Fast and green extraction and separation of main bioactive flavonoids from Radix Scutellariae

Wei, Zuo‐Fu; Wang, Xiqing; Xiao, Pei; Wang, Wei; Zhao, Chunjian; Zu, Yuangang; Fu, Yujie

doi:10.1016/j.indcrop.2014.10.013

Cited by 180 publications

(91 citation statements)

References 22 publications

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“…Interestingly, NADES can form hydrogen bonds with solutes, which enables the development of different analytical applications . NADES have received growing attention for the extraction and separation of analytes from natural sources . The latter is attributed to their high solubilization and stabilization abilities of both non‐polar and polar compounds.…”

Section: Resultsmentioning

confidence: 99%

A Greener Approach to Prepare Natural Deep Eutectic Solvents

et al. 2018

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Natural deep eutectic solvents (NADES) is one of the hottest issues in the field of green chemistry. However, it is possible to make them greener? Herein we propose a new microwave (MW) assisted preparation demanding only seconds. The MW‐NADES were challenged with those obtained by the classical Heating & Stirring procedure in terms of green analytical metrics and physical parameters. Indeed, the following analytical applications were tested: a) extraction media for phenolics and alkaloids from plant, b) enhancers for electrochemical detection of phenolic compounds. Our results demonstrate outstanding environmental advantages as the dramatic decrease of synthesis time (the shortest time to date, 60 minutes to 20 seconds) and energy consumption (650 times lower). The analytical performance and physicochemical parameters were comparable with the traditional NADES.

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Section: Resultsmentioning

confidence: 99%

A Greener Approach to Prepare Natural Deep Eutectic Solvents

et al. 2018

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“…NADES therefore have good potential for the extraction of valuable secondary metabolites for use in the food and pharmaceutical industries. Recently, NADES have been applied for extraction of flavonoids (Wei et al 2015a;Radošević et al 2016;Bakirtzi et al 2016;Dai et al 2016), alkaloids, phenolic acids, anthraquinones, saponins (Duan et al 2016, phenolic compounds (Wei et al 2015b), xanthonoids (Mulia et al 2015), rutin (Huang et al 2017), flavonoid glycosides, and aglycones (Zhuang et al 2017) from plant materials. The mentioned publications describe the extraction of flavonoids other than those described in our research and the application of different NADES solvents for sample preparation.…”

Section: Introductionmentioning

confidence: 99%

Development of a Method Based on Natural Deep Eutectic Solvents for Extraction of Flavonoids from Food Samples

2017

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Natural deep eutectic solvents (NADES) are promising green solvents for the extraction of compounds from natural products. This is the first study to use a sample preparation method based on NADES for the extraction of flavonoids (rutin, hesperidin, neohesperidin, naringenin, naringin, quercetin, hesperetin, and chrysin) from fruits, vegetables, and spices. In total, 17 types of NADES based on choline chloride, acetylcholine chloride, choline tartrate, betaine, and carnitine with different compositions were tailored to test their extraction efficiency. Operational conditions such as water content in NADES and liquid/solid ratios were also studied. A response surface methodology was used for multivariate optimization of some extraction parameters. Efficient recovery of extracted flavonoids (higher than 70%) was achieved using a 30% water solution of acetylcholine chloride/lactic acid ratio (2:1) as an extraction solvent. Other conditions for SLE-NADES were as follows: liquid/solid ratio 3:1, extraction temperature 60°C, extraction time 30 min, and stirring speed 1400 rpm. Each extract was analyzed by UHPLC with UVand MS/ MS detection. The developed method was applied for analysis of flavonoids in fruits (cranberry, fruits of Lycium barbarum L., grape, plum, and orange peel), vegetables (onion and broccoli), and spices (mustard, rosemary, and black pepper).

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“…1) is is a natural flavone compound abundant in the rhizome of the perennial herb Scutellaria baicalensis , known as huangqin in Chinese traditional medicine [13]. By using ApoE -/- mice, our group previously demonstrated that baicalin attenuates atherosclerosis through lipids regulation and dendritic cells inhibition [14, 15].…”

Section: Introductionmentioning

confidence: 99%

Baicalin Attenuates Cardiac Dysfunction and Myocardial Remodeling in a Chronic Pressure-Overload Mice Model

Zhang

Liao

Zhu

et al. 2017

Cell Physiol Biochem

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Background/Aims: Baicalin has been shown to be effective for various animal models of cardiovascular diseases, such as pulmonary hypertension, atherosclerosis and myocardial ischaemic injury. However, whether baicalin plays a role in cardiac hypertrophy remains unknown. Here we investigated the protective effects of baicalin on cardiac hypertrophy induced by pressure overload and explored the potential mechanisms involved. Methods: C57BL/6J-mice were treated with baicalin or vehicle following transverse aortic constriction or Sham surgery for up to 8 weeks, and at different time points, cardiac function and heart size measurement and histological and biochemical examination were performed. Results: Mice under pressure overload exhibited cardiac dysfunction, high mortality, myocardial hypertrophy, increased apoptosis and fibrosis markers, and suppressed cardiac expression of PPARα and PPARβ/δ. However, oral administration of baicalin improved cardiac dysfunction, decreased mortality, and attenuated histological and biochemical changes described above. These protective effects of baicalin were associated with reduced heart and cardiomyocyte size, lower fetal genes expression, attenuated cardiac fibrosis, lower expression of profibrotic markers, and decreased apoptosis signals in heart tissue. Moreover, we found that baicalin induced PPARα and PPARβ/δ expression in vivo and in vitro. Subsequent experiments demonstrated that long-term baicalin treatment presented no obvious cardiac lipotoxicity. Conclusions: The present results demonstrated that baicalin attenuates pressure overload induced cardiac dysfunction and ventricular remodeling, which would be due to suppressed cardiac hypertrophy, fibrosis, apoptosis and metabolic abnormality.

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Fast and green extraction and separation of main bioactive flavonoids from Radix Scutellariae

Cited by 180 publications

References 22 publications

A Greener Approach to Prepare Natural Deep Eutectic Solvents

A Greener Approach to Prepare Natural Deep Eutectic Solvents

Development of a Method Based on Natural Deep Eutectic Solvents for Extraction of Flavonoids from Food Samples

Baicalin Attenuates Cardiac Dysfunction and Myocardial Remodeling in a Chronic Pressure-Overload Mice Model

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