Fast and versatile fabrication of PMMA microchip electrophoretic devices by laser engraving

Abstract

This paper describes the effects of different modes and engraving parameters on the dimensions of microfluidic structures produced in PMMA using laser engraving. The engraving modes included raster and vector while the explored engraving parameters included power, speed, frequency, resolution, line-width and number of passes. Under the optimum conditions, the technique was applied to produce channels suitable for CE separations. Taking advantage of the possibility to cut-through the substrates, the laser was also used to define solution reservoirs (buffer, sample, and waste) and a PDMS-based decoupler. The final device was used to perform the analysis of a model mixture of phenolic compounds within 200 s with baseline resolution.

Development and characterization of carbon based electrodes from pyrolyzed paper for biosensing applications

“…The samples were then removed from the furnace and affixed to a Plexiglas substrate using double sided tape. In order to define a uniform electrode size, the electrodes were then patterned using a commercial CO 2 laser engraver (Mini24, Epilog Laser Systems; Golden, CO, USA),[42-44] defining electrodes like the one shown in Figure 1. To keep water from wicking up the stem of the electrode (and modifying the electrode area), paraffin paper was wrapped around the base of the stem (between the circular pad and the contact area) and melted in place using a hot air gun.…”

Rational selection of substrates to improve color intensity and uniformity on microfluidic paper-based analytical devices

“…Moreover, since the machine uses a CO 2 laser (wavelength of 10.6 μm) to cut the paper, the edge of the paper is ablated creating a hydrophobic boundary. 14 Although a detailed description of the capabilities of the instrument can be found elsewhere, 33 all μPADs used in the experiments herein described were cut using the vector mode, at 30% speed (of a maximum linear speed of 1.65 cm·s −1 ) and 30% power (of a maximum intensity of 30 W). In order to minimize the possibility of ignition 2 of the paper inside the engraver, the engraving head was constantly used to impinge a stream of N 2 (house line) on the engraving spot.…”

Wearable Technology for Chronic Wound Monitoring: Current Dressings, Advancements, and Future Prospects

“… f Xia and Whitesides ( 1998 ) and Qin et al ( 2010 ) . g Gabriel et al ( 2014 ) . h Xu et al ( 2014 ) .…”

“…Laser engraving is a form of non-contact fabrication employing a high-energy CO 2 laser beam to cut through a material. The beam can either be continuous or have pulses fired in rapid succession (Gabriel et al, 2014 ). For most models, the stage is stationary while the laser beam moves to cut the design, or the stage moves underneath the laser beam.…”