…hepatica extracts could have a potential as a preventive or even curative anti-cancer substance [9,10].…”

Section: The "Cancer Hygiene Hypothesis" Explainedmentioning

confidence: 99%

The Cancer Hygiene Hypothesis: From Theory to Therapeutic Helminths

Fernandes

Alves

Botelho

2019

CCTR

Self Cite

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Background:: The “Hygiene Hypothesis” was postulated by David Strachan in 1989 to explain for the rapid 20th century increase in allergic diseases such as asthma. In this hypothesis, children from developed countries living in ultra-hygienic environments and avoiding exposure to viruses, bacteria, and parasites, especially helminthes, have an increased risk of atopic disorders. Materials & Methods:: Research and online content related to cancer hygiene hypothesis is highlighted and to illustrate key themes. Guidelines for meaningful participation in DOC activities for people with diabetes, families, health care providers, and industry are provided. Results:: The lack of worms leads to failure of stimulation of mucosal Th2 responses. These infections exert their effect through critically altering T-helper (Th)1/Th2 regulation, and it is postulated that, thus, they protect against atopy and asthma, through the induction of Th1 regulatory response. It is now also recognized that this “hygiene hypothesis” concept applies to a wider range of chronic inflammatory diseases than atopy and asthma, such as diabetes, multiple sclerosis and cancer. Conclusion:: Here we discuss the major implications of these findings for the association between microorganisms and cancer, and also between some immune pathologies, like autoimmune diseases, and cancer.

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“…In order to develop an effective vaccine strategy, it is important to understand the key immunological features that the parasite triggers in the mammalian host. It has been shown that stimulation with liver fluke-derived extracts, such as excretory/secretory (ES) products and tegument, induce unbalanced Th1/Th2 responses (11–13), alternative activation of macrophages (14) and cell death (15). In addition, glycoconjugates derived from liver fluke extracts induce activation of peritoneal eosinophils (16) and apoptosis of macrophages (17).…”

Section: Introductionmentioning

confidence: 99%

Fasciola hepatica Infection in Cattle: Analyzing Responses of Peripheral Blood Mononuclear Cells (PBMC) Using a Transcriptomics Approach

et al. 2019

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The parasitic helminth Fasciola hepatica (liver fluke) causes economic loss to the livestock industry globally and also causes zoonotic disease. New control strategies such as vaccines are urgently needed, due to the rise of drug resistance in parasite populations. Vaccine development requires a comprehensive understanding of the immunological events during infection. Previous in vivo studies by our group have investigated global differentially expressed genes (DEGs) in ovine peripheral blood mononuclear cells (PBMC) in response to both acute and chronic F. hepatica infection. This work demonstrated that pathways involved in the pathogenesis of ovine fasciolosis included fibrosis, inhibition of macrophage nitric oxide production, and antibody isotype switching, among others. Transcriptomic changes in PBMC populations following F. hepatica infection in cattle, in which the disease phenotype is quite different, have not yet been examined. Using RNA sequencing we investigated gene expression changes in PBMC isolated from 9 non-infected and 11 F. hepatica-experimentally-infected calves immediately before infection, at 1 and at 14 weeks post-infection. Longitudinal time-course comparisons between groups revealed 21 and 1,624 DEGs driven exclusively by F. hepatica infection in cattle at acute and chronic stages, respectively. These results show that fewer DEGs at the acute stage of infection can be identified in cattle, as compared with sheep. In addition, the log 2 fold-changes of these DEGs were relatively low (−1 to 3) reflecting the different clinical presentation of F. hepatica infection in cattle. Gene pathways for hepatic fibrosis and hepatic cholestasis along with apoptosis of antigen-presenting cells were enriched at chronic stages. Our results reflect the major differences in the disease phenotype between cattle and sheep and may indicate pathways to target in vaccine development.

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Fasciola Hepatica Extract Induces Cell Death of Mammalian Cells

Cited by 8 publications

References 8 publications

Neglected Agent Eminent Disease: Linking Human Helminthic Infection, Inflammation, and Malignancy

Neglected Agent Eminent Disease: Linking Human Helminthic Infection, Inflammation, and Malignancy

The Cancer Hygiene Hypothesis: From Theory to Therapeutic Helminths

Fasciola hepatica Infection in Cattle: Analyzing Responses of Peripheral Blood Mononuclear Cells (PBMC) Using a Transcriptomics Approach

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