Fast and slow myosins as markers of muscle injury

Guerrero, Mario; Guiu-Comadevall, M; Cadefau, Joan A.; Parra, Johanna; Balius, Ramón; Estruch, A.; Rodas, Gil; Bedini, José Luis; Cussó, Roser

doi:10.1136/bjsm.2007.037945

Cited by 35 publications

(39 citation statements)

References 44 publications

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“…The results of our study suggest that differences in muscle damage cannot be accounted for by differences only in muscle fiber composition, although it has been established that fast-twitch fibers are more vulnerable (Fridén and Lieber 2001;Guerrero et al 2008). If muscle damage depended only on muscle composition, then symptoms in LDR would be less pronounced than in S and VP, which was not the case in this study.…”

Section: Causes Of Depressed Neuromuscular Function After Eccentric Ementioning

confidence: 49%

The effect of sports specialization on musculus quadriceps function after exercise-induced muscle damage

Skurvydas

Brazaitis

Venckūnas

et al. 2011

Appl. Physiol. Nutr. Metab.

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The primary aim of the present study was to examine the effect of eccentric exercise-induced (100 submaximal eccentric contractions at an angular velocity of 60° s⁻¹, with 20-s rest intervals) muscle damage on peripheral and central fatigue of quadriceps muscle in well-trained long-distance runners, sprint runners, volleyball players, and untrained subjects. We found that (i) indirect symptoms of exercise-induced muscle damage (prolonged decrease in maximal voluntary contraction, isokinetic concentric torque, and electrically induced (20 Hz) torque) were most evident in untrained subjects, while there were no significant differences in changes of muscle soreness and plasma creatine kinase 48 h after eccentric exercise between athletes and untrained subjects; (ii) low-frequency fatigue was greater in untrained subjects and volleyball players than in sprint runners and long-distance runners; (iii) in all subjects, electrically induced (100 Hz) torque decreased significantly by about 20%, while central activation ratio decreased significantly by about 8% in untrained subjects and sprint runners, and by about 3%-5% in long-distance runners and volleyball players. Thus, trained subjects showed greater resistance to exercise-induced muscle damage for most markers, and long-distance runners had no advantage over sprint runners or volleyball players.

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Section: Causes Of Depressed Neuromuscular Function After Eccentric Ementioning

confidence: 49%

The effect of sports specialization on musculus quadriceps function after exercise-induced muscle damage

Skurvydas

Brazaitis

Venckūnas

et al. 2011

Appl. Physiol. Nutr. Metab.

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“…More research is needed to determine the real diagnostic and prognostic value of potential markers, such as ‘fast myosin heavy chains’ (fast MHC) [26], ‘skeletal-troponin I’ (sTnI) [55] and ‘alfa-actin’ [40]. …”

Section: Resultsmentioning

confidence: 99%

Diagnosis and prognosis of acute hamstring injuries in athletes

Kerkhoffs

Wieldraaijer

et al. 2012

Knee Surg Sports Traumatol Arthrosc

102

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PurposeIdentification of the most relevant diagnostic and prognostic factors of physical examination and imaging of hamstring injuries in (elite) athletes.MethodsA literature search was conducted in MEDLINE and EMBASE for articles between 1950 and April 2011. A survey was distributed among the members of the European Society of Sports Traumatology, Knee Surgery and Arthroscopy, which focused on physical examination, prognosis, imaging and laboratory tests of hamstring injuries in (elite) athletes.ResultsMedical history, inspection and palpation of the muscle bellies and imaging are most valuable at the initial assessment according to the literature. Experts considered medical history, posture and gait inspection, inspection and palpation of muscle bellies, range of motion tests, manual muscle testing, referred pain tests and imaging to be most important in the initial assessment of hamstring injuries. Magnetic resonance imaging (MRI) is preferred over ultrasonography and should take place within 3 days post-trauma. Important prognostic factors are injury grade, length of the muscle tear on MR images, MRI-negative injuries and trauma mechanism.ConclusionsPosture and gait inspection, inspection and palpation of muscle bellies, range of motion tests, manual muscle testing and referred pain tests within 2 days post-trauma were identified as the most relevant diagnostic factors.Level of evidenceLiterature review and expert opinion, Level V.

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“…A player is totally rehabilitated when the medical team considers that he is suitable to re-start soccer activity fully 2 3 13 14. We did not use any specific functional or metabolic test for the purpose of evaluating recovery as none of the current testing has been shown to be statistically valid as suggested by Cross and colleagues 9 15 16…”

Section: Methodsmentioning

confidence: 99%

Central aponeurosis tears of the rectus femoris: practical sonographic prognosis

Balius

Maestro²,

Pedret

et al. 2009

Br J Sports Med

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Objective: This study is a statistical analysis to establish whether a correlation exists between the level and degree of rectus femoris (RF) central tendon injury and the amount of time that an athlete is unable to participate subsequently, referred to as ''sports participation absence'' (SPA). Design: Causal-comparative study. Patients: 35 players from two high-level Spanish soccer teams with an injury to the central tendon of the RF based on clinical and ultrasound criteria. Main Outcome Measure: Ultrasound examination was performed with an 8-2 MHz linear multifrequency transducer. All studies included both longitudinal and transverse RF sections. Results: At the proximal level the SPA time is 45.1 days when the injury length is 4.0 cm. This value increases by 5.3 days with each 1 cm increase in the length of injury. In the case of distal level injury, SPA time is 32.9 days when the injury length is 3.9 cm. This value increases by 3.4 days with each 1 cm increase. In the total representative sample, SPA time when the injury length is 4.2 cm corresponds to 39.1 days. This value increases by 4.2 days per length unit. Conclusions: RF central tendon injury at the proximal level is associated with a greater SPA time than at the distal level. Patients with a grade II injury have an SPA time longer than those with a grade I injury whether the injury is located proximal or distal.The rectus femoris (RF) muscle is particularly vulnerable to injury because of the following characteristics: it spans two joints; the majority of its fibres are type II fast twitch; it performs eccentric-specific work during sporting activities.

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Fast and slow myosins as markers of muscle injury

Cited by 35 publications

References 44 publications

The effect of sports specialization on musculus quadriceps function after exercise-induced muscle damage

The effect of sports specialization on musculus quadriceps function after exercise-induced muscle damage

Diagnosis and prognosis of acute hamstring injuries in athletes

Central aponeurosis tears of the rectus femoris: practical sonographic prognosis

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