Fasciolosis—An Increasing Challenge in the Sheep Industry

Stuen, Snorre; Ersdal, Cecilie

doi:10.3390/ani12121491

Cited by 15 publications

(8 citation statements)

References 54 publications

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“…1 Given that transmission of F. hepatica in the United Kingdom is seasonal and that individual worm burdens typically accumulate year-on-year, careful and prompt administration of the most appropriate anthelminthic would be sensible here. Like fascioliasis and fasciolosis control amongst farmed livestock, 11,19 effective and regular anthelminthic treatment curtails juvenile and adult worm burdens, thereby averting any future morbidity that might otherwise arise without intervention(s). From direct experience here, Fasinex (triclabendazole) would be the future anthelmintic of choice, although additional posttreatment coprological monitoring is needed, being alert to reduced antiparasitic efficacy in United Kingdom livestock nearby.…”

Section: Discussionmentioning

confidence: 99%

On Liver Fluke (Fasciola Hepatica) in Captive Vicuñas (Vicugna Vicugna) at Knowsley Safari, Prescot, United Kingdom

Juhasz,

Chapman,

Martin

et al. 2023

Journal of Zoo and Wildlife Medicine

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Knowsley Safari (KS), Prescot, United Kingdom houses a variety of captive exotic ungulates. As part of their animal welfare plan, a prospective coprological survey was undertaken for liver fluke. In June 2021, 330 fecal samples, representative of 18 exotic ungulate species, were processed by sedimentation and filtration, with examination by coproscopy. Finding fascioliasis in all five vicu ña alone, with fecal egg counts ranging from one to eight eggs per gram, anthelminthic treatment was attempted twice, with three coprological reviews. While the first anthelminthic treatment (oxyclozanide) was equivocal, the second anthelminthic treatment (triclabendazole) was proven effective upon two later follow-ups. An initial malacological survey of 16 freshwater sites in KS, first found Galba truncatula at two sites in June 2021, then upon more extensive searching subsequently within the vicu ña's enclosure. It appears that F. hepatica was locally acquired, being the first report of fascioliasis within captive vicu ñas in the United Kingdom. To develop a better fluke-management plan, regular coprological and malacological surveillance is justified, perhaps with molecular xenomonitoring of snails, alongside prompt administration of appropriate flukicide as required.

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Section: Discussionmentioning

confidence: 99%

On Liver Fluke (Fasciola Hepatica) in Captive Vicuñas (Vicugna Vicugna) at Knowsley Safari, Prescot, United Kingdom

Juhasz,

Chapman,

Martin

et al. 2023

Journal of Zoo and Wildlife Medicine

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“…In this context, the permanent elimination of eggs becomes a priority to facilitate transmission throughout the year, as in the zones where our study was conducted. In contrast, in some Mexican regions, transmission of the trematode is seasonal (62), as in Plot for the comparison of F. hepatica specimens from Antioquia, Boyacá, Cauca, Cundinamarca, Nariño, Norte de Santander, and Santander (Colombia), with F. hepatica specimens from Altiplano Bolivia, Cajamarca (Peru), San Juan (Ecuador), Valencia (Spain), Corsica (France) and F. gigantica from Bobo Dioulasso (Burkina Faso). The samples are projected onto the first (PC1, 66.6%) and second (PC2, 21%) principal components.…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization of Fasciola hepatica in endemic regions of Colombia

García-Corredor¹,

Alvarado²,

Pulido-Medellín³

et al. 2023

Front. Vet. Sci.

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Fasciola hepatica is a zoonotic trematode that affects a wide range of hosts, including cattle, sheep, and goats. The economic impact of the parasite on the cattle industry is significant, with high losses reported worldwide. While its impact on human health was previously underestimated, recent years have seen a rise in fascioliasis cases, leading to increased interest among researchers globally. To characterize the genetic diversity and intraspecific variation of this parasite in South America, specifically in Colombia, we collected 105 adult parasites from cattle bile ducts in seven Colombian departments (Antioquia, Boyacá, Santander, Cauca, Cundinamarca, Nariño, Norte de Santander, and Santander) to assess the parasite’s phenotypic analyses, genetic diversity, and population structure. A computer image analysis system (CIAS) was applied based on standardized morphological measurements. Liver-fluke size was studied by principal component analysis (PCA). DNA sequences were obtained for nuclear markers such as the 28S, β-tubulin 3, ITS1, ITS2, and the mitochondrial marker Cytochrome Oxidase I (COI). Multiple statistical tests were performed, and the parasite’s population structure was analyzed. Maximum Likelihood (ML) phylogenetic reconstructions were carried out using the sequences obtained herein and sequences available in GenBank. Morphological results revealed that all the obtained individuals matched F. hepatica’s morphology. There was no evidence of high genetic diversity, and the absence of genetic structure at the country-level was notable, possibly caused by a demographic expansion of this trematode in Colombia or the low resolution of the molecular markers employed. Future studies are still needed to unveil the genetic population structure of F. hepatica across the country.

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“…Additionally, it may not be readily accessible for production in countries like Argentina. The latter is particularly relevant because fasciolosis in sheep is likely to escalate and spread in the coming years due to climate change, with temperature increases that favour the persistence of the parasite and its intermediate hosts [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Antibody detection against Kunitz-type protein in Fasciola hepatica experimentally infected sheep using enzyme-linked immunosorbent assay (ELISA)

Ahumada,

Godino,

Guasconi

et al. 2023

International Journal of Veterinary Science and Medicine

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Fasciolosis is a parasitic disease considered as emerging and neglected by the WHO. Sheep are highly susceptible to this disease, and affected flocks experience decreased productivity due to increased mortality, and the reduced quality of their products, such as wool and meat. To effectively control this disease, reliable and early diagnosis is essential for making decisions regarding antiparasitic application and/or the removal of affected animals. Currently, the diagnosis of F. hepatica in sheep relies on the detection of parasite eggs in faeces, a method that becomes reliable from week 10 post-infection. Consequently, there is a need for earlier diagnostic tools based on immune response. However, obtaining antigens for antibody detection has proven to be difficult and expensive. The aim of this study was to evaluate members of the Kunitz protein family of F. hepatica expressed in the form of a fusion protein in the serological diagnosis of F. hepatica in sheep. The performance of three recombinant F. hepatica Kunitz-type inhibitors (FhKT1.1, FhKT1.3, and FhKT4) was compared with a synthetic Kunitz-type peptide (sFhKT) in sera from sheep experimentally infected with F. hepatica , using an ELISA. Of these, FhKT1.1 showed the most promising diagnostic indicators, exhibiting high precision and low cross-reactivity, and thus potential for standardized production. The results of our study demonstrated that the application of FhKT1.1 is a valuable tool for early-stage diagnosis of F. hepatica in sheep. Such an early diagnosis can aid in implementing timely interventions and effectively managing the disease in sheep populations.

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Fasciolosis—An Increasing Challenge in the Sheep Industry

Cited by 15 publications

References 54 publications

On Liver Fluke (Fasciola Hepatica) in Captive Vicuñas (Vicugna Vicugna) at Knowsley Safari, Prescot, United Kingdom

On Liver Fluke (Fasciola Hepatica) in Captive Vicuñas (Vicugna Vicugna) at Knowsley Safari, Prescot, United Kingdom

Molecular characterization of Fasciola hepatica in endemic regions of Colombia

Antibody detection against Kunitz-type protein in Fasciola hepatica experimentally infected sheep using enzyme-linked immunosorbent assay (ELISA)

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