Fascioliasis in Pregnancy

Alatoom, Adnan; Sheffield, Jeanne S.; Gander, Rita M.; Shaw, Joanna; Cavuoti, Dominick

doi:10.1097/aog.0b013e31817c4ea7

Cited by 9 publications

(6 citation statements)

References 6 publications

(14 reference statements)

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“…In Mexico, although human infection appears also sporadically reported in recent years [54] – [59] , various aspects clearly suggest that the disease should be considered a national health concern: (i) human cases have been reported from several states other than Puebla, such as Hidalgo, Mexico, Veracruz, Chiapas, Oaxaca, San Luis-Potosi, Jalisco and Morelos [23] ; (ii) massively infected patients have been diagnosed [60] ; (iii) children have been found to be infected in surveys in Chiapas [61] and Mexico city [62] ; and (iv) several of the patients recently diagnosed in Canada and the United States were in fact immigrants from Mexico [63] – [67] . Prevalences and intensities found in the present study in Atlixco municipality are the highest so far recorded in the country and add thus concern about the possible level of human fascioliasis underestimation countrywide.…”

Section: Discussionmentioning

confidence: 99%

Fascioliasis and Intestinal Parasitoses Affecting Schoolchildren in Atlixco, Puebla State, Mexico: Epidemiology and Treatment with Nitazoxanide

et al. 2013

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BackgroundThe Atlixco municipality, Puebla State, at a mean altitude of 1840 m, was selected for a study of Fasciola hepatica infection in schoolchildren in Mexico. This area presents permanent water collections continuously receiving thaw water from Popocatepetl volcano (5426 m altitude) through the community supply channels, conforming an epidemiological scenario similar to those known in hyperendemic areas of Andean countries.Methodology and FindingsA total of 865 6–14 year-old schoolchildren were analyzed with FasciDIG coproantigen test and Lumbreras rapid sedimentation technique, and quantitatively assessed with Kato-Katz. Fascioliasis prevalences ranged 2.94–13.33% according to localities (mean 5.78%). Intensities were however low (24–384 epg). The association between fascioliasis and the habit of eating raw vegetables was identified, including watercress and radish with pronouncedly higher relative risk than lettuce, corncob, spinach, alfalfa juice, and broccoli. Many F. hepatica-infected children were coinfected by other parasites. Entamoeba histolytica/dispar, Giardia intestinalis, Blastocystis hominis, Hymenolepis nana and Ascaris lumbricoides infection resulted in risk factors for F. hepatica infection. Nitazoxanide efficacy against fascioliasis was 94.0% and 100% after first and second treatment courses, respectively. The few children, for whom a second treatment course was needed, were concomitantly infected by moderate ascariasis burdens. Its efficacy was also very high in the treatment of E. histolytica/E. dispar, G. intestinalis, B. hominis, H. nana, A. lumbricoides, Trichuris trichiura, and Enterobius vermicularis. A second treatment course was needed for all children affected by ancylostomatids.ConclusionsFascioliasis prevalences indicate this area to be mesoendemic, with isolated hyperendemic foci. This is the first time that a human fascioliasis endemic area is described in North America. Nitazoxanide appears as an appropriate alternative to triclabendazole, the present drug of choice for chronic fascioliasis. Its wide spectrum efficacy against intestinal protozooses and helminthiasis, usually coinfecting liver fluke infected subjects in human endemic areas, represents an important added value.

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Section: Discussionmentioning

confidence: 99%

Fascioliasis and Intestinal Parasitoses Affecting Schoolchildren in Atlixco, Puebla State, Mexico: Epidemiology and Treatment with Nitazoxanide

et al. 2013

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“…Fascioliasis is one of the most debilitating zoonotic diseases of domestic herbivores and human beings (Ashrafi et al 2006;WHO 2006;Lewin 2007;Alatoom et al 2008). Earlier, fascioliasis was limited to populations within well-defined watershed boundaries: however; recent environmental changes and modification in human behavior have increased the risk in other new populations (Savioli et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Effect of environmental factors on the fecundity, hatchability and survival of snail Lymnaea (Radix) acuminata (Lamarck): vector of fascioliasis

Jigyasu

Singh

2009

Journal of Water and Health

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“…On the clinical epidemiologial aspects showed that in pregnant women with fascioliasis, symptoms and signs are indistinguishable from hepatobiliary, digestive tract diseases or overlap with gestation terrains, and clinical signs of paediatric fascioliasis may mimic a wide spectrum of hepatobiliary disorders. Particularly, the combination of clinical pictures, laboratory finding parameters and imaging diagnostics, especially in FasELISA, hypereosinophilia and liver lesions by ultrasound and MRI or MDCT (in special cases) were very useful in definitive and confirmed diagnosis [3][4][5][6][7][8][9][10][11][12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Some Clinical Manifestations and Laboratory Findings of Human Gigantica Fascioliasis in Pregnant Women and Children in Central-Coastal Provinces, Vietnam, 2003-2017

2019

JPNB

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Introduction: Fascioliasis is a disease of the hepatobiliary system, caused by Fasciola spp that are increasing and threating of public health in the tropic areas, including of Central coastal of Vietnam. World Health Organisation estimates that at least 2.4 million people are infected in more than 70 countries worldwide, with several million at risk, and particularly, no continent is free from fascioliasis. This study carried out to evaluate several typical clinical and paracinical aspects in the pregnant women and children groups with fascioliasis. Methods: With the descriptive cross-sectional study design, and sample size in line with hospital based data. Results: the data post-analysis showed that total of 94 pregnant women and 212 child with gigantica fascioliasis were enrolled:- In the pregnant women group: the major clinical symptoms of epigastric and Chauffard Rivet triangle pain (95.74%), subshoulder muscle pain (97.87%), gastrointestinal disturbances as abdominal pain plus constipation (14.89%), loosed stool (22.34%), nausea and/or vomit (29.78%), mild fever (68%), allergic reaction with pruritis and urticaria (64.89%), mild anemia (4.26%), rare symptoms may be hepatomegaly (6.38%), chest pain, dyspnoea (43.62%), jaundice (2.13%); Laboratory parameters were positive ELISA test with Fasciola gigantica antigen (95.74%), hepatobiliary lesions by ultrasound (97.87%), majority in right liver (90.32%), eosinophilia is the predominant indicator (90.42%), In the children group: the clinical manifestations included of epigastric and Chauffard-Rivet area pain (94.34%), flatuence, nausea and intermittent vomiting (76.41%), digestive disoders (40.57%), allergy (30.66%), fatigue plus weight loss (12.74%); laboratory findings included of hepatobiliary lesions by US (100%), positive ELISA with Fasciola gigantica antigen (96.70%), eosinophil of 93.39% and 1.90% positive copro-examination with Fasciolae eggs. Conclusions: In pregnant women, symptoms are indistinguishable from hepatobiliary, digestive tract diseases or overlap with gestation terrains, and clinical signs of paediatric fascioliasis may mimic a wide spectrum of hepatobiliary disorders laboratory parameters and imaging diagnostics, especially in FasELISA, hypereosinophilia and liver lesions by ultrasound were very useful in positive diagnosis.

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Fascioliasis in Pregnancy

Abstract: Fascioliasis often mimics another common problem in pregnancy, cholelithiasis; clinicians need to be aware of this disease in high-risk populations.

Cited by 9 publications

References 6 publications

Fascioliasis and Intestinal Parasitoses Affecting Schoolchildren in Atlixco, Puebla State, Mexico: Epidemiology and Treatment with Nitazoxanide

Fascioliasis and Intestinal Parasitoses Affecting Schoolchildren in Atlixco, Puebla State, Mexico: Epidemiology and Treatment with Nitazoxanide

Effect of environmental factors on the fecundity, hatchability and survival of snail Lymnaea (Radix) acuminata (Lamarck): vector of fascioliasis

Some Clinical Manifestations and Laboratory Findings of Human Gigantica Fascioliasis in Pregnant Women and Children in Central-Coastal Provinces, Vietnam, 2003-2017

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